MAX.H12INVITRO.1.M.C motif - HOmo sapiens COmprehensive MOdel COllection

Motif	MAX.H12INVITRO.1.M.C
Gene (human)	MAX (GeneCards)
Gene synonyms (human)	BHLHD4
Gene (mouse)	Max
Gene synonyms (mouse)	Myn
LOGO
LOGO (reverse complement)
Motif subtype	1
Quality	C

Motif length	14
Consensus	nnvvCATGTGnbnn
GC content	50.09%
Information content (bits; total / per base)	10.862 / 0.776
Data sources	Methyl-HT-SELEX
Aligned words	9432

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Human	39 (261)	0.831	0.914	0.649	0.773	0.76	0.882	1.989	2.789	120.357	414.523
Mouse	6 (39)	0.809	0.884	0.629	0.726	0.756	0.852	2.198	2.569	146.036	352.215

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 6 experiments	median	0.982	0.967	0.978	0.961	0.948	0.93
Overall, 6 experiments	best	0.99	0.98	0.988	0.978	0.984	0.971
Methyl HT-SELEX, 1 experiments	median	0.977	0.96	0.965	0.944	0.938	0.913
Methyl HT-SELEX, 1 experiments	best	0.977	0.96	0.965	0.944	0.938	0.913
Non-Methyl HT-SELEX, 5 experiments	median	0.984	0.97	0.98	0.965	0.959	0.932
Non-Methyl HT-SELEX, 5 experiments	best	0.99	0.98	0.988	0.978	0.984	0.971

rSNP benchmarking, ADASTRA	odds-ratio	-log-Fisher's P	Pearson r	Kendall tau
#	3.576	6.461	0.235	0.157

TF superclass	Basic domains {1} (TFClass)
TF class	Basic helix-loop-helix factors (bHLH) {1.2} (TFClass)
TF family	bHLH-ZIP {1.2.6} (TFClass)
TF subfamily	MYC {1.2.6.5} (TFClass)
TFClass ID	TFClass: 1.2.6.5.5
HGNC	HGNC:6913
MGI	MGI:96921
EntrezGene (human)	GeneID:4149 (SSTAR profile)
EntrezGene (mouse)	GeneID:17187 (SSTAR profile)
UniProt ID (human)	MAX_HUMAN
UniProt ID (mouse)	MAX_MOUSE
UniProt AC (human)	P61244 (TFClass)
UniProt AC (mouse)	P28574 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	39 human, 6 mouse
HT-SELEX	5
Methyl-HT-SELEX	1

PCM	MAX.H12INVITRO.1.M.C.pcm
PWM	MAX.H12INVITRO.1.M.C.pwm
PFM	MAX.H12INVITRO.1.M.C.pfm
Alignment	MAX.H12INVITRO.1.M.C.words.tsv
Threshold to P-value map	MAX.H12INVITRO.1.M.C.thr
Motif in other formats
JASPAR format	MAX.H12INVITRO.1.M.C_jaspar_format.txt
MEME format	MAX.H12INVITRO.1.M.C_meme_format.meme
Transfac format	MAX.H12INVITRO.1.M.C_transfac_format.txt
Homer format	MAX.H12INVITRO.1.M.C_homer_format_0.001.txt MAX.H12INVITRO.1.M.C_homer_format_0.0005.txt MAX.H12INVITRO.1.M.C_homer_format_0.0001.txt

PCM

	A	C	G	T
01	2099.5	2169.5	2294.5	2868.5
02	2930.75	1475.75	2046.75	2978.75
03	4586.0	1627.0	1735.0	1484.0
04	2552.0	3591.0	2970.0	319.0
05	8.0	9421.0	2.0	1.0
06	9420.0	0.0	11.0	1.0
07	0.0	1515.0	0.0	7917.0
08	0.0	5.0	9427.0	0.0
09	83.0	1602.0	14.0	7733.0
10	9.0	44.0	8436.0	943.0
11	1932.0	3632.0	1843.0	2025.0
12	1276.0	2070.0	1813.0	4273.0
13	2463.5	2513.5	1388.5	3066.5
14	2729.0	2277.0	2221.0	2205.0

PFM

	A	C	G	T
01	0.223	0.23	0.243	0.304
02	0.311	0.156	0.217	0.316
03	0.486	0.172	0.184	0.157
04	0.271	0.381	0.315	0.034
05	0.001	0.999	0.0	0.0
06	0.999	0.0	0.001	0.0
07	0.0	0.161	0.0	0.839
08	0.0	0.001	0.999	0.0
09	0.009	0.17	0.001	0.82
10	0.001	0.005	0.894	0.1
11	0.205	0.385	0.195	0.215
12	0.135	0.219	0.192	0.453
13	0.261	0.266	0.147	0.325
14	0.289	0.241	0.235	0.234

PWM

	A	C	G	T
01	-0.116	-0.083	-0.027	0.196
02	0.217	-0.468	-0.141	0.233
03	0.665	-0.371	-0.306	-0.463
04	0.079	0.42	0.231	-1.994
05	-5.436	1.384	-6.311	-6.576
06	1.384	-6.939	-5.18	-6.576
07	-6.939	-0.442	-6.939	1.211
08	-6.939	-5.78	1.385	-6.939
09	-3.321	-0.386	-4.976	1.187
10	-5.343	-3.932	1.274	-0.915
11	-0.199	0.432	-0.246	-0.152
12	-0.613	-0.13	-0.263	0.594
13	0.044	0.064	-0.529	0.262
14	0.146	-0.035	-0.06	-0.067

Standard thresholds

P-value	Threshold
0.001	4.47141
0.0005	5.84516
0.0001	7.72496