MLX.H12CORE.0.PM.A motif - HOmo sapiens COmprehensive MOdel COllection

Motif	MLX.H12CORE.0.PM.A
Gene (human)	MLX (GeneCards)
Gene synonyms (human)	BHLHD13, TCFL4
Gene (mouse)	Mlx
Gene synonyms (mouse)	Tcfl4
LOGO
LOGO (reverse complement)
Motif subtype	0
Quality	A

Motif length	9
Consensus	CMYbTGvhh
GC content	56.85%
Information content (bits; total / per base)	7.642 / 0.849
Data sources	ChIP-Seq + Methyl-HT-SELEX
Aligned words	876

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Human	1 (7)	0.778	0.804	0.684	0.718	0.728	0.76	2.308	2.474	133.602	192.137

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 10 experiments	median	0.993	0.988	0.99	0.984	0.981	0.974
Overall, 10 experiments	best	0.999	0.998	0.997	0.995	0.995	0.991
Methyl HT-SELEX, 3 experiments	median	0.993	0.988	0.99	0.983	0.98	0.971
Methyl HT-SELEX, 3 experiments	best	0.993	0.988	0.99	0.984	0.985	0.976
Non-Methyl HT-SELEX, 7 experiments	median	0.994	0.99	0.991	0.985	0.981	0.977
Non-Methyl HT-SELEX, 7 experiments	best	0.999	0.998	0.997	0.995	0.995	0.991

rSNP benchmarking, SNP-SELEX	auROC	auPRC	Pearson r	Kendall tau
batch 2	0.751	0.383	0.764	0.578

TF superclass	Basic domains {1} (TFClass)
TF class	Basic helix-loop-helix factors (bHLH) {1.2} (TFClass)
TF family	bHLH-ZIP {1.2.6} (TFClass)
TF subfamily	MONDOlike {1.2.6.6} (TFClass)
TFClass ID	TFClass: 1.2.6.6.1
HGNC	HGNC:11645
MGI	MGI:108398
EntrezGene (human)	GeneID:6945 (SSTAR profile)
EntrezGene (mouse)	GeneID:21428 (SSTAR profile)
UniProt ID (human)	MLX_HUMAN
UniProt ID (mouse)	MLX_MOUSE
UniProt AC (human)	Q9UH92 (TFClass)
UniProt AC (mouse)	O08609 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	1 human, 0 mouse
HT-SELEX	7
Methyl-HT-SELEX	3

PCM	MLX.H12CORE.0.PM.A.pcm
PWM	MLX.H12CORE.0.PM.A.pwm
PFM	MLX.H12CORE.0.PM.A.pfm
Alignment	MLX.H12CORE.0.PM.A.words.tsv
Threshold to P-value map	MLX.H12CORE.0.PM.A.thr
Motif in other formats
JASPAR format	MLX.H12CORE.0.PM.A_jaspar_format.txt
MEME format	MLX.H12CORE.0.PM.A_meme_format.meme
Transfac format	MLX.H12CORE.0.PM.A_transfac_format.txt
Homer format	MLX.H12CORE.0.PM.A_homer_format_0.001.txt MLX.H12CORE.0.PM.A_homer_format_0.0005.txt MLX.H12CORE.0.PM.A_homer_format_0.0001.txt

PCM

	A	C	G	T
01	84.0	725.0	18.0	49.0
02	558.0	197.0	71.0	50.0
03	11.0	484.0	24.0	357.0
04	16.0	102.0	656.0	102.0
05	5.0	1.0	2.0	868.0
06	8.0	4.0	854.0	10.0
07	383.0	145.0	249.0	99.0
08	179.0	340.0	72.0	285.0
09	170.0	454.0	84.0	168.0

PFM

	A	C	G	T
01	0.096	0.828	0.021	0.056
02	0.637	0.225	0.081	0.057
03	0.013	0.553	0.027	0.408
04	0.018	0.116	0.749	0.116
05	0.006	0.001	0.002	0.991
06	0.009	0.005	0.975	0.011
07	0.437	0.166	0.284	0.113
08	0.204	0.388	0.082	0.325
09	0.194	0.518	0.096	0.192

PWM

	A	C	G	T
01	-0.946	1.192	-2.416	-1.471
02	0.931	-0.105	-1.111	-1.451
03	-2.856	0.789	-2.151	0.486
04	-2.524	-0.755	1.092	-0.755
05	-3.496	-4.406	-4.09	1.371
06	-3.125	-3.657	1.355	-2.938
07	0.556	-0.408	0.127	-0.785
08	-0.2	0.437	-1.097	0.262
09	-0.251	0.725	-0.946	-0.263

Standard thresholds

P-value	Threshold
0.001	5.18258
0.0005	5.864705
0.0001	7.020525