MEF2D.H12INVIVO.0.PS.A motif - HOmo sapiens COmprehensive MOdel COllection

Motif	MEF2D.H12INVIVO.0.PS.A
Gene (human)	MEF2D (GeneCards)
Gene synonyms (human)
Gene (mouse)	Mef2d
Gene synonyms (mouse)
LOGO
LOGO (reverse complement)
Motif subtype	0
Quality	A

Motif length	15
Consensus	dddCTATTTWTARhh
GC content	30.18%
Information content (bits; total / per base)	13.942 / 0.929
Data sources	ChIP-Seq + HT-SELEX
Aligned words	1022

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Human	1 (7)	0.696	0.726	0.663	0.683	0.799	0.815	3.822	3.926	105.398	131.569
Mouse	8 (46)	0.931	0.958	0.888	0.926	0.954	0.977	5.248	5.849	290.829	607.678

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 3 experiments	median	0.758	0.719	0.597	0.639	0.527	0.58
Overall, 3 experiments	best	0.818	0.843	0.658	0.658	0.584	0.586
Methyl HT-SELEX, 1 experiments	median	0.758	0.719	0.658	0.639	0.584	0.586
Methyl HT-SELEX, 1 experiments	best	0.758	0.719	0.658	0.639	0.584	0.586
Non-Methyl HT-SELEX, 2 experiments	median	0.735	0.761	0.574	0.621	0.522	0.562
Non-Methyl HT-SELEX, 2 experiments	best	0.818	0.843	0.597	0.658	0.527	0.58

TF superclass	alpha-Helices exposed by beta-structures {5} (TFClass)
TF class	MADS box factors {5.1} (TFClass)
TF family	Regulators of differentiation {5.1.1} (TFClass)
TF subfamily	MEF2 {5.1.1.1} (TFClass)
TFClass ID	TFClass: 5.1.1.1.4
HGNC	HGNC:6997
MGI	MGI:99533
EntrezGene (human)	GeneID:4209 (SSTAR profile)
EntrezGene (mouse)	GeneID:17261 (SSTAR profile)
UniProt ID (human)	MEF2D_HUMAN
UniProt ID (mouse)	MEF2D_MOUSE
UniProt AC (human)	Q14814 (TFClass)
UniProt AC (mouse)	Q63943 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	1 human, 8 mouse
HT-SELEX	2
Methyl-HT-SELEX	1

PCM	MEF2D.H12INVIVO.0.PS.A.pcm
PWM	MEF2D.H12INVIVO.0.PS.A.pwm
PFM	MEF2D.H12INVIVO.0.PS.A.pfm
Alignment	MEF2D.H12INVIVO.0.PS.A.words.tsv
Threshold to P-value map	MEF2D.H12INVIVO.0.PS.A.thr
Motif in other formats
JASPAR format	MEF2D.H12INVIVO.0.PS.A_jaspar_format.txt
MEME format	MEF2D.H12INVIVO.0.PS.A_meme_format.meme
Transfac format	MEF2D.H12INVIVO.0.PS.A_transfac_format.txt
Homer format	MEF2D.H12INVIVO.0.PS.A_homer_format_0.001.txt MEF2D.H12INVIVO.0.PS.A_homer_format_0.0005.txt MEF2D.H12INVIVO.0.PS.A_homer_format_0.0001.txt

PCM

	A	C	G	T
01	260.0	149.0	391.0	222.0
02	315.0	53.0	316.0	338.0
03	107.0	59.0	528.0	328.0
04	33.0	816.0	42.0	131.0
05	4.0	17.0	0.0	1001.0
06	1001.0	1.0	6.0	14.0
07	88.0	2.0	0.0	932.0
08	111.0	7.0	3.0	901.0
09	74.0	54.0	6.0	888.0
10	329.0	77.0	13.0	603.0
11	85.0	21.0	62.0	854.0
12	797.0	2.0	218.0	5.0
13	103.0	23.0	809.0	87.0
14	344.0	457.0	89.0	132.0
15	315.0	296.0	109.0	302.0

PFM

	A	C	G	T
01	0.254	0.146	0.383	0.217
02	0.308	0.052	0.309	0.331
03	0.105	0.058	0.517	0.321
04	0.032	0.798	0.041	0.128
05	0.004	0.017	0.0	0.979
06	0.979	0.001	0.006	0.014
07	0.086	0.002	0.0	0.912
08	0.109	0.007	0.003	0.882
09	0.072	0.053	0.006	0.869
10	0.322	0.075	0.013	0.59
11	0.083	0.021	0.061	0.836
12	0.78	0.002	0.213	0.005
13	0.101	0.023	0.792	0.085
14	0.337	0.447	0.087	0.129
15	0.308	0.29	0.107	0.295

PWM

	A	C	G	T
01	0.017	-0.534	0.423	-0.14
02	0.208	-1.548	0.211	0.278
03	-0.861	-1.444	0.722	0.248
04	-2.002	1.157	-1.772	-0.662
05	-3.804	-2.62	-5.0	1.361
06	1.361	-4.545	-3.505	-2.794
07	-1.053	-4.233	-5.0	1.289
08	-0.825	-3.383	-3.996	1.255
09	-1.223	-1.529	-3.505	1.241
10	0.251	-1.184	-2.86	0.855
11	-1.087	-2.426	-1.395	1.202
12	1.133	-4.233	-0.158	-3.643
13	-0.899	-2.342	1.148	-1.064
14	0.296	0.578	-1.042	-0.654
15	0.208	0.146	-0.843	0.166

Standard thresholds

P-value	Threshold
0.001	3.40361
0.0005	4.53651
0.0001	6.86566