MEF2C.H12INVIVO.0.P.B motif - HOmo sapiens COmprehensive MOdel COllection

Motif	MEF2C.H12INVIVO.0.P.B
Gene (human)	MEF2C (GeneCards)
Gene synonyms (human)
Gene (mouse)	Mef2c
Gene synonyms (mouse)
LOGO
LOGO (reverse complement)
Motif subtype	0
Quality	B

Motif length	14
Consensus	dKYTATTTWWRRhh
GC content	30.87%
Information content (bits; total / per base)	12.414 / 0.887
Data sources	ChIP-Seq
Aligned words	991

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Human	2 (12)	0.755	0.889	0.662	0.811	0.828	0.937	3.19	4.089	154.912	277.398
Mouse	12 (78)	0.819	0.935	0.73	0.896	0.855	0.94	3.372	4.359	184.611	342.886

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 2 experiments	median	0.795	0.75	0.687	0.665	0.595	0.601
Overall, 2 experiments	best	0.8	0.754	0.694	0.669	0.602	0.605
Methyl HT-SELEX, 1 experiments	median	0.79	0.746	0.68	0.66	0.589	0.597
Methyl HT-SELEX, 1 experiments	best	0.79	0.746	0.68	0.66	0.589	0.597
Non-Methyl HT-SELEX, 1 experiments	median	0.8	0.754	0.694	0.669	0.602	0.605
Non-Methyl HT-SELEX, 1 experiments	best	0.8	0.754	0.694	0.669	0.602	0.605

rSNP benchmarking, SNP-SELEX	auROC	auPRC	Pearson r	Kendall tau
batch 1	0.848	0.033	0.814	0.636
batch 2	0.503	0.016	0.252	0.113

TF superclass	alpha-Helices exposed by beta-structures {5} (TFClass)
TF class	MADS box factors {5.1} (TFClass)
TF family	Regulators of differentiation {5.1.1} (TFClass)
TF subfamily	MEF2 {5.1.1.1} (TFClass)
TFClass ID	TFClass: 5.1.1.1.3
HGNC	HGNC:6996
MGI	MGI:99458
EntrezGene (human)	GeneID:4208 (SSTAR profile)
EntrezGene (mouse)	GeneID:17260 (SSTAR profile)
UniProt ID (human)	MEF2C_HUMAN
UniProt ID (mouse)	MEF2C_MOUSE
UniProt AC (human)	Q06413 (TFClass)
UniProt AC (mouse)	Q8CFN5 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	2 human, 12 mouse
HT-SELEX	1
Methyl-HT-SELEX	1

PCM	MEF2C.H12INVIVO.0.P.B.pcm
PWM	MEF2C.H12INVIVO.0.P.B.pwm
PFM	MEF2C.H12INVIVO.0.P.B.pfm
Alignment	MEF2C.H12INVIVO.0.P.B.words.tsv
Threshold to P-value map	MEF2C.H12INVIVO.0.P.B.thr
Motif in other formats
JASPAR format	MEF2C.H12INVIVO.0.P.B_jaspar_format.txt
MEME format	MEF2C.H12INVIVO.0.P.B_meme_format.meme
Transfac format	MEF2C.H12INVIVO.0.P.B_transfac_format.txt
Homer format	MEF2C.H12INVIVO.0.P.B_homer_format_0.001.txt MEF2C.H12INVIVO.0.P.B_homer_format_0.0005.txt MEF2C.H12INVIVO.0.P.B_homer_format_0.0001.txt

PCM

	A	C	G	T
01	252.0	79.0	352.0	308.0
02	68.0	74.0	490.0	359.0
03	47.0	734.0	49.0	161.0
04	5.0	43.0	7.0	936.0
05	943.0	12.0	14.0	22.0
06	56.0	13.0	7.0	915.0
07	70.0	6.0	10.0	905.0
08	51.0	75.0	2.0	863.0
09	245.0	132.0	23.0	591.0
10	123.0	32.0	95.0	741.0
11	606.0	5.0	363.0	17.0
12	114.0	39.0	739.0	99.0
13	371.0	397.0	106.0	117.0
14	251.0	260.0	125.0	355.0

PFM

	A	C	G	T
01	0.254	0.08	0.355	0.311
02	0.069	0.075	0.494	0.362
03	0.047	0.741	0.049	0.162
04	0.005	0.043	0.007	0.945
05	0.952	0.012	0.014	0.022
06	0.057	0.013	0.007	0.923
07	0.071	0.006	0.01	0.913
08	0.051	0.076	0.002	0.871
09	0.247	0.133	0.023	0.596
10	0.124	0.032	0.096	0.748
11	0.612	0.005	0.366	0.017
12	0.115	0.039	0.746	0.1
13	0.374	0.401	0.107	0.118
14	0.253	0.262	0.126	0.358

PWM

	A	C	G	T
01	0.017	-1.128	0.349	0.216
02	-1.275	-1.192	0.679	0.369
03	-1.633	1.081	-1.593	-0.427
04	-3.614	-1.719	-3.353	1.324
05	1.332	-2.9	-2.764	-2.353
06	-1.464	-2.83	-3.353	1.301
07	-1.247	-3.475	-3.058	1.29
08	-1.554	-1.179	-4.204	1.243
09	-0.011	-0.624	-2.312	0.865
10	-0.693	-2.001	-0.947	1.091
11	0.89	-3.614	0.38	-2.59
12	-0.768	-1.813	1.088	-0.907
13	0.401	0.469	-0.84	-0.743
14	0.013	0.048	-0.677	0.358

Standard thresholds

P-value	Threshold
0.001	4.05681
0.0005	5.04871
0.0001	7.09181