MLX.H12INVIVO.1.SM.B motif - HOmo sapiens COmprehensive MOdel COllection

Motif	MLX.H12INVIVO.1.SM.B
Gene (human)	MLX (GeneCards)
Gene synonyms (human)	BHLHD13, TCFL4
Gene (mouse)	Mlx
Gene synonyms (mouse)	Tcfl4
LOGO
LOGO (reverse complement)
Motif subtype	1
Quality	B

Motif length	13
Consensus	nnCACGTGMhhnn
GC content	57.2%
Information content (bits; total / per base)	13.309 / 1.024
Data sources	HT-SELEX + Methyl-HT-SELEX
Aligned words	2442

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Human	1 (7)	0.775	0.809	0.682	0.733	0.703	0.743	2.382	2.664	157.921	235.194

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 10 experiments	median	0.992	0.986	0.98	0.976	0.97	0.954
Overall, 10 experiments	best	0.998	0.997	0.997	0.994	0.996	0.993
Methyl HT-SELEX, 3 experiments	median	0.992	0.986	0.986	0.978	0.982	0.971
Methyl HT-SELEX, 3 experiments	best	0.992	0.986	0.99	0.982	0.982	0.973
Non-Methyl HT-SELEX, 7 experiments	median	0.994	0.99	0.973	0.973	0.771	0.809
Non-Methyl HT-SELEX, 7 experiments	best	0.998	0.997	0.997	0.994	0.996	0.993

rSNP benchmarking, SNP-SELEX	auROC	auPRC	Pearson r	Kendall tau
batch 2	0.875	0.701	0.844	0.628

TF superclass	Basic domains {1} (TFClass)
TF class	Basic helix-loop-helix factors (bHLH) {1.2} (TFClass)
TF family	bHLH-ZIP {1.2.6} (TFClass)
TF subfamily	MONDOlike {1.2.6.6} (TFClass)
TFClass ID	TFClass: 1.2.6.6.1
HGNC	HGNC:11645
MGI	MGI:108398
EntrezGene (human)	GeneID:6945 (SSTAR profile)
EntrezGene (mouse)	GeneID:21428 (SSTAR profile)
UniProt ID (human)	MLX_HUMAN
UniProt ID (mouse)	MLX_MOUSE
UniProt AC (human)	Q9UH92 (TFClass)
UniProt AC (mouse)	O08609 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	1 human, 0 mouse
HT-SELEX	7
Methyl-HT-SELEX	3

PCM	MLX.H12INVIVO.1.SM.B.pcm
PWM	MLX.H12INVIVO.1.SM.B.pwm
PFM	MLX.H12INVIVO.1.SM.B.pfm
Alignment	MLX.H12INVIVO.1.SM.B.words.tsv
Threshold to P-value map	MLX.H12INVIVO.1.SM.B.thr
Motif in other formats
JASPAR format	MLX.H12INVIVO.1.SM.B_jaspar_format.txt
MEME format	MLX.H12INVIVO.1.SM.B_meme_format.meme
Transfac format	MLX.H12INVIVO.1.SM.B_transfac_format.txt
Homer format	MLX.H12INVIVO.1.SM.B_homer_format_0.001.txt MLX.H12INVIVO.1.SM.B_homer_format_0.0005.txt MLX.H12INVIVO.1.SM.B_homer_format_0.0001.txt

PCM

	A	C	G	T
01	677.0	652.0	534.0	579.0
02	367.0	799.0	472.0	804.0
03	22.0	2417.0	1.0	2.0
04	2439.0	0.0	1.0	2.0
05	0.0	2375.0	0.0	67.0
06	6.0	0.0	2436.0	0.0
07	0.0	0.0	1.0	2441.0
08	0.0	0.0	2432.0	10.0
09	1415.0	907.0	81.0	39.0
10	298.0	835.0	101.0	1208.0
11	445.0	1360.0	189.0	448.0
12	786.75	646.75	524.75	483.75
13	502.25	878.25	515.25	546.25

PFM

	A	C	G	T
01	0.277	0.267	0.219	0.237
02	0.15	0.327	0.193	0.329
03	0.009	0.99	0.0	0.001
04	0.999	0.0	0.0	0.001
05	0.0	0.973	0.0	0.027
06	0.002	0.0	0.998	0.0
07	0.0	0.0	0.0	1.0
08	0.0	0.0	0.996	0.004
09	0.579	0.371	0.033	0.016
10	0.122	0.342	0.041	0.495
11	0.182	0.557	0.077	0.183
12	0.322	0.265	0.215	0.198
13	0.206	0.36	0.211	0.224

PWM

	A	C	G	T
01	0.103	0.066	-0.133	-0.053
02	-0.507	0.268	-0.256	0.275
03	-3.241	1.374	-5.336	-5.044
04	1.383	-5.75	-5.336	-5.044
05	-5.75	1.356	-5.75	-2.184
06	-4.344	-5.75	1.381	-5.75
07	-5.75	-5.75	-5.336	1.383
08	-5.75	-5.75	1.38	-3.937
09	0.839	0.395	-1.999	-2.705
10	-0.714	0.312	-1.783	0.681
11	-0.315	0.799	-1.165	-0.308
12	0.253	0.058	-0.151	-0.232
13	-0.194	0.363	-0.169	-0.111

Standard thresholds

P-value	Threshold
0.001	2.365665
0.0005	3.588265
0.0001	7.222825