MAX.H12CORE.1.M.C motif - HOmo sapiens COmprehensive MOdel COllection

Motif	MAX.H12CORE.1.M.C
Gene (human)	MAX (GeneCards)
Gene synonyms (human)	BHLHD4
Gene (mouse)	Max
Gene synonyms (mouse)	Myn
LOGO
LOGO (reverse complement)
Motif subtype	1
Quality	C

Motif length	14
Consensus	nnvvCATGTGvbhn
GC content	48.7%
Information content (bits; total / per base)	12.384 / 0.885
Data sources	Methyl-HT-SELEX
Aligned words	6199

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Human	39 (261)	0.836	0.919	0.653	0.769	0.771	0.9	2.076	2.871	105.155	415.187
Mouse	6 (39)	0.814	0.886	0.626	0.717	0.765	0.868	2.263	2.674	136.167	332.658

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 6 experiments	median	0.981	0.963	0.978	0.96	0.948	0.929
Overall, 6 experiments	best	0.988	0.976	0.989	0.977	0.983	0.969
Methyl HT-SELEX, 1 experiments	median	0.974	0.956	0.964	0.941	0.936	0.91
Methyl HT-SELEX, 1 experiments	best	0.974	0.956	0.964	0.941	0.936	0.91
Non-Methyl HT-SELEX, 5 experiments	median	0.981	0.966	0.978	0.961	0.96	0.931
Non-Methyl HT-SELEX, 5 experiments	best	0.988	0.976	0.989	0.977	0.983	0.969

rSNP benchmarking, ADASTRA	odds-ratio	-log-Fisher's P	Pearson r	Kendall tau
#	4.178	7.511	0.237	0.155

TF superclass	Basic domains {1} (TFClass)
TF class	Basic helix-loop-helix factors (bHLH) {1.2} (TFClass)
TF family	bHLH-ZIP {1.2.6} (TFClass)
TF subfamily	MYC {1.2.6.5} (TFClass)
TFClass ID	TFClass: 1.2.6.5.5
HGNC	HGNC:6913
MGI	MGI:96921
EntrezGene (human)	GeneID:4149 (SSTAR profile)
EntrezGene (mouse)	GeneID:17187 (SSTAR profile)
UniProt ID (human)	MAX_HUMAN
UniProt ID (mouse)	MAX_MOUSE
UniProt AC (human)	P61244 (TFClass)
UniProt AC (mouse)	P28574 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	39 human, 6 mouse
HT-SELEX	5
Methyl-HT-SELEX	1

PCM	MAX.H12CORE.1.M.C.pcm
PWM	MAX.H12CORE.1.M.C.pwm
PFM	MAX.H12CORE.1.M.C.pfm
Alignment	MAX.H12CORE.1.M.C.words.tsv
Threshold to P-value map	MAX.H12CORE.1.M.C.thr
Motif in other formats
JASPAR format	MAX.H12CORE.1.M.C_jaspar_format.txt
MEME format	MAX.H12CORE.1.M.C_meme_format.meme
Transfac format	MAX.H12CORE.1.M.C_transfac_format.txt
Homer format	MAX.H12CORE.1.M.C_homer_format_0.001.txt MAX.H12CORE.1.M.C_homer_format_0.0005.txt MAX.H12CORE.1.M.C_homer_format_0.0001.txt

PCM

	A	C	G	T
01	1382.5	1384.5	1503.5	1928.5
02	2003.25	865.25	1321.25	2009.25
03	3284.0	1028.0	1031.0	856.0
04	1687.0	2416.0	1973.0	123.0
05	0.0	6199.0	0.0	0.0
06	6199.0	0.0	0.0	0.0
07	0.0	611.0	0.0	5588.0
08	0.0	0.0	6199.0	0.0
09	1.0	256.0	0.0	5942.0
10	0.0	1.0	6119.0	79.0
11	1248.0	2720.0	1183.0	1048.0
12	639.0	1223.0	941.0	3396.0
13	1605.5	1624.5	768.5	2200.5
14	1864.25	1435.25	1459.25	1440.25

PFM

	A	C	G	T
01	0.223	0.223	0.243	0.311
02	0.323	0.14	0.213	0.324
03	0.53	0.166	0.166	0.138
04	0.272	0.39	0.318	0.02
05	0.0	1.0	0.0	0.0
06	1.0	0.0	0.0	0.0
07	0.0	0.099	0.0	0.901
08	0.0	0.0	1.0	0.0
09	0.0	0.041	0.0	0.959
10	0.0	0.0	0.987	0.013
11	0.201	0.439	0.191	0.169
12	0.103	0.197	0.152	0.548
13	0.259	0.262	0.124	0.355
14	0.301	0.232	0.235	0.232

PWM

	A	C	G	T
01	-0.114	-0.113	-0.03	0.218
02	0.256	-0.582	-0.159	0.259
03	0.75	-0.41	-0.407	-0.592
04	0.085	0.444	0.241	-2.517
05	-6.567	1.385	-6.567	-6.567
06	1.385	-6.567	-6.567	-6.567
07	-6.567	-0.929	-6.567	1.282
08	-6.567	-6.567	1.385	-6.567
09	-6.189	-1.794	-6.567	1.343
10	-6.567	-6.189	1.372	-2.951
11	-0.216	0.562	-0.27	-0.391
12	-0.884	-0.236	-0.498	0.784
13	0.035	0.047	-0.7	0.35
14	0.185	-0.077	-0.06	-0.073

Standard thresholds

P-value	Threshold
0.001	2.39071
0.0005	4.61256
0.0001	7.730115