MIXL1.H12CORE.0.SM.B motif - HOmo sapiens COmprehensive MOdel COllection

Motif	MIXL1.H12CORE.0.SM.B
Gene (human)	MIXL1 (GeneCards)
Gene synonyms (human)	MIXL
Gene (mouse)	Mixl1
Gene synonyms (mouse)	Mix, Mml
LOGO
LOGO (reverse complement)
Motif subtype	0
Quality	B

Motif length	16
Consensus	nvbTAATTAGATTAvn
GC content	23.7%
Information content (bits; total / per base)	19.396 / 1.212
Data sources	HT-SELEX + Methyl-HT-SELEX
Aligned words	7953

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 4 experiments	median	0.976	0.966	0.943	0.929	0.89	0.879
Overall, 4 experiments	best	0.999	0.999	0.999	0.998	0.997	0.996
Methyl HT-SELEX, 1 experiments	median	0.999	0.999	0.999	0.998	0.997	0.996
Methyl HT-SELEX, 1 experiments	best	0.999	0.999	0.999	0.998	0.997	0.996
Non-Methyl HT-SELEX, 3 experiments	median	0.953	0.933	0.889	0.861	0.792	0.773
Non-Methyl HT-SELEX, 3 experiments	best	0.999	0.998	0.998	0.996	0.988	0.985

rSNP benchmarking, SNP-SELEX	auROC	auPRC	Pearson r	Kendall tau
batch 1	0.951	0.379	0.946	0.656
batch 2	0.72	0.441	0.745	0.535

TF superclass	Helix-turn-helix domains {3} (TFClass)
TF class	Homeo domain factors {3.1} (TFClass)
TF family	Paired-related HD {3.1.3} (TFClass)
TF subfamily	MIX {3.1.3.14} (TFClass)
TFClass ID	TFClass: 3.1.3.14.1
HGNC	HGNC:13363
MGI	MGI:1351322
EntrezGene (human)	GeneID:83881 (SSTAR profile)
EntrezGene (mouse)	GeneID:27217 (SSTAR profile)
UniProt ID (human)	MIXL1_HUMAN
UniProt ID (mouse)	MIXL1_MOUSE
UniProt AC (human)	Q9H2W2 (TFClass)
UniProt AC (mouse)	Q9WUI0 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	0 human, 0 mouse
HT-SELEX	3
Methyl-HT-SELEX	1

PCM	MIXL1.H12CORE.0.SM.B.pcm
PWM	MIXL1.H12CORE.0.SM.B.pwm
PFM	MIXL1.H12CORE.0.SM.B.pfm
Alignment	MIXL1.H12CORE.0.SM.B.words.tsv
Threshold to P-value map	MIXL1.H12CORE.0.SM.B.thr
Motif in other formats
JASPAR format	MIXL1.H12CORE.0.SM.B_jaspar_format.txt
MEME format	MIXL1.H12CORE.0.SM.B_meme_format.meme
Transfac format	MIXL1.H12CORE.0.SM.B_transfac_format.txt
Homer format	MIXL1.H12CORE.0.SM.B_homer_format_0.001.txt MIXL1.H12CORE.0.SM.B_homer_format_0.0005.txt MIXL1.H12CORE.0.SM.B_homer_format_0.0001.txt

PCM

	A	C	G	T
01	2279.75	2228.75	1748.75	1695.75
02	1977.5	1516.5	3440.5	1018.5
03	887.0	2687.0	1263.0	3116.0
04	58.0	56.0	13.0	7826.0
05	7762.0	2.0	185.0	4.0
06	7953.0	0.0	0.0	0.0
07	0.0	10.0	0.0	7943.0
08	0.0	65.0	39.0	7849.0
09	6819.0	148.0	847.0	139.0
10	1460.0	407.0	6084.0	2.0
11	7417.0	42.0	447.0	47.0
12	2.0	18.0	15.0	7918.0
13	23.0	301.0	13.0	7616.0
14	7721.0	29.0	86.0	117.0
15	3037.75	1449.75	2384.75	1080.75
16	1239.25	3007.25	1620.25	2086.25

PFM

	A	C	G	T
01	0.287	0.28	0.22	0.213
02	0.249	0.191	0.433	0.128
03	0.112	0.338	0.159	0.392
04	0.007	0.007	0.002	0.984
05	0.976	0.0	0.023	0.001
06	1.0	0.0	0.0	0.0
07	0.0	0.001	0.0	0.999
08	0.0	0.008	0.005	0.987
09	0.857	0.019	0.107	0.017
10	0.184	0.051	0.765	0.0
11	0.933	0.005	0.056	0.006
12	0.0	0.002	0.002	0.996
13	0.003	0.038	0.002	0.958
14	0.971	0.004	0.011	0.015
15	0.382	0.182	0.3	0.136
16	0.156	0.378	0.204	0.262

PWM

	A	C	G	T
01	0.137	0.114	-0.128	-0.159
02	-0.005	-0.27	0.548	-0.668
03	-0.806	0.301	-0.453	0.449
04	-3.498	-3.531	-4.872	1.369
05	1.361	-6.15	-2.364	-5.764
06	1.385	-6.787	-6.787	-6.787
07	-6.787	-5.091	-6.787	1.384
08	-6.787	-3.388	-3.877	1.372
09	1.232	-2.584	-0.852	-2.646
10	-0.308	-1.582	1.118	-6.15
11	1.316	-3.806	-1.489	-3.699
12	-6.15	-4.588	-4.749	1.381
13	-4.367	-1.882	-4.872	1.342
14	1.356	-4.154	-3.116	-2.815
15	0.423	-0.315	0.182	-0.609
16	-0.472	0.413	-0.204	0.048

Standard thresholds

P-value	Threshold
0.001	-2.06819
0.0005	-0.23934
0.0001	3.58521