MotifMEF2C.H12INVITRO.1.SM.B
Gene (human)MEF2C
(GeneCards)
Gene synonyms (human)
Gene (mouse)Mef2c
Gene synonyms (mouse)
LOGO
LOGO (reverse complement)
Motif subtype1
Quality
B
Motif length17
ConsensusndMCvnATTWGGhWhvn
GC content42.36%
Information content (bits; total / per base)11.32 / 0.666
Data sourcesHT-SELEX + Methyl-HT-SELEX
Aligned words8733

ChIP-Seq benchmarking Num. of experiments (peaksets) auROC, median auROC, best auPRC, median auPRC, best pseudo-auROC, median pseudo-auROC, best pseudo-log-auROC, median pseudo-log-auROC, best Centrality, median Centrality, best
Human 2 (12) 0.636 0.697 0.49 0.51 0.555 0.629 1.334 1.501 24.461 59.77
Mouse 12 (78) 0.716 0.738 0.542 0.594 0.627 0.651 1.503 1.633 38.916 184.854

HT-SELEX benchmarking auROC10 auPRC10 auROC25 auPRC25 auROC50 auPRC50
Overall, 2 experiments median 0.98 0.97 0.925 0.909 0.775 0.785
best 0.981 0.971 0.931 0.915 0.789 0.795
Methyl HT-SELEX, 1 experiments median 0.979 0.969 0.919 0.903 0.762 0.775
best 0.979 0.969 0.919 0.903 0.762 0.775
Non-Methyl HT-SELEX, 1 experiments median 0.981 0.971 0.931 0.915 0.789 0.795
best 0.981 0.971 0.931 0.915 0.789 0.795

rSNP benchmarking, SNP-SELEX auROC auPRC Pearson r Kendall tau
batch 1 0.961 0.397 0.881 0.636
batch 2 0.575 0.049 0.361 0.222
TF superclassalpha-Helices exposed by beta-structures {5} (TFClass)
TF classMADS box factors {5.1} (TFClass)
TF familyRegulators of differentiation {5.1.1} (TFClass)
TF subfamilyMEF2 {5.1.1.1} (TFClass)
TFClass IDTFClass: 5.1.1.1.3
HGNCHGNC:6996
MGIMGI:99458
EntrezGene (human)GeneID:4208
(SSTAR profile)
EntrezGene (mouse)GeneID:17260
(SSTAR profile)
UniProt ID (human)MEF2C_HUMAN
UniProt ID (mouse)MEF2C_MOUSE
UniProt AC (human)Q06413
(TFClass)
UniProt AC (mouse)Q8CFN5
(TFClass)
GRECO-DB-TF
yes
ChIP-Seq 2 human, 12 mouse
HT-SELEX 1
Methyl-HT-SELEX 1
PCM
ACGT
011985.51630.52285.52831.5
021083.25832.253174.253643.25
032307.05712.0250.0464.0
0495.06638.074.01926.0
053209.02672.01608.01244.0
063248.01367.02180.01938.0
076662.033.0161.01877.0
08509.03.021.08200.0
091967.015.037.06714.0
102725.037.086.05885.0
111624.01.07107.01.0
125.013.08648.067.0
134125.01652.0975.01981.0
145413.0859.0796.01665.0
153400.02828.01133.01372.0
161629.753745.751958.751398.75
172543.251802.252548.251839.25
PFM
ACGT
010.2270.1870.2620.324
020.1240.0950.3630.417
030.2640.6540.0290.053
040.0110.760.0080.221
050.3670.3060.1840.142
060.3720.1570.250.222
070.7630.0040.0180.215
080.0580.00.0020.939
090.2250.0020.0040.769
100.3120.0040.010.674
110.1860.00.8140.0
120.0010.0010.990.008
130.4720.1890.1120.227
140.620.0980.0910.191
150.3890.3240.130.157
160.1870.4290.2240.16
170.2910.2060.2920.211
PWM
ACGT
01-0.095-0.2920.0460.26
02-0.7-0.9630.3740.512
030.0550.961-2.159-1.545
04-3.1121.111-3.355-0.125
050.3850.202-0.305-0.562
060.397-0.468-0.001-0.119
071.115-4.127-2.594-0.151
08-1.453-6.028-4.5421.323
09-0.104-4.841-4.0191.123
100.221-4.019-3.2090.991
11-0.296-6.5051.18-6.505
12-5.706-4.9641.376-3.452
130.636-0.278-0.805-0.097
140.907-0.931-1.007-0.271
150.4430.259-0.655-0.464
16-0.2920.539-0.108-0.445
170.152-0.1920.154-0.171
Standard thresholds
P-value Threshold
0.001 4.34856
0.0005 5.42451
0.0001 7.42271