MEF2C.H12CORE.0.P.B motif - HOmo sapiens COmprehensive MOdel COllection

Motif	MEF2C.H12CORE.0.P.B
Gene (human)	MEF2C (GeneCards)
Gene synonyms (human)
Gene (mouse)	Mef2c
Gene synonyms (mouse)
LOGO
LOGO (reverse complement)
Motif subtype	0
Quality	B

Motif length	14
Consensus	ndbYTAWTTYWGKv
GC content	35.61%
Information content (bits; total / per base)	10.067 / 0.719
Data sources	ChIP-Seq
Aligned words	848

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Human	2 (12)	0.751	0.858	0.652	0.768	0.779	0.887	2.719	3.392	126.926	248.523
Mouse	12 (78)	0.834	0.899	0.755	0.833	0.839	0.893	3.125	3.53	163.914	426.114

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 2 experiments	median	0.906	0.868	0.806	0.776	0.674	0.679
Overall, 2 experiments	best	0.909	0.872	0.812	0.781	0.683	0.685
Methyl HT-SELEX, 1 experiments	median	0.903	0.865	0.799	0.77	0.665	0.673
Methyl HT-SELEX, 1 experiments	best	0.903	0.865	0.799	0.77	0.665	0.673
Non-Methyl HT-SELEX, 1 experiments	median	0.909	0.872	0.812	0.781	0.683	0.685
Non-Methyl HT-SELEX, 1 experiments	best	0.909	0.872	0.812	0.781	0.683	0.685

rSNP benchmarking, SNP-SELEX	auROC	auPRC	Pearson r	Kendall tau
batch 1	0.801	0.136	0.852	0.636
batch 2	0.582	0.024	0.356	0.21

TF superclass	alpha-Helices exposed by beta-structures {5} (TFClass)
TF class	MADS box factors {5.1} (TFClass)
TF family	Regulators of differentiation {5.1.1} (TFClass)
TF subfamily	MEF2 {5.1.1.1} (TFClass)
TFClass ID	TFClass: 5.1.1.1.3
HGNC	HGNC:6996
MGI	MGI:99458
EntrezGene (human)	GeneID:4208 (SSTAR profile)
EntrezGene (mouse)	GeneID:17260 (SSTAR profile)
UniProt ID (human)	MEF2C_HUMAN
UniProt ID (mouse)	MEF2C_MOUSE
UniProt AC (human)	Q06413 (TFClass)
UniProt AC (mouse)	Q8CFN5 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	2 human, 12 mouse
HT-SELEX	1
Methyl-HT-SELEX	1

PCM	MEF2C.H12CORE.0.P.B.pcm
PWM	MEF2C.H12CORE.0.P.B.pwm
PFM	MEF2C.H12CORE.0.P.B.pfm
Alignment	MEF2C.H12CORE.0.P.B.words.tsv
Threshold to P-value map	MEF2C.H12CORE.0.P.B.thr
Motif in other formats
JASPAR format	MEF2C.H12CORE.0.P.B_jaspar_format.txt
MEME format	MEF2C.H12CORE.0.P.B_meme_format.meme
Transfac format	MEF2C.H12CORE.0.P.B_transfac_format.txt
Homer format	MEF2C.H12CORE.0.P.B_homer_format_0.001.txt MEF2C.H12CORE.0.P.B_homer_format_0.0005.txt MEF2C.H12CORE.0.P.B_homer_format_0.0001.txt

PCM

	A	C	G	T
01	233.0	123.0	205.0	287.0
02	236.0	61.0	190.0	361.0
03	88.0	95.0	292.0	373.0
04	33.0	632.0	58.0	125.0
05	6.0	148.0	8.0	686.0
06	704.0	48.0	37.0	59.0
07	128.0	47.0	14.0	659.0
08	133.0	13.0	27.0	675.0
09	38.0	79.0	15.0	716.0
10	119.0	216.0	33.0	480.0
11	224.0	43.0	84.0	497.0
12	117.0	6.0	710.0	15.0
13	64.0	50.0	630.0	104.0
14	396.0	259.0	105.0	88.0

PFM

	A	C	G	T
01	0.275	0.145	0.242	0.338
02	0.278	0.072	0.224	0.426
03	0.104	0.112	0.344	0.44
04	0.039	0.745	0.068	0.147
05	0.007	0.175	0.009	0.809
06	0.83	0.057	0.044	0.07
07	0.151	0.055	0.017	0.777
08	0.157	0.015	0.032	0.796
09	0.045	0.093	0.018	0.844
10	0.14	0.255	0.039	0.566
11	0.264	0.051	0.099	0.586
12	0.138	0.007	0.837	0.018
13	0.075	0.059	0.743	0.123
14	0.467	0.305	0.124	0.104

PWM

	A	C	G	T
01	0.094	-0.539	-0.033	0.301
02	0.106	-1.226	-0.109	0.529
03	-0.868	-0.793	0.318	0.562
04	-1.818	1.087	-1.275	-0.523
05	-3.325	-0.356	-3.094	1.169
06	1.195	-1.459	-1.709	-1.259
07	-0.499	-1.479	-2.612	1.129
08	-0.462	-2.678	-2.008	1.153
09	-1.684	-0.974	-2.55	1.212
10	-0.571	0.019	-1.818	0.813
11	0.055	-1.565	-0.914	0.847
12	-0.588	-3.325	1.203	-2.55
13	-1.18	-1.419	1.084	-0.704
14	0.621	0.199	-0.695	-0.868

Standard thresholds

P-value	Threshold
0.001	4.68451
0.0005	5.48691
0.0001	7.15611