MEF2B.H12CORE.0.PS.A motif - HOmo sapiens COmprehensive MOdel COllection

Motif	MEF2B.H12CORE.0.PS.A
Gene (human)	MEF2B (GeneCards)
Gene synonyms (human)	XMEF2
Gene (mouse)	Mef2b
Gene synonyms (mouse)
LOGO
LOGO (reverse complement)
Motif subtype	0
Quality	A

Motif length	14
Consensus	ddddCYhYWThnRd
GC content	37.89%
Information content (bits; total / per base)	7.796 / 0.557
Data sources	ChIP-Seq + HT-SELEX
Aligned words	930

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Human	16 (100)	0.726	0.805	0.581	0.682	0.8	0.849	2.548	3.111	113.055	322.745

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 3 experiments	median	0.933	0.901	0.877	0.838	0.787	0.76
Overall, 3 experiments	best	0.96	0.938	0.915	0.886	0.823	0.801
Methyl HT-SELEX, 1 experiments	median	0.96	0.938	0.915	0.886	0.823	0.801
Methyl HT-SELEX, 1 experiments	best	0.96	0.938	0.915	0.886	0.823	0.801
Non-Methyl HT-SELEX, 2 experiments	median	0.735	0.733	0.688	0.681	0.639	0.634
Non-Methyl HT-SELEX, 2 experiments	best	0.933	0.901	0.877	0.838	0.787	0.76

rSNP benchmarking, ADASTRA	odds-ratio	-log-Fisher's P	Pearson r	Kendall tau
#	1.825	1.802	0.173	0.077

rSNP benchmarking, SNP-SELEX	auROC	auPRC	Pearson r	Kendall tau
batch 1	0.662	0.111	0.354	0.193
batch 2	0.754	0.181	0.556	0.396

TF superclass	alpha-Helices exposed by beta-structures {5} (TFClass)
TF class	MADS box factors {5.1} (TFClass)
TF family	Regulators of differentiation {5.1.1} (TFClass)
TF subfamily	MEF2 {5.1.1.1} (TFClass)
TFClass ID	TFClass: 5.1.1.1.2
HGNC	HGNC:6995
MGI	MGI:104526
EntrezGene (human)	GeneID:100271849 (SSTAR profile) GeneID:4207 (SSTAR profile)
EntrezGene (mouse)
UniProt ID (human)	MEF2B_HUMAN
UniProt ID (mouse)	MEF2B_MOUSE
UniProt AC (human)	Q02080 (TFClass)
UniProt AC (mouse)	O55087 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	16 human, 0 mouse
HT-SELEX	2
Methyl-HT-SELEX	1

PCM	MEF2B.H12CORE.0.PS.A.pcm
PWM	MEF2B.H12CORE.0.PS.A.pwm
PFM	MEF2B.H12CORE.0.PS.A.pfm
Alignment	MEF2B.H12CORE.0.PS.A.words.tsv
Threshold to P-value map	MEF2B.H12CORE.0.PS.A.thr
Motif in other formats
JASPAR format	MEF2B.H12CORE.0.PS.A_jaspar_format.txt
MEME format	MEF2B.H12CORE.0.PS.A_meme_format.meme
Transfac format	MEF2B.H12CORE.0.PS.A_transfac_format.txt
Homer format	MEF2B.H12CORE.0.PS.A_homer_format_0.001.txt MEF2B.H12CORE.0.PS.A_homer_format_0.0005.txt MEF2B.H12CORE.0.PS.A_homer_format_0.0001.txt

PCM

	A	C	G	T
01	237.0	125.0	344.0	224.0
02	157.0	139.0	198.0	436.0
03	176.0	57.0	216.0	481.0
04	156.0	104.0	279.0	391.0
05	21.0	755.0	45.0	109.0
06	8.0	313.0	3.0	606.0
07	532.0	134.0	109.0	155.0
08	90.0	130.0	31.0	679.0
09	133.0	79.0	15.0	703.0
10	19.0	92.0	31.0	788.0
11	116.0	182.0	102.0	530.0
12	153.0	79.0	153.0	545.0
13	291.0	12.0	561.0	66.0
14	111.0	101.0	544.0	174.0

PFM

	A	C	G	T
01	0.255	0.134	0.37	0.241
02	0.169	0.149	0.213	0.469
03	0.189	0.061	0.232	0.517
04	0.168	0.112	0.3	0.42
05	0.023	0.812	0.048	0.117
06	0.009	0.337	0.003	0.652
07	0.572	0.144	0.117	0.167
08	0.097	0.14	0.033	0.73
09	0.143	0.085	0.016	0.756
10	0.02	0.099	0.033	0.847
11	0.125	0.196	0.11	0.57
12	0.165	0.085	0.165	0.586
13	0.313	0.013	0.603	0.071
14	0.119	0.109	0.585	0.187

PWM

	A	C	G	T
01	0.019	-0.614	0.389	-0.037
02	-0.389	-0.51	-0.159	0.625
03	-0.276	-1.384	-0.073	0.723
04	-0.395	-0.796	0.181	0.517
05	-2.333	1.173	-1.612	-0.749
06	-3.183	0.295	-3.907	0.953
07	0.824	-0.546	-0.749	-0.402
08	-0.938	-0.576	-1.969	1.067
09	-0.553	-1.065	-2.64	1.102
10	-2.426	-0.916	-1.969	1.215
11	-0.688	-0.243	-0.815	0.82
12	-0.415	-1.065	-0.415	0.848
13	0.223	-2.838	0.877	-1.241
14	-0.731	-0.824	0.846	-0.287

Standard thresholds

P-value	Threshold
0.001	4.95641
0.0005	5.61686
0.0001	6.97426