MEF2B.H12RSNP.0.PS.A motif - HOmo sapiens COmprehensive MOdel COllection

Motif	MEF2B.H12RSNP.0.PS.A
Gene (human)	MEF2B (GeneCards)
Gene synonyms (human)	XMEF2
Gene (mouse)	Mef2b
Gene synonyms (mouse)
LOGO
LOGO (reverse complement)
Motif subtype	0
Quality	A

Motif length	15
Consensus	dbKbCTWTTTYWRKn
GC content	36.94%
Information content (bits; total / per base)	11.083 / 0.739
Data sources	ChIP-Seq + HT-SELEX
Aligned words	1000

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Human	16 (100)	0.71	0.792	0.558	0.652	0.79	0.845	2.523	3.057	97.548	291.301

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 3 experiments	median	0.894	0.849	0.829	0.784	0.742	0.713
Overall, 3 experiments	best	0.936	0.904	0.883	0.845	0.795	0.768
Methyl HT-SELEX, 1 experiments	median	0.936	0.904	0.883	0.845	0.795	0.768
Methyl HT-SELEX, 1 experiments	best	0.936	0.904	0.883	0.845	0.795	0.768
Non-Methyl HT-SELEX, 2 experiments	median	0.717	0.704	0.667	0.654	0.618	0.611
Non-Methyl HT-SELEX, 2 experiments	best	0.894	0.849	0.829	0.784	0.742	0.713

rSNP benchmarking, ADASTRA	odds-ratio	-log-Fisher's P	Pearson r	Kendall tau
#	1.955	2.11	0.169	0.066

rSNP benchmarking, SNP-SELEX	auROC	auPRC	Pearson r	Kendall tau
batch 1	0.74	0.123	0.312	0.135
batch 2	0.73	0.141	0.542	0.38

TF superclass	alpha-Helices exposed by beta-structures {5} (TFClass)
TF class	MADS box factors {5.1} (TFClass)
TF family	Regulators of differentiation {5.1.1} (TFClass)
TF subfamily	MEF2 {5.1.1.1} (TFClass)
TFClass ID	TFClass: 5.1.1.1.2
HGNC	HGNC:6995
MGI	MGI:104526
EntrezGene (human)	GeneID:100271849 (SSTAR profile) GeneID:4207 (SSTAR profile)
EntrezGene (mouse)
UniProt ID (human)	MEF2B_HUMAN
UniProt ID (mouse)	MEF2B_MOUSE
UniProt AC (human)	Q02080 (TFClass)
UniProt AC (mouse)	O55087 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	16 human, 0 mouse
HT-SELEX	2
Methyl-HT-SELEX	1

PCM	MEF2B.H12RSNP.0.PS.A.pcm
PWM	MEF2B.H12RSNP.0.PS.A.pwm
PFM	MEF2B.H12RSNP.0.PS.A.pfm
Alignment	MEF2B.H12RSNP.0.PS.A.words.tsv
Threshold to P-value map	MEF2B.H12RSNP.0.PS.A.thr
Motif in other formats
JASPAR format	MEF2B.H12RSNP.0.PS.A_jaspar_format.txt
MEME format	MEF2B.H12RSNP.0.PS.A_meme_format.meme
Transfac format	MEF2B.H12RSNP.0.PS.A_transfac_format.txt
Homer format	MEF2B.H12RSNP.0.PS.A_homer_format_0.001.txt MEF2B.H12RSNP.0.PS.A_homer_format_0.0005.txt MEF2B.H12RSNP.0.PS.A_homer_format_0.0001.txt

PCM

	A	C	G	T
01	168.0	148.0	408.0	276.0
02	115.0	142.0	212.0	531.0
03	117.0	36.0	184.0	663.0
04	54.0	126.0	344.0	476.0
05	12.0	845.0	19.0	124.0
06	6.0	277.0	2.0	715.0
07	626.0	111.0	87.0	176.0
08	51.0	73.0	15.0	861.0
09	72.0	12.0	9.0	907.0
10	7.0	75.0	6.0	912.0
11	48.0	227.0	94.0	631.0
12	160.0	33.0	134.0	673.0
13	255.0	4.0	707.0	34.0
14	82.0	80.0	612.0	226.0
15	267.0	366.0	153.0	214.0

PFM

	A	C	G	T
01	0.168	0.148	0.408	0.276
02	0.115	0.142	0.212	0.531
03	0.117	0.036	0.184	0.663
04	0.054	0.126	0.344	0.476
05	0.012	0.845	0.019	0.124
06	0.006	0.277	0.002	0.715
07	0.626	0.111	0.087	0.176
08	0.051	0.073	0.015	0.861
09	0.072	0.012	0.009	0.907
10	0.007	0.075	0.006	0.912
11	0.048	0.227	0.094	0.631
12	0.16	0.033	0.134	0.673
13	0.255	0.004	0.707	0.034
14	0.082	0.08	0.612	0.226
15	0.267	0.366	0.153	0.214

PWM

	A	C	G	T
01	-0.394	-0.52	0.487	0.098
02	-0.769	-0.56	-0.164	0.75
03	-0.752	-1.898	-0.304	0.971
04	-1.508	-0.678	0.317	0.641
05	-2.909	1.213	-2.497	-0.694
06	-3.484	0.102	-4.213	1.046
07	0.914	-0.803	-1.043	-0.348
08	-1.563	-1.215	-2.711	1.232
09	-1.228	-2.909	-3.156	1.284
10	-3.362	-1.188	-3.484	1.289
11	-1.622	-0.096	-0.967	0.922
12	-0.442	-1.981	-0.618	0.986
13	0.02	-3.783	1.035	-1.952
14	-1.101	-1.125	0.891	-0.1
15	0.065	0.379	-0.487	-0.154

Standard thresholds

P-value	Threshold
0.001	4.49236
0.0005	5.37516
0.0001	7.18966