MotifNANOG.H12INVITRO.2.M.C
Gene (human)NANOG
(GeneCards)
Gene synonyms (human)
Gene (mouse)Nanog
Gene synonyms (mouse)Ecat4, Enk
LOGO
LOGO (reverse complement)
Motif subtype2
Quality
C
Motif length12
ConsensusnRTTAAKGdddd
GC content31.4%
Information content (bits; total / per base)10.811 / 0.901
Data sourcesMethyl-HT-SELEX
Aligned words6689

ChIP-Seq benchmarking Num. of experiments (peaksets) auROC, median auROC, best auPRC, median auPRC, best pseudo-auROC, median pseudo-auROC, best pseudo-log-auROC, median pseudo-log-auROC, best Centrality, median Centrality, best
Human 15 (95) 0.543 0.598 0.372 0.413 0.576 0.639 1.315 1.519 8.108 26.658
Mouse 25 (160) 0.56 0.673 0.371 0.471 0.521 0.657 1.115 1.553 4.68 16.229

HT-SELEX benchmarking auROC10 auPRC10 auROC25 auPRC25 auROC50 auPRC50
Methyl HT-SELEX, 1 experiments median 0.789 0.725 0.739 0.682 0.688 0.644
best 0.789 0.725 0.739 0.682 0.688 0.644

rSNP benchmarking, ADASTRA odds-ratio -log-Fisher's P Pearson r Kendall tau
# 1.384 0.332 0.101 0.053
TF superclassHelix-turn-helix domains {3} (TFClass)
TF classHomeo domain factors {3.1} (TFClass)
TF familyNK-related {3.1.2} (TFClass)
TF subfamilyNANOG {3.1.2.12} (TFClass)
TFClass IDTFClass: 3.1.2.12.1
HGNCHGNC:20857
MGIMGI:1919200
EntrezGene (human)GeneID:79923
(SSTAR profile)
EntrezGene (mouse)GeneID:71950
(SSTAR profile)
UniProt ID (human)NANOG_HUMAN
UniProt ID (mouse)NANOG_MOUSE
UniProt AC (human)Q9H9S0
(TFClass)
UniProt AC (mouse)Q80Z64
(TFClass)
GRECO-DB-TF
yes
ChIP-Seq 15 human, 25 mouse
HT-SELEX 0
Methyl-HT-SELEX 1
PCM
ACGT
011716.751019.751489.752462.75
021643.5301.54054.5689.5
03370.0102.0644.05573.0
040.02.00.06687.0
056331.00.0358.00.0
066688.00.01.00.0
071.0862.01037.04789.0
082.08.05600.01079.0
093070.0194.02254.01171.0
10789.5450.51715.53733.5
111139.5418.52159.52971.5
121764.25521.252015.252388.25
PFM
ACGT
010.2570.1520.2230.368
020.2460.0450.6060.103
030.0550.0150.0960.833
040.00.00.01.0
050.9460.00.0540.0
061.00.00.00.0
070.00.1290.1550.716
080.00.0010.8370.161
090.4590.0290.3370.175
100.1180.0670.2560.558
110.170.0630.3230.444
120.2640.0780.3010.357
PWM
ACGT
010.026-0.494-0.1150.387
02-0.017-1.7070.885-0.884
03-1.504-2.777-0.9521.203
04-6.634-5.988-6.6341.385
051.33-6.634-1.537-6.634
061.385-6.634-6.259-6.634
07-6.259-0.661-0.4771.051
08-5.988-5.1011.208-0.437
090.607-2.1440.298-0.356
10-0.749-1.3080.0260.802
11-0.383-1.3810.2550.574
120.053-1.1630.1860.356
Standard thresholds
P-value Threshold
0.001 4.64752
0.0005 5.66202
0.0001 7.493025