MAFF.H12RSNP.1.PSM.A motif - HOmo sapiens COmprehensive MOdel COllection

Motif	MAFF.H12RSNP.1.PSM.A
Gene (human)	MAFF (GeneCards)
Gene synonyms (human)
Gene (mouse)	Maff
Gene synonyms (mouse)
LOGO
LOGO (reverse complement)
Motif subtype	1
Quality	A

Motif length	10
Consensus	RASTCAGCAd
GC content	50.79%
Information content (bits; total / per base)	14.78 / 1.478
Data sources	ChIP-Seq + HT-SELEX + Methyl-HT-SELEX
Aligned words	699

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Human	2 (14)	0.945	0.961	0.894	0.92	0.906	0.929	3.771	3.97	723.323	880.114
Mouse	7 (48)	0.896	0.933	0.86	0.906	0.882	0.922	3.726	4.179	276.887	569.149

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 4 experiments	median	0.995	0.992	0.985	0.978	0.938	0.93
Overall, 4 experiments	best	0.997	0.996	0.994	0.99	0.986	0.981
Methyl HT-SELEX, 2 experiments	median	0.995	0.992	0.985	0.978	0.938	0.93
Methyl HT-SELEX, 2 experiments	best	0.996	0.992	0.989	0.983	0.972	0.962
Non-Methyl HT-SELEX, 2 experiments	median	0.76	0.765	0.748	0.752	0.742	0.743
Non-Methyl HT-SELEX, 2 experiments	best	0.997	0.996	0.994	0.99	0.986	0.981

rSNP benchmarking, SNP-SELEX	auROC	auPRC	Pearson r	Kendall tau
batch 2	0.734	0.701	0.734	0.541

TF superclass	Basic domains {1} (TFClass)
TF class	Basic leucine zipper factors (bZIP) {1.1} (TFClass)
TF family	Maf-related {1.1.3} (TFClass)
TF subfamily	Small MAF {1.1.3.2} (TFClass)
TFClass ID	TFClass: 1.1.3.2.1
HGNC	HGNC:6780
MGI	MGI:96910
EntrezGene (human)	GeneID:23764 (SSTAR profile)
EntrezGene (mouse)	GeneID:17133 (SSTAR profile)
UniProt ID (human)	MAFF_HUMAN
UniProt ID (mouse)	MAFF_MOUSE
UniProt AC (human)	Q9ULX9 (TFClass)
UniProt AC (mouse)	O54791 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	2 human, 7 mouse
HT-SELEX	2
Methyl-HT-SELEX	2

PCM	MAFF.H12RSNP.1.PSM.A.pcm
PWM	MAFF.H12RSNP.1.PSM.A.pwm
PFM	MAFF.H12RSNP.1.PSM.A.pfm
Alignment	MAFF.H12RSNP.1.PSM.A.words.tsv
Threshold to P-value map	MAFF.H12RSNP.1.PSM.A.thr
Motif in other formats
JASPAR format	MAFF.H12RSNP.1.PSM.A_jaspar_format.txt
MEME format	MAFF.H12RSNP.1.PSM.A_meme_format.meme
Transfac format	MAFF.H12RSNP.1.PSM.A_transfac_format.txt
Homer format	MAFF.H12RSNP.1.PSM.A_homer_format_0.001.txt MAFF.H12RSNP.1.PSM.A_homer_format_0.0005.txt MAFF.H12RSNP.1.PSM.A_homer_format_0.0001.txt

PCM

	A	C	G	T
01	67.0	30.0	537.0	65.0
02	642.0	7.0	12.0	38.0
03	40.0	237.0	409.0	13.0
04	2.0	0.0	0.0	697.0
05	4.0	695.0	0.0	0.0
06	699.0	0.0	0.0	0.0
07	1.0	0.0	687.0	11.0
08	0.0	699.0	0.0	0.0
09	681.0	0.0	7.0	11.0
10	300.0	76.0	154.0	169.0

PFM

	A	C	G	T
01	0.096	0.043	0.768	0.093
02	0.918	0.01	0.017	0.054
03	0.057	0.339	0.585	0.019
04	0.003	0.0	0.0	0.997
05	0.006	0.994	0.0	0.0
06	1.0	0.0	0.0	0.0
07	0.001	0.0	0.983	0.016
08	0.0	1.0	0.0	0.0
09	0.974	0.0	0.01	0.016
10	0.429	0.109	0.22	0.242

PWM

	A	C	G	T
01	-0.944	-1.718	1.116	-0.973
02	1.294	-3.017	-2.56	-1.493
03	-1.444	0.302	0.845	-2.489
04	-3.881	-4.68	-4.68	1.376
05	-3.443	1.374	-4.68	-4.68
06	1.379	-4.68	-4.68	-4.68
07	-4.203	-4.68	1.362	-2.636
08	-4.68	1.379	-4.68	-4.68
09	1.353	-4.68	-3.017	-2.636
10	0.537	-0.821	-0.125	-0.033

Standard thresholds

P-value	Threshold
0.001	2.34976
0.0005	3.662385
0.0001	6.42156