MAFF.H12INVITRO.0.PSM.A motif - HOmo sapiens COmprehensive MOdel COllection

Motif	MAFF.H12INVITRO.0.PSM.A
Gene (human)	MAFF (GeneCards)
Gene synonyms (human)
Gene (mouse)	Maff
Gene synonyms (mouse)
LOGO
LOGO (reverse complement)
Motif subtype	0
Quality	A

Motif length	18
Consensus	WGMWRWSTCAGCAdWWhh
GC content	42.18%
Information content (bits; total / per base)	18.603 / 1.034
Data sources	ChIP-Seq + HT-SELEX + Methyl-HT-SELEX
Aligned words	850

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Human	2 (14)	0.972	0.98	0.96	0.972	0.962	0.973	6.49	7.08	853.673	1017.921
Mouse	7 (48)	0.925	0.958	0.91	0.947	0.919	0.952	6.05	7.189	339.542	678.187

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 4 experiments	median	0.986	0.982	0.924	0.92	0.833	0.841
Overall, 4 experiments	best	1.0	0.999	0.999	0.998	0.993	0.991
Methyl HT-SELEX, 2 experiments	median	0.986	0.982	0.924	0.92	0.833	0.841
Methyl HT-SELEX, 2 experiments	best	0.999	0.998	0.994	0.992	0.965	0.959
Non-Methyl HT-SELEX, 2 experiments	median	0.781	0.785	0.764	0.767	0.752	0.755
Non-Methyl HT-SELEX, 2 experiments	best	1.0	0.999	0.999	0.998	0.993	0.991

rSNP benchmarking, SNP-SELEX	auROC	auPRC	Pearson r	Kendall tau
batch 2	0.796	0.703	0.753	0.537

TF superclass	Basic domains {1} (TFClass)
TF class	Basic leucine zipper factors (bZIP) {1.1} (TFClass)
TF family	Maf-related {1.1.3} (TFClass)
TF subfamily	Small MAF {1.1.3.2} (TFClass)
TFClass ID	TFClass: 1.1.3.2.1
HGNC	HGNC:6780
MGI	MGI:96910
EntrezGene (human)	GeneID:23764 (SSTAR profile)
EntrezGene (mouse)	GeneID:17133 (SSTAR profile)
UniProt ID (human)	MAFF_HUMAN
UniProt ID (mouse)	MAFF_MOUSE
UniProt AC (human)	Q9ULX9 (TFClass)
UniProt AC (mouse)	O54791 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	2 human, 7 mouse
HT-SELEX	2
Methyl-HT-SELEX	2

PCM	MAFF.H12INVITRO.0.PSM.A.pcm
PWM	MAFF.H12INVITRO.0.PSM.A.pwm
PFM	MAFF.H12INVITRO.0.PSM.A.pfm
Alignment	MAFF.H12INVITRO.0.PSM.A.words.tsv
Threshold to P-value map	MAFF.H12INVITRO.0.PSM.A.thr
Motif in other formats
JASPAR format	MAFF.H12INVITRO.0.PSM.A_jaspar_format.txt
MEME format	MAFF.H12INVITRO.0.PSM.A_meme_format.meme
Transfac format	MAFF.H12INVITRO.0.PSM.A_transfac_format.txt
Homer format	MAFF.H12INVITRO.0.PSM.A_homer_format_0.001.txt MAFF.H12INVITRO.0.PSM.A_homer_format_0.0005.txt MAFF.H12INVITRO.0.PSM.A_homer_format_0.0001.txt

PCM

	A	C	G	T
01	111.0	68.0	74.0	597.0
02	32.0	87.0	719.0	12.0
03	160.0	611.0	8.0	71.0
04	115.0	107.0	5.0	623.0
05	139.0	37.0	570.0	104.0
06	678.0	29.0	48.0	95.0
07	67.0	330.0	428.0	25.0
08	1.0	0.0	2.0	847.0
09	19.0	830.0	0.0	1.0
10	848.0	0.0	1.0	1.0
11	0.0	0.0	770.0	80.0
12	0.0	847.0	3.0	0.0
13	792.0	2.0	25.0	31.0
14	329.0	110.0	168.0	243.0
15	382.0	28.0	23.0	417.0
16	306.0	34.0	14.0	496.0
17	251.0	133.0	35.0	431.0
18	149.0	193.0	114.0	394.0

PFM

	A	C	G	T
01	0.131	0.08	0.087	0.702
02	0.038	0.102	0.846	0.014
03	0.188	0.719	0.009	0.084
04	0.135	0.126	0.006	0.733
05	0.164	0.044	0.671	0.122
06	0.798	0.034	0.056	0.112
07	0.079	0.388	0.504	0.029
08	0.001	0.0	0.002	0.996
09	0.022	0.976	0.0	0.001
10	0.998	0.0	0.001	0.001
11	0.0	0.0	0.906	0.094
12	0.0	0.996	0.004	0.0
13	0.932	0.002	0.029	0.036
14	0.387	0.129	0.198	0.286
15	0.449	0.033	0.027	0.491
16	0.36	0.04	0.016	0.584
17	0.295	0.156	0.041	0.507
18	0.175	0.227	0.134	0.464

PWM

	A	C	G	T
01	-0.642	-1.123	-1.04	1.028
02	-1.85	-0.882	1.213	-2.75
03	-0.281	1.051	-3.096	-1.081
04	-0.607	-0.678	-3.467	1.07
05	-0.42	-1.711	0.982	-0.706
06	1.155	-1.943	-1.461	-0.795
07	-1.137	0.437	0.696	-2.083
08	-4.379	-4.844	-4.062	1.377
09	-2.337	1.357	-4.844	-4.379
10	1.378	-4.844	-4.379	-4.379
11	-4.844	-4.844	1.282	-0.964
12	-4.844	1.377	-3.822	-4.844
13	1.31	-4.062	-2.083	-1.88
14	0.434	-0.651	-0.233	0.133
15	0.583	-1.976	-2.161	0.67
16	0.362	-1.792	-2.614	0.843
17	0.165	-0.464	-1.764	0.703
18	-0.352	-0.095	-0.616	0.614

Standard thresholds

P-value	Threshold
0.001	0.78021
0.0005	2.23436
0.0001	5.27436