MAFA.H12CORE.0.PSM.A motif - HOmo sapiens COmprehensive MOdel COllection

Motif	MAFA.H12CORE.0.PSM.A
Gene (human)	MAFA (GeneCards)
Gene synonyms (human)
Gene (mouse)	Mafa
Gene synonyms (mouse)
LOGO
LOGO (reverse complement)
Motif subtype	0
Quality	A

Motif length	18
Consensus	ndWhnTGCTGACdhndbn
GC content	48.14%
Information content (bits; total / per base)	13.63 / 0.757
Data sources	ChIP-Seq + HT-SELEX + Methyl-HT-SELEX
Aligned words	9977

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Mouse	1 (5)	0.752	0.785	0.683	0.702	0.712	0.759	2.241	2.381	92.119	107.538

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 2 experiments	median	0.998	0.996	0.992	0.989	0.939	0.935
Overall, 2 experiments	best	0.998	0.998	0.995	0.993	0.955	0.951
Methyl HT-SELEX, 1 experiments	median	0.997	0.995	0.989	0.985	0.923	0.919
Methyl HT-SELEX, 1 experiments	best	0.997	0.995	0.989	0.985	0.923	0.919
Non-Methyl HT-SELEX, 1 experiments	median	0.998	0.998	0.995	0.993	0.955	0.951
Non-Methyl HT-SELEX, 1 experiments	best	0.998	0.998	0.995	0.993	0.955	0.951

rSNP benchmarking, SNP-SELEX	auROC	auPRC	Pearson r	Kendall tau
batch 2	0.644	0.35	0.607	0.387

TF superclass	Basic domains {1} (TFClass)
TF class	Basic leucine zipper factors (bZIP) {1.1} (TFClass)
TF family	Maf-related {1.1.3} (TFClass)
TF subfamily	Large MAF {1.1.3.1} (TFClass)
TFClass ID	TFClass: 1.1.3.1.2
HGNC	HGNC:23145
MGI	MGI:2673307
EntrezGene (human)	GeneID:389692 (SSTAR profile)
EntrezGene (mouse)	GeneID:378435 (SSTAR profile)
UniProt ID (human)	MAFA_HUMAN
UniProt ID (mouse)	MAFA_MOUSE
UniProt AC (human)	Q8NHW3 (TFClass)
UniProt AC (mouse)	Q8CF90 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	0 human, 1 mouse
HT-SELEX	1
Methyl-HT-SELEX	1

PCM	MAFA.H12CORE.0.PSM.A.pcm
PWM	MAFA.H12CORE.0.PSM.A.pwm
PFM	MAFA.H12CORE.0.PSM.A.pfm
Alignment	MAFA.H12CORE.0.PSM.A.words.tsv
Threshold to P-value map	MAFA.H12CORE.0.PSM.A.thr
Motif in other formats
JASPAR format	MAFA.H12CORE.0.PSM.A_jaspar_format.txt
MEME format	MAFA.H12CORE.0.PSM.A_meme_format.meme
Transfac format	MAFA.H12CORE.0.PSM.A_transfac_format.txt
Homer format	MAFA.H12CORE.0.PSM.A_homer_format_0.001.txt MAFA.H12CORE.0.PSM.A_homer_format_0.0005.txt MAFA.H12CORE.0.PSM.A_homer_format_0.0001.txt

PCM

	A	C	G	T
01	3617.0	1896.0	2504.0	1960.0
02	4786.0	806.0	1893.0	2492.0
03	4687.0	504.0	856.0	3930.0
04	4314.0	787.0	640.0	4236.0
05	2809.0	1680.0	2026.0	3462.0
06	287.0	1173.0	94.0	8423.0
07	51.0	100.0	9776.0	50.0
08	110.0	9798.0	20.0	49.0
09	70.0	57.0	55.0	9795.0
10	81.0	24.0	9655.0	217.0
11	9808.0	98.0	31.0	40.0
12	82.0	8787.0	507.0	601.0
13	1691.0	867.0	4413.0	3006.0
14	1346.0	4087.0	1286.0	3258.0
15	3896.0	2159.0	2030.0	1892.0
16	2477.0	1598.0	4100.0	1802.0
17	1419.75	4501.75	2404.75	1650.75
18	3092.25	3072.25	2175.25	1637.25

PFM

	A	C	G	T
01	0.363	0.19	0.251	0.196
02	0.48	0.081	0.19	0.25
03	0.47	0.051	0.086	0.394
04	0.432	0.079	0.064	0.425
05	0.282	0.168	0.203	0.347
06	0.029	0.118	0.009	0.844
07	0.005	0.01	0.98	0.005
08	0.011	0.982	0.002	0.005
09	0.007	0.006	0.006	0.982
10	0.008	0.002	0.968	0.022
11	0.983	0.01	0.003	0.004
12	0.008	0.881	0.051	0.06
13	0.169	0.087	0.442	0.301
14	0.135	0.41	0.129	0.327
15	0.39	0.216	0.203	0.19
16	0.248	0.16	0.411	0.181
17	0.142	0.451	0.241	0.165
18	0.31	0.308	0.218	0.164

PWM

	A	C	G	T
01	0.371	-0.274	0.004	-0.241
02	0.651	-1.128	-0.276	-0.001
03	0.63	-1.596	-1.068	0.454
04	0.547	-1.152	-1.358	0.529
05	0.119	-0.395	-0.208	0.328
06	-2.155	-0.753	-3.255	1.216
07	-3.847	-3.195	1.365	-3.866
08	-3.101	1.368	-4.718	-3.885
09	-3.542	-3.74	-3.774	1.367
10	-3.4	-4.553	1.353	-2.432
11	1.369	-3.214	-4.317	-4.078
12	-3.388	1.259	-1.59	-1.42
13	-0.388	-1.055	0.57	0.186
14	-0.616	0.493	-0.662	0.267
15	0.446	-0.144	-0.206	-0.276
16	-0.007	-0.445	0.497	-0.325
17	-0.563	0.59	-0.037	-0.412
18	0.215	0.208	-0.137	-0.42

Standard thresholds

P-value	Threshold
0.001	3.17926
0.0005	4.38456
0.0001	6.85466