NFAC1.H12CORE.0.P.B motif - HOmo sapiens COmprehensive MOdel COllection

Motif	NFAC1.H12CORE.0.P.B
Gene (human)	NFATC1 (GeneCards)
Gene synonyms (human)	NFAT2, NFATC
Gene (mouse)	Nfatc1
Gene synonyms (mouse)	Nfat2, Nfatc
LOGO
LOGO (reverse complement)
Motif subtype	0
Quality	B

Motif length	16
Consensus	WGGAARvdnTKWvWMW
GC content	39.16%
Information content (bits; total / per base)	13.663 / 0.854
Data sources	ChIP-Seq
Aligned words	996

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Human	3 (16)	0.58	0.791	0.478	0.723	0.606	0.797	1.794	2.995	22.204	83.602
Mouse	3 (18)	0.86	0.93	0.828	0.89	0.867	0.934	4.144	4.59	354.418	512.699

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 6 experiments	median	0.817	0.761	0.739	0.69	0.671	0.638
Overall, 6 experiments	best	0.949	0.916	0.923	0.885	0.859	0.825
Methyl HT-SELEX, 2 experiments	median	0.889	0.839	0.848	0.8	0.78	0.744
Methyl HT-SELEX, 2 experiments	best	0.949	0.916	0.923	0.885	0.859	0.825
Non-Methyl HT-SELEX, 4 experiments	median	0.784	0.734	0.694	0.659	0.615	0.606
Non-Methyl HT-SELEX, 4 experiments	best	0.913	0.871	0.844	0.803	0.729	0.715

TF superclass	Immunoglobulin fold {6} (TFClass)
TF class	Rel homology region (RHR) factors {6.1} (TFClass)
TF family	NFAT-related {6.1.3} (TFClass)
TF subfamily	{6.1.3.0} (TFClass)
TFClass ID	TFClass: 6.1.3.0.1
HGNC	HGNC:7775
MGI	MGI:102469
EntrezGene (human)	GeneID:4772 (SSTAR profile)
EntrezGene (mouse)
UniProt ID (human)	NFAC1_HUMAN
UniProt ID (mouse)	NFAC1_MOUSE
UniProt AC (human)	O95644 (TFClass)
UniProt AC (mouse)	O88942 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	3 human, 3 mouse
HT-SELEX	4
Methyl-HT-SELEX	2

PCM	NFAC1.H12CORE.0.P.B.pcm
PWM	NFAC1.H12CORE.0.P.B.pwm
PFM	NFAC1.H12CORE.0.P.B.pfm
Alignment	NFAC1.H12CORE.0.P.B.words.tsv
Threshold to P-value map	NFAC1.H12CORE.0.P.B.thr
Motif in other formats
JASPAR format	NFAC1.H12CORE.0.P.B_jaspar_format.txt
MEME format	NFAC1.H12CORE.0.P.B_meme_format.meme
Transfac format	NFAC1.H12CORE.0.P.B_transfac_format.txt
Homer format	NFAC1.H12CORE.0.P.B_homer_format_0.001.txt NFAC1.H12CORE.0.P.B_homer_format_0.0005.txt NFAC1.H12CORE.0.P.B_homer_format_0.0001.txt

PCM

	A	C	G	T
01	190.0	48.0	69.0	689.0
02	12.0	1.0	980.0	3.0
03	6.0	2.0	988.0	0.0
04	941.0	18.0	35.0	2.0
05	944.0	3.0	35.0	14.0
06	791.0	62.0	81.0	62.0
07	531.0	173.0	204.0	88.0
08	411.0	68.0	111.0	406.0
09	345.0	227.0	255.0	169.0
10	78.0	52.0	56.0	810.0
11	67.0	74.0	670.0	185.0
12	732.0	56.0	92.0	116.0
13	147.0	319.0	443.0	87.0
14	127.0	112.0	77.0	680.0
15	174.0	618.0	111.0	93.0
16	672.0	94.0	107.0	123.0

PFM

	A	C	G	T
01	0.191	0.048	0.069	0.692
02	0.012	0.001	0.984	0.003
03	0.006	0.002	0.992	0.0
04	0.945	0.018	0.035	0.002
05	0.948	0.003	0.035	0.014
06	0.794	0.062	0.081	0.062
07	0.533	0.174	0.205	0.088
08	0.413	0.068	0.111	0.408
09	0.346	0.228	0.256	0.17
10	0.078	0.052	0.056	0.813
11	0.067	0.074	0.673	0.186
12	0.735	0.056	0.092	0.116
13	0.148	0.32	0.445	0.087
14	0.128	0.112	0.077	0.683
15	0.175	0.62	0.111	0.093
16	0.675	0.094	0.107	0.123

PWM

	A	C	G	T
01	-0.268	-1.618	-1.266	1.013
02	-2.905	-4.522	1.365	-3.971
03	-3.48	-4.209	1.373	-4.979
04	1.324	-2.542	-1.921	-4.209
05	1.328	-3.971	-1.921	-2.769
06	1.151	-1.37	-1.109	-1.37
07	0.754	-0.361	-0.198	-1.028
08	0.498	-1.28	-0.799	0.486
09	0.324	-0.092	0.024	-0.384
10	-1.146	-1.54	-1.469	1.175
11	-1.294	-1.197	0.985	-0.295
12	1.074	-1.469	-0.984	-0.756
13	-0.522	0.246	0.573	-1.039
14	-0.667	-0.791	-1.158	1.0
15	-0.355	0.905	-0.799	-0.973
16	0.988	-0.963	-0.836	-0.698

Standard thresholds

P-value	Threshold
0.001	3.69256
0.0005	4.74306
0.0001	6.90876