KLF6.H12INVIVO.1.SM.B motif - HOmo sapiens COmprehensive MOdel COllection

Motif	KLF6.H12INVIVO.1.SM.B
Gene (human)	KLF6 (GeneCards)
Gene synonyms (human)	BCD1, COPEB, CPBP, ST12
Gene (mouse)	Klf6
Gene synonyms (mouse)	Copeb, Cpbp
LOGO
LOGO (reverse complement)
Motif subtype	1
Quality	B

Motif length	13
Consensus	dddGGGCGTGGbn
GC content	73.28%
Information content (bits; total / per base)	14.58 / 1.122
Data sources	HT-SELEX + Methyl-HT-SELEX
Aligned words	9325

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Human	2 (12)	0.706	0.756	0.503	0.548	0.754	0.823	2.14	2.438	4.99	51.569

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 2 experiments	median	0.889	0.847	0.805	0.77	0.701	0.69
Overall, 2 experiments	best	0.929	0.89	0.867	0.827	0.76	0.741
Methyl HT-SELEX, 1 experiments	median	0.929	0.89	0.867	0.827	0.76	0.741
Methyl HT-SELEX, 1 experiments	best	0.929	0.89	0.867	0.827	0.76	0.741
Non-Methyl HT-SELEX, 1 experiments	median	0.85	0.804	0.743	0.713	0.643	0.64
Non-Methyl HT-SELEX, 1 experiments	best	0.85	0.804	0.743	0.713	0.643	0.64

TF superclass	Zinc-coordinating DNA-binding domains {2} (TFClass)
TF class	C2H2 zinc finger factors {2.3} (TFClass)
TF family	Three-zinc finger Kruppel-related {2.3.1} (TFClass)
TF subfamily	Kr-like {2.3.1.2} (TFClass)
TFClass ID	TFClass: 2.3.1.2.6
HGNC	HGNC:2235
MGI	MGI:1346318
EntrezGene (human)	GeneID:1316 (SSTAR profile)
EntrezGene (mouse)
UniProt ID (human)	KLF6_HUMAN
UniProt ID (mouse)	KLF6_MOUSE
UniProt AC (human)	Q99612 (TFClass)
UniProt AC (mouse)	O08584 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	2 human, 0 mouse
HT-SELEX	1
Methyl-HT-SELEX	1

PCM	KLF6.H12INVIVO.1.SM.B.pcm
PWM	KLF6.H12INVIVO.1.SM.B.pwm
PFM	KLF6.H12INVIVO.1.SM.B.pfm
Alignment	KLF6.H12INVIVO.1.SM.B.words.tsv
Threshold to P-value map	KLF6.H12INVIVO.1.SM.B.thr
Motif in other formats
JASPAR format	KLF6.H12INVIVO.1.SM.B_jaspar_format.txt
MEME format	KLF6.H12INVIVO.1.SM.B_meme_format.meme
Transfac format	KLF6.H12INVIVO.1.SM.B_transfac_format.txt
Homer format	KLF6.H12INVIVO.1.SM.B_homer_format_0.001.txt KLF6.H12INVIVO.1.SM.B_homer_format_0.0005.txt KLF6.H12INVIVO.1.SM.B_homer_format_0.0001.txt

PCM

	A	C	G	T
01	1705.25	1504.25	4189.25	1926.25
02	2430.5	884.5	4045.5	1964.5
03	3151.0	548.0	2350.0	3276.0
04	846.0	0.0	8472.0	7.0
05	0.0	1.0	9324.0	0.0
06	0.0	0.0	9325.0	0.0
07	40.0	8993.0	0.0	292.0
08	1.0	0.0	9324.0	0.0
09	33.0	44.0	692.0	8556.0
10	244.0	132.0	8826.0	123.0
11	334.0	108.0	8120.0	763.0
12	689.0	4521.0	1713.0	2402.0
13	2022.5	2470.5	3249.5	1582.5

PFM

	A	C	G	T
01	0.183	0.161	0.449	0.207
02	0.261	0.095	0.434	0.211
03	0.338	0.059	0.252	0.351
04	0.091	0.0	0.909	0.001
05	0.0	0.0	1.0	0.0
06	0.0	0.0	1.0	0.0
07	0.004	0.964	0.0	0.031
08	0.0	0.0	1.0	0.0
09	0.004	0.005	0.074	0.918
10	0.026	0.014	0.946	0.013
11	0.036	0.012	0.871	0.082
12	0.074	0.485	0.184	0.258
13	0.217	0.265	0.348	0.17

PWM

	A	C	G	T
01	-0.312	-0.438	0.586	-0.191
02	0.042	-0.968	0.551	-0.171
03	0.301	-1.445	0.008	0.34
04	-1.012	-6.929	1.29	-5.527
05	-6.929	-6.566	1.385	-6.929
06	-6.929	-6.929	1.386	-6.929
07	-4.011	1.349	-6.929	-2.071
08	-6.566	-6.929	1.385	-6.929
09	-4.192	-3.92	-1.212	1.3
10	-2.249	-2.855	1.331	-2.925
11	-1.937	-3.052	1.247	-1.115
12	-1.217	0.662	-0.308	0.03
13	-0.142	0.058	0.332	-0.387

Standard thresholds

P-value	Threshold
0.001	1.73636
0.0005	3.35306
0.0001	6.561365