MLX.H12RSNP.1.SM.B motif - HOmo sapiens COmprehensive MOdel COllection

Motif	MLX.H12RSNP.1.SM.B
Gene (human)	MLX (GeneCards)
Gene synonyms (human)	BHLHD13, TCFL4
Gene (mouse)	Mlx
Gene synonyms (mouse)	Tcfl4
LOGO
LOGO (reverse complement)
Motif subtype	1
Quality	B

Motif length	13
Consensus	nbCACGTGWYhnn
GC content	50.39%
Information content (bits; total / per base)	13.819 / 1.063
Data sources	HT-SELEX + Methyl-HT-SELEX
Aligned words	627

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Human	1 (7)	0.668	0.707	0.617	0.663	0.664	0.709	2.266	2.532	142.276	218.824

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 10 experiments	median	0.993	0.989	0.978	0.975	0.942	0.923
Overall, 10 experiments	best	0.999	0.998	0.997	0.994	0.996	0.993
Methyl HT-SELEX, 3 experiments	median	0.993	0.988	0.985	0.977	0.968	0.955
Methyl HT-SELEX, 3 experiments	best	0.994	0.99	0.99	0.984	0.969	0.96
Non-Methyl HT-SELEX, 7 experiments	median	0.995	0.992	0.972	0.973	0.748	0.798
Non-Methyl HT-SELEX, 7 experiments	best	0.999	0.998	0.997	0.994	0.996	0.993

rSNP benchmarking, SNP-SELEX	auROC	auPRC	Pearson r	Kendall tau
batch 2	0.913	0.853	0.875	0.678

TF superclass	Basic domains {1} (TFClass)
TF class	Basic helix-loop-helix factors (bHLH) {1.2} (TFClass)
TF family	bHLH-ZIP {1.2.6} (TFClass)
TF subfamily	MONDOlike {1.2.6.6} (TFClass)
TFClass ID	TFClass: 1.2.6.6.1
HGNC	HGNC:11645
MGI	MGI:108398
EntrezGene (human)	GeneID:6945 (SSTAR profile)
EntrezGene (mouse)	GeneID:21428 (SSTAR profile)
UniProt ID (human)	MLX_HUMAN
UniProt ID (mouse)	MLX_MOUSE
UniProt AC (human)	Q9UH92 (TFClass)
UniProt AC (mouse)	O08609 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	1 human, 0 mouse
HT-SELEX	7
Methyl-HT-SELEX	3

PCM	MLX.H12RSNP.1.SM.B.pcm
PWM	MLX.H12RSNP.1.SM.B.pwm
PFM	MLX.H12RSNP.1.SM.B.pfm
Alignment	MLX.H12RSNP.1.SM.B.words.tsv
Threshold to P-value map	MLX.H12RSNP.1.SM.B.thr
Motif in other formats
JASPAR format	MLX.H12RSNP.1.SM.B_jaspar_format.txt
MEME format	MLX.H12RSNP.1.SM.B_meme_format.meme
Transfac format	MLX.H12RSNP.1.SM.B_transfac_format.txt
Homer format	MLX.H12RSNP.1.SM.B_homer_format_0.001.txt MLX.H12RSNP.1.SM.B_homer_format_0.0005.txt MLX.H12RSNP.1.SM.B_homer_format_0.0001.txt

PCM

	A	C	G	T
01	150.5	118.5	178.5	179.5
02	86.25	113.25	93.25	334.25
03	0.0	627.0	0.0	0.0
04	627.0	0.0	0.0	0.0
05	0.0	627.0	0.0	0.0
06	0.0	0.0	627.0	0.0
07	0.0	0.0	0.0	627.0
08	0.0	0.0	627.0	0.0
09	410.0	88.0	22.0	107.0
10	37.0	158.0	23.0	409.0
11	196.75	234.75	39.75	155.75
12	223.0	115.0	126.0	163.0
13	173.0	165.0	124.0	165.0

PFM

	A	C	G	T
01	0.24	0.189	0.285	0.286
02	0.138	0.181	0.149	0.533
03	0.0	1.0	0.0	0.0
04	1.0	0.0	0.0	0.0
05	0.0	1.0	0.0	0.0
06	0.0	0.0	1.0	0.0
07	0.0	0.0	0.0	1.0
08	0.0	0.0	1.0	0.0
09	0.654	0.14	0.035	0.171
10	0.059	0.252	0.037	0.652
11	0.314	0.374	0.063	0.248
12	0.356	0.183	0.201	0.26
13	0.276	0.263	0.198	0.263

PWM

	A	C	G	T
01	-0.04	-0.276	0.129	0.134
02	-0.589	-0.321	-0.512	0.752
03	-4.588	1.379	-4.588	-4.588
04	1.379	-4.588	-4.588	-4.588
05	-4.588	1.379	-4.588	-4.588
06	-4.588	-4.588	1.379	-4.588
07	-4.588	-4.588	-4.588	1.379
08	-4.588	-4.588	1.379	-4.588
09	0.955	-0.569	-1.903	-0.377
10	-1.411	0.008	-1.862	0.953
11	0.225	0.4	-1.343	-0.006
12	0.349	-0.306	-0.216	0.039
13	0.098	0.051	-0.232	0.051

Standard thresholds

P-value	Threshold
0.001	2.60987
0.0005	3.69292
0.0001	7.242555