MotifMYCN.H12INVIVO.0.PS.A
Gene (human)MYCN
(GeneCards)
Gene synonyms (human)BHLHE37, NMYC
Gene (mouse)Mycn
Gene synonyms (mouse)Nmyc, Nmyc1
LOGO
LOGO (reverse complement)
Motif subtype0
Quality
A
Motif length11
ConsensusbYCACGTGbbb
GC content70.46%
Information content (bits; total / per base)11.508 / 1.046
Data sourcesChIP-Seq + HT-SELEX
Aligned words1000

ChIP-Seq benchmarking Num. of experiments (peaksets) auROC, median auROC, best auPRC, median auPRC, best pseudo-auROC, median pseudo-auROC, best pseudo-log-auROC, median pseudo-log-auROC, best Centrality, median Centrality, best
Human 23 (148) 0.842 0.951 0.749 0.894 0.777 0.921 2.584 3.614 146.163 424.824
Mouse 1 (7) 0.949 0.957 0.873 0.898 0.869 0.893 2.967 3.19 215.959 238.432

HT-SELEX benchmarking auROC10 auPRC10 auROC25 auPRC25 auROC50 auPRC50
Overall, 2 experiments median 0.688 0.646 0.623 0.598 0.581 0.567
best 0.738 0.703 0.648 0.629 0.593 0.585
Methyl HT-SELEX, 1 experiments median 0.637 0.589 0.599 0.567 0.569 0.549
best 0.637 0.589 0.599 0.567 0.569 0.549
Non-Methyl HT-SELEX, 1 experiments median 0.738 0.703 0.648 0.629 0.593 0.585
best 0.738 0.703 0.648 0.629 0.593 0.585

rSNP benchmarking, ADASTRA odds-ratio -log-Fisher's P Pearson r Kendall tau
# 13.959 15.085 0.38 0.188
TF superclassBasic domains {1} (TFClass)
TF classBasic helix-loop-helix factors (bHLH) {1.2} (TFClass)
TF familybHLH-ZIP {1.2.6} (TFClass)
TF subfamilyMYC {1.2.6.5} (TFClass)
TFClass IDTFClass: 1.2.6.5.2
HGNCHGNC:7559
MGIMGI:97357
EntrezGene (human)GeneID:4613
(SSTAR profile)
EntrezGene (mouse)GeneID:18109
(SSTAR profile)
UniProt ID (human)MYCN_HUMAN
UniProt ID (mouse)MYCN_MOUSE
UniProt AC (human)P04198
(TFClass)
UniProt AC (mouse)P03966
(TFClass)
GRECO-DB-TF
yes
ChIP-Seq 23 human, 1 mouse
HT-SELEX 1
Methyl-HT-SELEX 1
PCM
ACGT
01102.0175.0582.0141.0
0276.0772.064.088.0
0314.0985.00.01.0
04789.02.0103.0106.0
051.0885.04.0110.0
0626.018.0954.02.0
0720.074.01.0905.0
081.04.0986.09.0
0948.0446.0383.0123.0
10105.0176.0343.0376.0
1157.0525.0269.0149.0
PFM
ACGT
010.1020.1750.5820.141
020.0760.7720.0640.088
030.0140.9850.00.001
040.7890.0020.1030.106
050.0010.8850.0040.11
060.0260.0180.9540.002
070.020.0740.0010.905
080.0010.0040.9860.009
090.0480.4460.3830.123
100.1050.1760.3430.376
110.0570.5250.2690.149
PWM
ACGT
01-0.887-0.3540.841-0.567
02-1.1751.123-1.343-1.032
03-2.7731.366-4.982-4.525
041.145-4.213-0.877-0.849
05-4.5251.259-3.783-0.812
06-2.206-2.5461.334-4.213
07-2.45-1.201-4.5251.281
08-4.525-3.7831.367-3.156
09-1.6220.5760.424-0.702
10-0.858-0.3480.3140.406
11-1.4550.7380.073-0.513
Standard thresholds
P-value Threshold
0.001 4.31145
0.0005 5.34275
0.0001 7.338975