MAX.H12INVITRO.0.PS.A motif - HOmo sapiens COmprehensive MOdel COllection

Motif	MAX.H12INVITRO.0.PS.A
Gene (human)	MAX (GeneCards)
Gene synonyms (human)	BHLHD4
Gene (mouse)	Max
Gene synonyms (mouse)	Myn
LOGO
LOGO (reverse complement)
Motif subtype	0
Quality	A

Motif length	11
Consensus	ndRbCACGTGn
GC content	57.06%
Information content (bits; total / per base)	11.629 / 1.057
Data sources	ChIP-Seq + HT-SELEX
Aligned words	9764

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Human	39 (261)	0.875	0.972	0.786	0.938	0.819	0.944	2.737	4.039	222.347	646.469
Mouse	6 (39)	0.858	0.937	0.756	0.899	0.804	0.906	2.599	3.77	187.337	518.056

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 6 experiments	median	0.994	0.989	0.99	0.984	0.967	0.96
Overall, 6 experiments	best	0.999	0.998	0.998	0.996	0.994	0.99
Methyl HT-SELEX, 1 experiments	median	0.946	0.912	0.923	0.882	0.894	0.848
Methyl HT-SELEX, 1 experiments	best	0.946	0.912	0.923	0.882	0.894	0.848
Non-Methyl HT-SELEX, 5 experiments	median	0.996	0.994	0.991	0.987	0.969	0.965
Non-Methyl HT-SELEX, 5 experiments	best	0.999	0.998	0.998	0.996	0.994	0.99

rSNP benchmarking, ADASTRA	odds-ratio	-log-Fisher's P	Pearson r	Kendall tau
#	20.94	20.862	0.312	0.256

TF superclass	Basic domains {1} (TFClass)
TF class	Basic helix-loop-helix factors (bHLH) {1.2} (TFClass)
TF family	bHLH-ZIP {1.2.6} (TFClass)
TF subfamily	MYC {1.2.6.5} (TFClass)
TFClass ID	TFClass: 1.2.6.5.5
HGNC	HGNC:6913
MGI	MGI:96921
EntrezGene (human)	GeneID:4149 (SSTAR profile)
EntrezGene (mouse)	GeneID:17187 (SSTAR profile)
UniProt ID (human)	MAX_HUMAN
UniProt ID (mouse)	MAX_MOUSE
UniProt AC (human)	P61244 (TFClass)
UniProt AC (mouse)	P28574 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	39 human, 6 mouse
HT-SELEX	5
Methyl-HT-SELEX	1

PCM	MAX.H12INVITRO.0.PS.A.pcm
PWM	MAX.H12INVITRO.0.PS.A.pwm
PFM	MAX.H12INVITRO.0.PS.A.pfm
Alignment	MAX.H12INVITRO.0.PS.A.words.tsv
Threshold to P-value map	MAX.H12INVITRO.0.PS.A.thr
Motif in other formats
JASPAR format	MAX.H12INVITRO.0.PS.A_jaspar_format.txt
MEME format	MAX.H12INVITRO.0.PS.A_meme_format.meme
Transfac format	MAX.H12INVITRO.0.PS.A_transfac_format.txt
Homer format	MAX.H12INVITRO.0.PS.A_homer_format_0.001.txt MAX.H12INVITRO.0.PS.A_homer_format_0.0005.txt MAX.H12INVITRO.0.PS.A_homer_format_0.0001.txt

PCM

	A	C	G	T
01	2500.0	1936.0	2509.0	2819.0
02	3490.5	974.5	2487.5	2811.5
03	5654.0	279.0	2809.0	1022.0
04	1001.0	3327.0	3347.0	2089.0
05	0.0	9764.0	0.0	0.0
06	9764.0	0.0	0.0	0.0
07	0.0	9502.0	0.0	262.0
08	6.0	0.0	9758.0	0.0
09	94.0	675.0	0.0	8995.0
10	86.5	97.5	8814.5	765.5
11	2312.5	2244.5	2762.5	2444.5

PFM

	A	C	G	T
01	0.256	0.198	0.257	0.289
02	0.357	0.1	0.255	0.288
03	0.579	0.029	0.288	0.105
04	0.103	0.341	0.343	0.214
05	0.0	1.0	0.0	0.0
06	1.0	0.0	0.0	0.0
07	0.0	0.973	0.0	0.027
08	0.001	0.0	0.999	0.0
09	0.01	0.069	0.0	0.921
10	0.009	0.01	0.903	0.078
11	0.237	0.23	0.283	0.25

PWM

	A	C	G	T
01	0.024	-0.232	0.027	0.144
02	0.357	-0.917	0.019	0.141
03	0.839	-2.162	0.14	-0.869
04	-0.89	0.309	0.315	-0.156
05	-6.97	1.386	-6.97	-6.97
06	1.386	-6.97	-6.97	-6.97
07	-6.97	1.358	-6.97	-2.224
08	-5.685	-6.97	1.385	-6.97
09	-3.234	-1.283	-6.97	1.304
10	-3.315	-3.198	1.283	-1.158
11	-0.054	-0.084	0.124	0.001

Standard thresholds

P-value	Threshold
0.001	3.79152
0.0005	5.15189
0.0001	7.795155