MCR.H12CORE.0.S.B motif - HOmo sapiens COmprehensive MOdel COllection

Motif	MCR.H12CORE.0.S.B
Gene (human)	NR3C2 (GeneCards)
Gene synonyms (human)	MCR, MLR
Gene (mouse)	Nr3c2
Gene synonyms (mouse)	Mlr
LOGO
LOGO (reverse complement)
Motif subtype	0
Quality	B

Motif length	17
Consensus	nRGdACAhARTGThCYn
GC content	44.48%
Information content (bits; total / per base)	18.23 / 1.072
Data sources	HT-SELEX
Aligned words	9484

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 4 experiments	median	0.968	0.95	0.856	0.849	0.764	0.763
Overall, 4 experiments	best	0.982	0.978	0.962	0.945	0.91	0.889
Methyl HT-SELEX, 1 experiments	median	0.982	0.971	0.962	0.945	0.91	0.889
Methyl HT-SELEX, 1 experiments	best	0.982	0.971	0.962	0.945	0.91	0.889
Non-Methyl HT-SELEX, 3 experiments	median	0.958	0.929	0.78	0.8	0.649	0.681
Non-Methyl HT-SELEX, 3 experiments	best	0.979	0.978	0.931	0.898	0.88	0.845

TF superclass	Zinc-coordinating DNA-binding domains {2} (TFClass)
TF class	Nuclear receptors with C4 zinc fingers {2.1} (TFClass)
TF family	Steroid hormone receptors {2.1.1} (TFClass)
TF subfamily	GR-like (NR3C) {2.1.1.1} (TFClass)
TFClass ID	TFClass: 2.1.1.1.2
HGNC	HGNC:7979
MGI	MGI:99459
EntrezGene (human)	GeneID:4306 (SSTAR profile)
EntrezGene (mouse)
UniProt ID (human)	MCR_HUMAN
UniProt ID (mouse)	MCR_MOUSE
UniProt AC (human)	P08235 (TFClass)
UniProt AC (mouse)	Q8VII8 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	0 human, 0 mouse
HT-SELEX	3
Methyl-HT-SELEX	1

PCM	MCR.H12CORE.0.S.B.pcm
PWM	MCR.H12CORE.0.S.B.pwm
PFM	MCR.H12CORE.0.S.B.pfm
Alignment	MCR.H12CORE.0.S.B.words.tsv
Threshold to P-value map	MCR.H12CORE.0.S.B.thr
Motif in other formats
JASPAR format	MCR.H12CORE.0.S.B_jaspar_format.txt
MEME format	MCR.H12CORE.0.S.B_meme_format.meme
Transfac format	MCR.H12CORE.0.S.B_transfac_format.txt
Homer format	MCR.H12CORE.0.S.B_homer_format_0.001.txt MCR.H12CORE.0.S.B_homer_format_0.0005.txt MCR.H12CORE.0.S.B_homer_format_0.0001.txt

PCM

	A	C	G	T
01	2171.75	1677.75	3405.75	2228.75
02	3651.0	488.0	4604.0	741.0
03	82.0	20.0	9345.0	37.0
04	4812.0	553.0	1522.0	2597.0
05	9426.0	21.0	16.0	21.0
06	20.0	9425.0	17.0	22.0
07	8682.0	22.0	594.0	186.0
08	2119.0	3450.0	954.0	2961.0
09	6788.0	0.0	2696.0	0.0
10	6517.0	526.0	1415.0	1026.0
11	233.0	325.0	29.0	8897.0
12	26.0	7.0	9444.0	7.0
13	16.0	8.0	6.0	9454.0
14	2887.0	1630.0	345.0	4622.0
15	34.0	9370.0	14.0	66.0
16	848.75	4548.75	446.75	3639.75
17	2799.0	3050.0	1734.0	1901.0

PFM

	A	C	G	T
01	0.229	0.177	0.359	0.235
02	0.385	0.051	0.485	0.078
03	0.009	0.002	0.985	0.004
04	0.507	0.058	0.16	0.274
05	0.994	0.002	0.002	0.002
06	0.002	0.994	0.002	0.002
07	0.915	0.002	0.063	0.02
08	0.223	0.364	0.101	0.312
09	0.716	0.0	0.284	0.0
10	0.687	0.055	0.149	0.108
11	0.025	0.034	0.003	0.938
12	0.003	0.001	0.996	0.001
13	0.002	0.001	0.001	0.997
14	0.304	0.172	0.036	0.487
15	0.004	0.988	0.001	0.007
16	0.089	0.48	0.047	0.384
17	0.295	0.322	0.183	0.2

PWM

	A	C	G	T
01	-0.088	-0.345	0.362	-0.062
02	0.431	-1.577	0.663	-1.161
03	-3.338	-4.668	1.371	-4.101
04	0.707	-1.453	-0.443	0.091
05	1.379	-4.624	-4.866	-4.624
06	-4.668	1.379	-4.812	-4.582
07	1.297	-4.582	-1.381	-2.534
08	-0.112	0.375	-0.909	0.222
09	1.051	-6.944	0.128	-6.944
10	1.01	-1.502	-0.516	-0.836
11	-2.311	-1.981	-4.329	1.322
12	-4.43	-5.543	1.381	-5.543
13	-4.866	-5.441	-5.657	1.382
14	0.197	-0.374	-1.922	0.667
15	-4.181	1.373	-4.982	-3.548
16	-1.026	0.651	-1.665	0.428
17	0.166	0.252	-0.313	-0.221

Standard thresholds

P-value	Threshold
0.001	-0.71054
0.0005	0.96651
0.0001	4.52496