| Motif | MEF2C.H12RSNP.1.SM.B |
| Gene (human) | MEF2C (GeneCards) |
| Gene synonyms (human) | |
| Gene (mouse) | Mef2c |
| Gene synonyms (mouse) | |
| LOGO |  |
| LOGO (reverse complement) |  |
| Motif subtype | 1 |
| Quality | B |
| Motif | MEF2C.H12RSNP.1.SM.B |
| Gene (human) | MEF2C (GeneCards) |
| Gene synonyms (human) | |
| Gene (mouse) | Mef2c |
| Gene synonyms (mouse) | |
| LOGO | |
| LOGO (reverse complement) | |
| Motif subtype | 1 |
| Quality | B |
| Motif length | 19 |
| Consensus | ndddCCMdATTAGGWWvbn |
| GC content | 41.82% |
| Information content (bits; total / per base) | 15.104 / 0.795 |
| Data sources | HT-SELEX + Methyl-HT-SELEX |
| Aligned words | 364 |
| ChIP-Seq benchmarking | Num. of experiments (peaksets) | auROC, median | auROC, best | auPRC, median | auPRC, best | pseudo-auROC, median | pseudo-auROC, best | pseudo-log-auROC, median | pseudo-log-auROC, best | Centrality, median | Centrality, best |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Human | 2 (12) | 0.615 | 0.68 | 0.49 | 0.505 | 0.528 | 0.593 | 1.252 | 1.432 | 16.033 | 48.921 |
| Mouse | 12 (78) | 0.696 | 0.751 | 0.525 | 0.604 | 0.595 | 0.629 | 1.398 | 1.64 | 33.041 | 196.237 |
| HT-SELEX benchmarking | auROC10 | auPRC10 | auROC25 | auPRC25 | auROC50 | auPRC50 | |
|---|---|---|---|---|---|---|---|
| Overall, 2 experiments | median | 0.971 | 0.959 | 0.905 | 0.887 | 0.755 | 0.765 |
| best | 0.973 | 0.961 | 0.912 | 0.893 | 0.768 | 0.774 | |
| Methyl HT-SELEX, 1 experiments | median | 0.97 | 0.956 | 0.898 | 0.88 | 0.742 | 0.755 |
| best | 0.97 | 0.956 | 0.898 | 0.88 | 0.742 | 0.755 | |
| Non-Methyl HT-SELEX, 1 experiments | median | 0.973 | 0.961 | 0.912 | 0.893 | 0.768 | 0.774 |
| best | 0.973 | 0.961 | 0.912 | 0.893 | 0.768 | 0.774 | |
| rSNP benchmarking, SNP-SELEX | auROC | auPRC | Pearson r | Kendall tau |
|---|---|---|---|---|
| batch 1 | 0.991 | 0.452 | 0.84 | 0.418 |
| batch 2 | 0.59 | 0.07 | 0.347 | 0.237 |
| TF superclass | alpha-Helices exposed by beta-structures {5} (TFClass) |
| TF class | MADS box factors {5.1} (TFClass) |
| TF family | Regulators of differentiation {5.1.1} (TFClass) |
| TF subfamily | MEF2 {5.1.1.1} (TFClass) |
| TFClass ID | TFClass: 5.1.1.1.3 |
| HGNC | HGNC:6996 |
| MGI | MGI:99458 |
| EntrezGene (human) | GeneID:4208 (SSTAR profile) |
| EntrezGene (mouse) | GeneID:17260 (SSTAR profile) |
| UniProt ID (human) | MEF2C_HUMAN |
| UniProt ID (mouse) | MEF2C_MOUSE |
| UniProt AC (human) | Q06413 (TFClass) |
| UniProt AC (mouse) | Q8CFN5 (TFClass) |
| GRECO-DB-TF | yes |
| ChIP-Seq | 2 human, 12 mouse |
| HT-SELEX | 1 |
| Methyl-HT-SELEX | 1 |
| PCM | MEF2C.H12RSNP.1.SM.B.pcm |
| PWM | MEF2C.H12RSNP.1.SM.B.pwm |
| PFM | MEF2C.H12RSNP.1.SM.B.pfm |
