MAF.H12INVIVO.0.PM.A motif - HOmo sapiens COmprehensive MOdel COllection

Motif	MAF.H12INVIVO.0.PM.A
Gene (human)	MAF (GeneCards)
Gene synonyms (human)
Gene (mouse)	Maf
Gene synonyms (mouse)	Maf2
LOGO
LOGO (reverse complement)
Motif subtype	0
Quality	A

Motif length	18
Consensus	nvdddnTGCTGAbdhhRb
GC content	47.37%
Information content (bits; total / per base)	11.303 / 0.628
Data sources	ChIP-Seq + Methyl-HT-SELEX
Aligned words	1007

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Human	5 (33)	0.782	0.839	0.692	0.794	0.771	0.823	2.473	3.138	48.284	244.886
Mouse	4 (26)	0.86	0.925	0.785	0.869	0.818	0.892	2.872	3.542	273.128	421.229

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 4 experiments	median	0.94	0.915	0.838	0.818	0.697	0.71
Overall, 4 experiments	best	0.979	0.973	0.863	0.856	0.763	0.742
Methyl HT-SELEX, 2 experiments	median	0.947	0.927	0.837	0.822	0.697	0.709
Methyl HT-SELEX, 2 experiments	best	0.979	0.973	0.858	0.856	0.699	0.723
Non-Methyl HT-SELEX, 2 experiments	median	0.94	0.915	0.841	0.818	0.722	0.72
Non-Methyl HT-SELEX, 2 experiments	best	0.949	0.934	0.863	0.827	0.763	0.742

rSNP benchmarking, SNP-SELEX	auROC	auPRC	Pearson r	Kendall tau
batch 1	0.936	0.302	0.928	0.556
batch 2	0.705	0.43	0.716	0.509

TF superclass	Basic domains {1} (TFClass)
TF class	Basic leucine zipper factors (bZIP) {1.1} (TFClass)
TF family	Maf-related {1.1.3} (TFClass)
TF subfamily	Large MAF {1.1.3.1} (TFClass)
TFClass ID	TFClass: 1.1.3.1.1
HGNC	HGNC:6776
MGI	MGI:96909
EntrezGene (human)	GeneID:4094 (SSTAR profile)
EntrezGene (mouse)	GeneID:17132 (SSTAR profile)
UniProt ID (human)	MAF_HUMAN
UniProt ID (mouse)	MAF_MOUSE
UniProt AC (human)	O75444 (TFClass)
UniProt AC (mouse)	P54843 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	5 human, 4 mouse
HT-SELEX	2
Methyl-HT-SELEX	2

PCM	MAF.H12INVIVO.0.PM.A.pcm
PWM	MAF.H12INVIVO.0.PM.A.pwm
PFM	MAF.H12INVIVO.0.PM.A.pfm
Alignment	MAF.H12INVIVO.0.PM.A.words.tsv
Threshold to P-value map	MAF.H12INVIVO.0.PM.A.thr
Motif in other formats
JASPAR format	MAF.H12INVIVO.0.PM.A_jaspar_format.txt
MEME format	MAF.H12INVIVO.0.PM.A_meme_format.meme
Transfac format	MAF.H12INVIVO.0.PM.A_transfac_format.txt
Homer format	MAF.H12INVIVO.0.PM.A_homer_format_0.001.txt MAF.H12INVIVO.0.PM.A_homer_format_0.0005.txt MAF.H12INVIVO.0.PM.A_homer_format_0.0001.txt

PCM

	A	C	G	T
01	303.0	197.0	285.0	222.0
02	341.0	199.0	327.0	140.0
03	485.0	115.0	219.0	188.0
04	541.0	84.0	107.0	275.0
05	364.0	102.0	125.0	416.0
06	149.0	278.0	281.0	299.0
07	99.0	47.0	32.0	829.0
08	16.0	21.0	960.0	10.0
09	101.0	876.0	9.0	21.0
10	34.0	3.0	3.0	967.0
11	13.0	12.0	931.0	51.0
12	902.0	28.0	37.0	40.0
13	65.0	488.0	310.0	144.0
14	229.0	116.0	128.0	534.0
15	213.0	485.0	116.0	193.0
16	508.0	149.0	144.0	206.0
17	202.0	50.0	579.0	176.0
18	127.0	507.0	237.0	136.0

PFM

	A	C	G	T
01	0.301	0.196	0.283	0.22
02	0.339	0.198	0.325	0.139
03	0.482	0.114	0.217	0.187
04	0.537	0.083	0.106	0.273
05	0.361	0.101	0.124	0.413
06	0.148	0.276	0.279	0.297
07	0.098	0.047	0.032	0.823
08	0.016	0.021	0.953	0.01
09	0.1	0.87	0.009	0.021
10	0.034	0.003	0.003	0.96
11	0.013	0.012	0.925	0.051
12	0.896	0.028	0.037	0.04
13	0.065	0.485	0.308	0.143
14	0.227	0.115	0.127	0.53
15	0.212	0.482	0.115	0.192
16	0.504	0.148	0.143	0.205
17	0.201	0.05	0.575	0.175
18	0.126	0.503	0.235	0.135

PWM

	A	C	G	T
01	0.184	-0.243	0.123	-0.125
02	0.302	-0.233	0.26	-0.581
03	0.652	-0.775	-0.138	-0.29
04	0.761	-1.084	-0.846	0.088
05	0.367	-0.894	-0.693	0.5
06	-0.52	0.099	0.109	0.171
07	-0.923	-1.649	-2.017	1.187
08	-2.66	-2.412	1.333	-3.073
09	-0.903	1.242	-3.162	-2.412
10	-1.959	-3.982	-3.982	1.341
11	-2.845	-2.916	1.303	-1.57
12	1.271	-2.143	-1.879	-1.804
13	-1.335	0.659	0.207	-0.554
14	-0.094	-0.767	-0.67	0.748
15	-0.166	0.652	-0.767	-0.264
16	0.699	-0.52	-0.554	-0.199
17	-0.218	-1.589	0.829	-0.355
18	-0.678	0.697	-0.06	-0.61

Standard thresholds

P-value	Threshold
0.001	4.40986
0.0005	5.31656
0.0001	7.19261