MLX.H12RSNP.0.PM.A motif - HOmo sapiens COmprehensive MOdel COllection

Motif	MLX.H12RSNP.0.PM.A
Gene (human)	MLX (GeneCards)
Gene synonyms (human)	BHLHD13, TCFL4
Gene (mouse)	Mlx
Gene synonyms (mouse)	Tcfl4
LOGO
LOGO (reverse complement)
Motif subtype	0
Quality	A

Motif length	16
Consensus	dddCACGTGATMWhdn
GC content	49.49%
Information content (bits; total / per base)	16.005 / 1.0
Data sources	ChIP-Seq + Methyl-HT-SELEX
Aligned words	287

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Human	1 (7)	0.67	0.692	0.588	0.621	0.685	0.712	2.113	2.298	111.62	156.921

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 10 experiments	median	0.994	0.99	0.986	0.978	0.962	0.951
Overall, 10 experiments	best	0.998	0.997	0.996	0.994	0.994	0.99
Methyl HT-SELEX, 3 experiments	median	0.994	0.99	0.991	0.985	0.975	0.966
Methyl HT-SELEX, 3 experiments	best	0.995	0.991	0.992	0.986	0.983	0.975
Non-Methyl HT-SELEX, 7 experiments	median	0.994	0.99	0.937	0.938	0.743	0.779
Non-Methyl HT-SELEX, 7 experiments	best	0.998	0.997	0.996	0.994	0.994	0.99

rSNP benchmarking, SNP-SELEX	auROC	auPRC	Pearson r	Kendall tau
batch 2	0.848	0.541	0.848	0.632

TF superclass	Basic domains {1} (TFClass)
TF class	Basic helix-loop-helix factors (bHLH) {1.2} (TFClass)
TF family	bHLH-ZIP {1.2.6} (TFClass)
TF subfamily	MONDOlike {1.2.6.6} (TFClass)
TFClass ID	TFClass: 1.2.6.6.1
HGNC	HGNC:11645
MGI	MGI:108398
EntrezGene (human)	GeneID:6945 (SSTAR profile)
EntrezGene (mouse)	GeneID:21428 (SSTAR profile)
UniProt ID (human)	MLX_HUMAN
UniProt ID (mouse)	MLX_MOUSE
UniProt AC (human)	Q9UH92 (TFClass)
UniProt AC (mouse)	O08609 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	1 human, 0 mouse
HT-SELEX	7
Methyl-HT-SELEX	3

PCM	MLX.H12RSNP.0.PM.A.pcm
PWM	MLX.H12RSNP.0.PM.A.pwm
PFM	MLX.H12RSNP.0.PM.A.pfm
Alignment	MLX.H12RSNP.0.PM.A.words.tsv
Threshold to P-value map	MLX.H12RSNP.0.PM.A.thr
Motif in other formats
JASPAR format	MLX.H12RSNP.0.PM.A_jaspar_format.txt
MEME format	MLX.H12RSNP.0.PM.A_meme_format.meme
Transfac format	MLX.H12RSNP.0.PM.A_transfac_format.txt
Homer format	MLX.H12RSNP.0.PM.A_homer_format_0.001.txt MLX.H12RSNP.0.PM.A_homer_format_0.0005.txt MLX.H12RSNP.0.PM.A_homer_format_0.0001.txt

PCM

	A	C	G	T
01	59.0	38.0	100.0	90.0
02	138.5	18.5	75.5	54.5
03	48.0	24.0	88.0	127.0
04	1.0	286.0	0.0	0.0
05	287.0	0.0	0.0	0.0
06	0.0	235.0	0.0	52.0
07	3.0	0.0	284.0	0.0
08	0.0	0.0	0.0	287.0
09	0.0	0.0	287.0	0.0
10	256.0	31.0	0.0	0.0
11	14.0	41.0	4.0	228.0
12	44.0	207.0	0.0	36.0
13	172.0	26.0	35.0	54.0
14	57.0	127.0	42.0	61.0
15	54.0	45.0	142.0	46.0
16	52.25	77.25	59.25	98.25

PFM

	A	C	G	T
01	0.206	0.132	0.348	0.314
02	0.483	0.064	0.263	0.19
03	0.167	0.084	0.307	0.443
04	0.003	0.997	0.0	0.0
05	1.0	0.0	0.0	0.0
06	0.0	0.819	0.0	0.181
07	0.01	0.0	0.99	0.0
08	0.0	0.0	0.0	1.0
09	0.0	0.0	1.0	0.0
10	0.892	0.108	0.0	0.0
11	0.049	0.143	0.014	0.794
12	0.153	0.721	0.0	0.125
13	0.599	0.091	0.122	0.188
14	0.199	0.443	0.146	0.213
15	0.188	0.157	0.495	0.16
16	0.182	0.269	0.206	0.342

PWM

	A	C	G	T
01	-0.191	-0.619	0.327	0.223
02	0.648	-1.301	0.05	-0.269
03	-0.392	-1.057	0.201	0.563
04	-3.411	1.368	-3.946	-3.946
05	1.372	-3.946	-3.946	-3.946
06	-3.946	1.173	-3.946	-0.315
07	-2.808	-3.946	1.361	-3.946
08	-3.946	-3.946	-3.946	1.372
09	-3.946	-3.946	1.372	-3.946
10	1.258	-0.814	-3.946	-3.946
11	-1.557	-0.545	-2.604	1.143
12	-0.477	1.047	-3.946	-0.671
13	0.863	-0.982	-0.698	-0.278
14	-0.225	0.563	-0.522	-0.159
15	-0.278	-0.455	0.673	-0.434
16	-0.31	0.072	-0.187	0.309

Standard thresholds

P-value	Threshold
0.001	2.29436
0.0005	3.63276
0.0001	6.33426