MotifMYCN.H12CORE.1.M.C
Gene (human)MYCN
(GeneCards)
Gene synonyms (human)BHLHE37, NMYC
Gene (mouse)Mycn
Gene synonyms (mouse)Nmyc, Nmyc1
LOGO
LOGO (reverse complement)
Motif subtype1
Quality
C
Motif length12
ConsensusnhhWCGCGCdYn
GC content62.81%
Information content (bits; total / per base)10.73 / 0.894
Data sourcesMethyl-HT-SELEX
Aligned words396

ChIP-Seq benchmarking Num. of experiments (peaksets) auROC, median auROC, best auPRC, median auPRC, best pseudo-auROC, median pseudo-auROC, best pseudo-log-auROC, median pseudo-log-auROC, best Centrality, median Centrality, best
Human 23 (148) 0.662 0.734 0.475 0.544 0.518 0.652 1.158 1.506 7.517 18.161
Mouse 1 (7) 0.586 0.632 0.445 0.482 0.293 0.394 0.635 0.907 10.432 13.495

HT-SELEX benchmarking auROC10 auPRC10 auROC25 auPRC25 auROC50 auPRC50
Overall, 2 experiments median 0.76 0.697 0.693 0.648 0.632 0.606
best 0.78 0.714 0.706 0.661 0.641 0.616
Methyl HT-SELEX, 1 experiments median 0.741 0.679 0.679 0.635 0.622 0.597
best 0.741 0.679 0.679 0.635 0.622 0.597
Non-Methyl HT-SELEX, 1 experiments median 0.78 0.714 0.706 0.661 0.641 0.616
best 0.78 0.714 0.706 0.661 0.641 0.616

rSNP benchmarking, ADASTRA odds-ratio -log-Fisher's P Pearson r Kendall tau
# 1.55 0.984 0.14 0.026
TF superclassBasic domains {1} (TFClass)
TF classBasic helix-loop-helix factors (bHLH) {1.2} (TFClass)
TF familybHLH-ZIP {1.2.6} (TFClass)
TF subfamilyMYC {1.2.6.5} (TFClass)
TFClass IDTFClass: 1.2.6.5.2
HGNCHGNC:7559
MGIMGI:97357
EntrezGene (human)GeneID:4613
(SSTAR profile)
EntrezGene (mouse)GeneID:18109
(SSTAR profile)
UniProt ID (human)MYCN_HUMAN
UniProt ID (mouse)MYCN_MOUSE
UniProt AC (human)P04198
(TFClass)
UniProt AC (mouse)P03966
(TFClass)
GRECO-DB-TF
yes
ChIP-Seq 23 human, 1 mouse
HT-SELEX 1
Methyl-HT-SELEX 1
PCM
ACGT
0197.0107.086.0106.0
0251.5112.550.5181.5
0388.5111.512.5183.5
04235.037.00.0124.0
050.0387.00.09.0
060.09.0387.00.0
070.0396.00.00.0
080.00.0394.02.0
090.0241.00.0155.0
1080.7540.75213.7560.75
1145.25173.259.25168.25
1285.2580.25136.2594.25
PFM
ACGT
010.2450.270.2170.268
020.130.2840.1280.458
030.2230.2820.0320.463
040.5930.0930.00.313
050.00.9770.00.023
060.00.0230.9770.0
070.01.00.00.0
080.00.00.9950.005
090.00.6090.00.391
100.2040.1030.540.153
110.1140.4380.0230.425
120.2150.2030.3440.238
PWM
ACGT
01-0.020.077-0.1390.067
02-0.640.126-0.6590.599
03-0.110.117-1.9710.61
040.856-0.96-4.2080.222
05-4.2081.352-4.208-2.259
06-4.208-2.2591.352-4.208
07-4.2081.375-4.208-4.208
08-4.208-4.2081.37-3.359
09-4.2080.881-4.2080.443
10-0.2-0.8670.762-0.479
11-0.7650.553-2.2360.524
12-0.147-0.2070.315-0.048
Standard thresholds
P-value Threshold
0.001 4.52411
0.0005 5.878085
0.0001 7.68435