MLX.H12CORE.1.SM.B motif - HOmo sapiens COmprehensive MOdel COllection

Motif	MLX.H12CORE.1.SM.B
Gene (human)	MLX (GeneCards)
Gene synonyms (human)	BHLHD13, TCFL4
Gene (mouse)	Mlx
Gene synonyms (mouse)	Tcfl4
LOGO
LOGO (reverse complement)
Motif subtype	1
Quality	B

Motif length	11
Consensus	nCACGTGMhhn
GC content	57.01%
Information content (bits; total / per base)	12.811 / 1.165
Data sources	HT-SELEX + Methyl-HT-SELEX
Aligned words	9417

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Human	1 (7)	0.768	0.802	0.678	0.727	0.709	0.747	2.378	2.641	164.143	240.252

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 10 experiments	median	0.993	0.988	0.987	0.982	0.976	0.961
Overall, 10 experiments	best	0.999	0.998	0.997	0.994	0.996	0.993
Methyl HT-SELEX, 3 experiments	median	0.993	0.988	0.988	0.98	0.985	0.975
Methyl HT-SELEX, 3 experiments	best	0.993	0.989	0.99	0.984	0.985	0.976
Non-Methyl HT-SELEX, 7 experiments	median	0.995	0.991	0.987	0.986	0.797	0.829
Non-Methyl HT-SELEX, 7 experiments	best	0.999	0.998	0.997	0.994	0.996	0.993

rSNP benchmarking, SNP-SELEX	auROC	auPRC	Pearson r	Kendall tau
batch 2	0.87	0.624	0.834	0.615

TF superclass	Basic domains {1} (TFClass)
TF class	Basic helix-loop-helix factors (bHLH) {1.2} (TFClass)
TF family	bHLH-ZIP {1.2.6} (TFClass)
TF subfamily	MONDOlike {1.2.6.6} (TFClass)
TFClass ID	TFClass: 1.2.6.6.1
HGNC	HGNC:11645
MGI	MGI:108398
EntrezGene (human)	GeneID:6945 (SSTAR profile)
EntrezGene (mouse)	GeneID:21428 (SSTAR profile)
UniProt ID (human)	MLX_HUMAN
UniProt ID (mouse)	MLX_MOUSE
UniProt AC (human)	Q9UH92 (TFClass)
UniProt AC (mouse)	O08609 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	1 human, 0 mouse
HT-SELEX	7
Methyl-HT-SELEX	3

PCM	MLX.H12CORE.1.SM.B.pcm
PWM	MLX.H12CORE.1.SM.B.pwm
PFM	MLX.H12CORE.1.SM.B.pfm
Alignment	MLX.H12CORE.1.SM.B.words.tsv
Threshold to P-value map	MLX.H12CORE.1.SM.B.thr
Motif in other formats
JASPAR format	MLX.H12CORE.1.SM.B_jaspar_format.txt
MEME format	MLX.H12CORE.1.SM.B_meme_format.meme
Transfac format	MLX.H12CORE.1.SM.B_transfac_format.txt
Homer format	MLX.H12CORE.1.SM.B_homer_format_0.001.txt MLX.H12CORE.1.SM.B_homer_format_0.0005.txt MLX.H12CORE.1.SM.B_homer_format_0.0001.txt

PCM

	A	C	G	T
01	1618.75	3106.75	2349.75	2341.75
02	48.25	9339.25	13.25	16.25
03	9374.0	4.0	23.0	16.0
04	0.0	8730.0	6.0	681.0
05	120.0	9.0	9288.0	0.0
06	0.0	0.0	0.0	9417.0
07	6.0	9.0	9357.0	45.0
08	6020.0	2877.0	303.0	217.0
09	1221.0	2741.0	432.0	5023.0
10	2068.25	4747.25	996.25	1605.25
11	2907.75	2473.75	2245.75	1789.75

PFM

	A	C	G	T
01	0.172	0.33	0.25	0.249
02	0.005	0.992	0.001	0.002
03	0.995	0.0	0.002	0.002
04	0.0	0.927	0.001	0.072
05	0.013	0.001	0.986	0.0
06	0.0	0.0	0.0	1.0
07	0.001	0.001	0.994	0.005
08	0.639	0.306	0.032	0.023
09	0.13	0.291	0.046	0.533
10	0.22	0.504	0.106	0.17
11	0.309	0.263	0.238	0.19

PWM

	A	C	G	T
01	-0.374	0.277	-0.002	-0.005
02	-3.842	1.377	-5.022	-4.845
03	1.381	-5.926	-4.535	-4.859
04	-6.937	1.31	-5.65	-1.238
05	-2.959	-5.341	1.372	-6.937
06	-6.937	-6.937	-6.937	1.386
07	-5.65	-5.341	1.379	-3.909
08	0.938	0.2	-2.044	-2.375
09	-0.656	0.152	-1.691	0.757
10	-0.129	0.701	-0.859	-0.382
11	0.211	0.049	-0.047	-0.274

Standard thresholds

P-value	Threshold
0.001	2.55467
0.0005	3.96002
0.0001	7.442815