KLF6.H12CORE.1.SM.B motif - HOmo sapiens COmprehensive MOdel COllection

Motif	KLF6.H12CORE.1.SM.B
Gene (human)	KLF6 (GeneCards)
Gene synonyms (human)	BCD1, COPEB, CPBP, ST12
Gene (mouse)	Klf6
Gene synonyms (mouse)	Copeb, Cpbp
LOGO
LOGO (reverse complement)
Motif subtype	1
Quality	B

Motif length	14
Consensus	bdddWGGGCGTKKb
GC content	66.09%
Information content (bits; total / per base)	13.39 / 0.956
Data sources	HT-SELEX + Methyl-HT-SELEX
Aligned words	6748

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Human	2 (12)	0.707	0.75	0.52	0.54	0.734	0.794	2.008	2.193	7.186	49.854

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 2 experiments	median	0.884	0.835	0.801	0.761	0.698	0.683
Overall, 2 experiments	best	0.907	0.857	0.843	0.797	0.742	0.718
Methyl HT-SELEX, 1 experiments	median	0.907	0.857	0.843	0.797	0.742	0.718
Methyl HT-SELEX, 1 experiments	best	0.907	0.857	0.843	0.797	0.742	0.718
Non-Methyl HT-SELEX, 1 experiments	median	0.862	0.813	0.759	0.725	0.653	0.648
Non-Methyl HT-SELEX, 1 experiments	best	0.862	0.813	0.759	0.725	0.653	0.648

TF superclass	Zinc-coordinating DNA-binding domains {2} (TFClass)
TF class	C2H2 zinc finger factors {2.3} (TFClass)
TF family	Three-zinc finger Kruppel-related {2.3.1} (TFClass)
TF subfamily	Kr-like {2.3.1.2} (TFClass)
TFClass ID	TFClass: 2.3.1.2.6
HGNC	HGNC:2235
MGI	MGI:1346318
EntrezGene (human)	GeneID:1316 (SSTAR profile)
EntrezGene (mouse)
UniProt ID (human)	KLF6_HUMAN
UniProt ID (mouse)	KLF6_MOUSE
UniProt AC (human)	Q99612 (TFClass)
UniProt AC (mouse)	O08584 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	2 human, 0 mouse
HT-SELEX	1
Methyl-HT-SELEX	1

PCM	KLF6.H12CORE.1.SM.B.pcm
PWM	KLF6.H12CORE.1.SM.B.pwm
PFM	KLF6.H12CORE.1.SM.B.pfm
Alignment	KLF6.H12CORE.1.SM.B.words.tsv
Threshold to P-value map	KLF6.H12CORE.1.SM.B.thr
Motif in other formats
JASPAR format	KLF6.H12CORE.1.SM.B_jaspar_format.txt
MEME format	KLF6.H12CORE.1.SM.B_meme_format.meme
Transfac format	KLF6.H12CORE.1.SM.B_transfac_format.txt
Homer format	KLF6.H12CORE.1.SM.B_homer_format_0.001.txt KLF6.H12CORE.1.SM.B_homer_format_0.0005.txt KLF6.H12CORE.1.SM.B_homer_format_0.0001.txt

PCM

	A	C	G	T
01	1136.0	1166.0	2856.0	1590.0
02	1111.5	873.5	3176.5	1586.5
03	1137.0	792.0	3078.0	1741.0
04	2154.0	423.0	2248.0	1923.0
05	2510.0	54.0	1191.0	2993.0
06	102.0	1.0	6644.0	1.0
07	0.0	1.0	6747.0	0.0
08	0.0	0.0	6748.0	0.0
09	11.0	6102.0	0.0	635.0
10	0.0	0.0	6748.0	0.0
11	52.0	8.0	284.0	6404.0
12	953.0	180.0	4485.0	1130.0
13	785.75	525.75	4143.75	1292.75
14	741.0	1895.0	2069.0	2043.0

PFM

	A	C	G	T
01	0.168	0.173	0.423	0.236
02	0.165	0.129	0.471	0.235
03	0.168	0.117	0.456	0.258
04	0.319	0.063	0.333	0.285
05	0.372	0.008	0.176	0.444
06	0.015	0.0	0.985	0.0
07	0.0	0.0	1.0	0.0
08	0.0	0.0	1.0	0.0
09	0.002	0.904	0.0	0.094
10	0.0	0.0	1.0	0.0
11	0.008	0.001	0.042	0.949
12	0.141	0.027	0.665	0.167
13	0.116	0.078	0.614	0.192
14	0.11	0.281	0.307	0.303

PWM

	A	C	G	T
01	-0.395	-0.369	0.526	-0.059
02	-0.417	-0.657	0.632	-0.061
03	-0.394	-0.755	0.601	0.031
04	0.244	-1.379	0.287	0.131
05	0.397	-3.403	-0.348	0.573
06	-2.786	-6.268	1.37	-6.268
07	-6.642	-6.268	1.385	-6.642
08	-6.642	-6.642	1.385	-6.642
09	-4.851	1.285	-6.642	-0.975
10	-6.642	-6.642	1.385	-6.642
11	-3.439	-5.109	-1.775	1.333
12	-0.57	-2.227	0.977	-0.4
13	-0.763	-1.163	0.898	-0.266
14	-0.821	0.116	0.204	0.191

Standard thresholds

P-value	Threshold
0.001	2.35196
0.0005	4.03576
0.0001	7.229365