| Alignment | MEF2C.H12RSNP.1.SM.B.words.tsv |
| Threshold to P-value map | MEF2C.H12RSNP.1.SM.B.thr |
| Motif in other formats | |
| JASPAR format | MEF2C.H12RSNP.1.SM.B_jaspar_format.txt |
| MEME format | MEF2C.H12RSNP.1.SM.B_meme_format.meme |
| Transfac format | MEF2C.H12RSNP.1.SM.B_transfac_format.txt |
| Homer format | |
| A | C | G | T | |
|---|---|---|---|---|
| 01 | 79.5 | 73.5 | 107.5 | 103.5 |
| 02 | 67.25 | 56.25 | 133.25 | 107.25 |
| 03 | 66.0 | 56.0 | 76.0 | 166.0 |
| 04 | 66.0 | 27.0 | 115.0 | 156.0 |
| 05 | 49.0 | 307.0 | 4.0 | 4.0 |
| 06 | 0.0 | 297.0 | 0.0 | 67.0 |
| 07 | 205.0 | 84.0 | 18.0 | 57.0 |
| 08 | 192.0 | 23.0 | 62.0 | 87.0 |
| 09 | 301.0 | 0.0 | 1.0 | 62.0 |
| 10 | 0.0 | 0.0 | 0.0 | 364.0 |
| 11 | 18.0 | 0.0 | 0.0 | 346.0 |
| 12 | 184.0 | 0.0 | 0.0 | 180.0 |
| 13 | 22.0 | 0.0 | 342.0 | 0.0 |
| 14 | 0.0 | 0.0 | 364.0 | 0.0 |
| 15 | 264.0 | 28.0 | 32.0 | 40.0 |
| 16 | 238.0 | 39.0 | 17.0 | 70.0 |
| 17 | 139.0 | 108.0 | 61.0 | 56.0 |
| 18 | 43.0 | 159.0 | 108.0 | 54.0 |
| 19 | 87.5 | 84.5 | 109.5 | 82.5 |
| A | C | G | T | |
|---|---|---|---|---|
| 01 | 0.218 | 0.202 | 0.295 | 0.284 |
| 02 | 0.185 | 0.155 | 0.366 | 0.295 |
| 03 | 0.181 | 0.154 | 0.209 | 0.456 |
| 04 | 0.181 | 0.074 | 0.316 | 0.429 |
| 05 | 0.135 | 0.843 | 0.011 | 0.011 |
| 06 | 0.0 | 0.816 | 0.0 | 0.184 |
| 07 | 0.563 | 0.231 | 0.049 | 0.157 |
| 08 | 0.527 | 0.063 | 0.17 | 0.239 |
| 09 | 0.827 | 0.0 | 0.003 | 0.17 |
| 10 | 0.0 | 0.0 | 0.0 | 1.0 |
| 11 | 0.049 | 0.0 | 0.0 | 0.951 |
| 12 | 0.505 | 0.0 | 0.0 | 0.495 |
| 13 | 0.06 | 0.0 | 0.94 | 0.0 |
| 14 | 0.0 | 0.0 | 1.0 | 0.0 |
| 15 | 0.725 | 0.077 | 0.088 | 0.11 |
| 16 | 0.654 | 0.107 | 0.047 | 0.192 |
| 17 | 0.382 | 0.297 | 0.168 | 0.154 |
| 18 | 0.118 | 0.437 | 0.297 | 0.148 |
| 19 | 0.24 | 0.232 | 0.301 | 0.227 |
| A | C | G | T | |
|---|---|---|---|---|
| 01 | -0.133 | -0.21 | 0.164 | 0.127 |
| 02 | -0.297 | -0.471 | 0.376 | 0.162 |
| 03 | -0.315 | -0.476 | -0.177 | 0.594 |
| 04 | -0.315 | -1.178 | 0.231 | 0.532 |
| 05 | -0.605 | 1.205 | -2.827 | -2.827 |
| 06 | -4.139 | 1.172 | -4.139 | -0.3 |
| 07 | 0.803 | -0.079 | -1.558 | -0.458 |
| 08 | 0.738 | -1.329 | -0.376 | -0.044 |
| 09 | 1.185 | -4.139 | -3.621 | -0.376 |
| 10 | -4.139 | -4.139 | -4.139 | 1.374 |
| 11 | -1.558 | -4.139 | -4.139 | 1.324 |
| 12 | 0.696 | -4.139 | -4.139 | 0.674 |
| 13 | -1.371 | -4.139 | 1.312 | -4.139 |
| 14 | -4.139 | -4.139 | 1.374 | -4.139 |
| 15 | 1.055 | -1.143 | -1.016 | -0.802 |
| 16 | 0.952 | -0.826 | -1.611 | -0.258 |
| 17 | 0.418 | 0.169 | -0.392 | -0.476 |
| 18 | -0.732 | 0.551 | 0.169 | -0.511 |
| 19 | -0.039 | -0.073 | 0.182 | -0.096 |
| P-value | Threshold |
|---|---|
| 0.001 | 2.86576 |
| 0.0005 | 4.11576 |
| 0.0001 | 6.70821 |