MAF.H12RSNP.1.PSM.A motif - HOmo sapiens COmprehensive MOdel COllection

Motif	MAF.H12RSNP.1.PSM.A
Gene (human)	MAF (GeneCards)
Gene synonyms (human)
Gene (mouse)	Maf
Gene synonyms (mouse)	Maf2
LOGO
LOGO (reverse complement)
Motif subtype	1
Quality	A

Motif length	13
Consensus	ndhnTGCTGACdn
GC content	52.62%
Information content (bits; total / per base)	12.751 / 0.981
Data sources	ChIP-Seq + HT-SELEX + Methyl-HT-SELEX
Aligned words	1706

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Human	5 (33)	0.737	0.782	0.643	0.723	0.721	0.782	2.173	2.393	45.387	194.959
Mouse	4 (26)	0.788	0.84	0.693	0.751	0.776	0.838	2.399	2.79	222.391	322.602

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 4 experiments	median	0.939	0.916	0.838	0.81	0.727	0.721
Overall, 4 experiments	best	0.977	0.964	0.891	0.879	0.755	0.753
Methyl HT-SELEX, 2 experiments	median	0.952	0.93	0.855	0.836	0.727	0.729
Methyl HT-SELEX, 2 experiments	best	0.977	0.964	0.891	0.879	0.74	0.753
Non-Methyl HT-SELEX, 2 experiments	median	0.939	0.916	0.828	0.808	0.714	0.712
Non-Methyl HT-SELEX, 2 experiments	best	0.94	0.922	0.857	0.827	0.755	0.739

rSNP benchmarking, SNP-SELEX	auROC	auPRC	Pearson r	Kendall tau
batch 1	0.928	0.625	0.899	0.573
batch 2	0.687	0.404	0.724	0.497

TF superclass	Basic domains {1} (TFClass)
TF class	Basic leucine zipper factors (bZIP) {1.1} (TFClass)
TF family	Maf-related {1.1.3} (TFClass)
TF subfamily	Large MAF {1.1.3.1} (TFClass)
TFClass ID	TFClass: 1.1.3.1.1
HGNC	HGNC:6776
MGI	MGI:96909
EntrezGene (human)	GeneID:4094 (SSTAR profile)
EntrezGene (mouse)	GeneID:17132 (SSTAR profile)
UniProt ID (human)	MAF_HUMAN
UniProt ID (mouse)	MAF_MOUSE
UniProt AC (human)	O75444 (TFClass)
UniProt AC (mouse)	P54843 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	5 human, 4 mouse
HT-SELEX	2
Methyl-HT-SELEX	2

PCM	MAF.H12RSNP.1.PSM.A.pcm
PWM	MAF.H12RSNP.1.PSM.A.pwm
PFM	MAF.H12RSNP.1.PSM.A.pfm
Alignment	MAF.H12RSNP.1.PSM.A.words.tsv
Threshold to P-value map	MAF.H12RSNP.1.PSM.A.thr
Motif in other formats
JASPAR format	MAF.H12RSNP.1.PSM.A_jaspar_format.txt
MEME format	MAF.H12RSNP.1.PSM.A_meme_format.meme
Transfac format	MAF.H12RSNP.1.PSM.A_transfac_format.txt
Homer format	MAF.H12RSNP.1.PSM.A_homer_format_0.001.txt MAF.H12RSNP.1.PSM.A_homer_format_0.0005.txt MAF.H12RSNP.1.PSM.A_homer_format_0.0001.txt

PCM

	A	C	G	T
01	512.75	282.75	497.75	412.75
02	610.25	233.25	310.25	552.25
03	584.0	298.0	222.0	602.0
04	486.0	250.0	468.0	502.0
05	30.0	413.0	6.0	1257.0
06	0.0	0.0	1706.0	0.0
07	0.0	1706.0	0.0	0.0
08	0.0	0.0	0.0	1706.0
09	0.0	0.0	1706.0	0.0
10	1706.0	0.0	0.0	0.0
11	8.0	1419.0	181.0	98.0
12	296.75	205.75	748.75	454.75
13	319.75	672.75	342.75	370.75

PFM

	A	C	G	T
01	0.301	0.166	0.292	0.242
02	0.358	0.137	0.182	0.324
03	0.342	0.175	0.13	0.353
04	0.285	0.147	0.274	0.294
05	0.018	0.242	0.004	0.737
06	0.0	0.0	1.0	0.0
07	0.0	1.0	0.0	0.0
08	0.0	0.0	0.0	1.0
09	0.0	0.0	1.0	0.0
10	1.0	0.0	0.0	0.0
11	0.005	0.832	0.106	0.057
12	0.174	0.121	0.439	0.267
13	0.187	0.394	0.201	0.217

PWM

	A	C	G	T
01	0.183	-0.409	0.154	-0.033
02	0.357	-0.6	-0.317	0.257
03	0.313	-0.357	-0.649	0.343
04	0.13	-0.531	0.092	0.162
05	-2.599	-0.032	-3.998	1.078
06	-5.439	-5.439	1.383	-5.439
07	-5.439	1.383	-5.439	-5.439
08	-5.439	-5.439	-5.439	1.383
09	-5.439	-5.439	1.383	-5.439
10	1.383	-5.439	-5.439	-5.439
11	-3.771	1.199	-0.851	-1.456
12	-0.361	-0.724	0.561	0.064
13	-0.287	0.454	-0.218	-0.139

Standard thresholds

P-value	Threshold
0.001	2.44601
0.0005	3.88437
0.0001	7.65197