KLF5.H12INVIVO.0.PM.A motif - HOmo sapiens COmprehensive MOdel COllection

Motif	KLF5.H12INVIVO.0.PM.A
Gene (human)	KLF5 (GeneCards)
Gene synonyms (human)	BTEB2, CKLF, IKLF
Gene (mouse)	Klf5
Gene synonyms (mouse)	Bteb2, Iklf
LOGO
LOGO (reverse complement)
Motif subtype	0
Quality	A

Motif length	13
Consensus	ndGGGYGKGRYhb
GC content	66.97%
Information content (bits; total / per base)	11.284 / 0.868
Data sources	ChIP-Seq + Methyl-HT-SELEX
Aligned words	998

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Human	14 (86)	0.842	0.909	0.718	0.818	0.856	0.933	3.079	3.683	94.761	238.18
Mouse	7 (47)	0.837	0.881	0.716	0.803	0.829	0.885	2.841	3.389	73.137	159.854

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Methyl HT-SELEX, 1 experiments	median	0.832	0.78	0.708	0.687	0.592	0.609
Methyl HT-SELEX, 1 experiments	best	0.832	0.78	0.708	0.687	0.592	0.609

rSNP benchmarking, ADASTRA	odds-ratio	-log-Fisher's P	Pearson r	Kendall tau
#	2.103	1.591	0.152	0.051

TF superclass	Zinc-coordinating DNA-binding domains {2} (TFClass)
TF class	C2H2 zinc finger factors {2.3} (TFClass)
TF family	Three-zinc finger Kruppel-related {2.3.1} (TFClass)
TF subfamily	Kr-like {2.3.1.2} (TFClass)
TFClass ID	TFClass: 2.3.1.2.5
HGNC	HGNC:6349
MGI	MGI:1338056
EntrezGene (human)	GeneID:688 (SSTAR profile)
EntrezGene (mouse)	GeneID:12224 (SSTAR profile)
UniProt ID (human)	KLF5_HUMAN
UniProt ID (mouse)	KLF5_MOUSE
UniProt AC (human)	Q13887 (TFClass)
UniProt AC (mouse)	Q9Z0Z7 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	14 human, 7 mouse
HT-SELEX	0
Methyl-HT-SELEX	1

PCM	KLF5.H12INVIVO.0.PM.A.pcm
PWM	KLF5.H12INVIVO.0.PM.A.pwm
PFM	KLF5.H12INVIVO.0.PM.A.pfm
Alignment	KLF5.H12INVIVO.0.PM.A.words.tsv
Threshold to P-value map	KLF5.H12INVIVO.0.PM.A.thr
Motif in other formats
JASPAR format	KLF5.H12INVIVO.0.PM.A_jaspar_format.txt
MEME format	KLF5.H12INVIVO.0.PM.A_meme_format.meme
Transfac format	KLF5.H12INVIVO.0.PM.A_transfac_format.txt
Homer format	KLF5.H12INVIVO.0.PM.A_homer_format_0.001.txt KLF5.H12INVIVO.0.PM.A_homer_format_0.0005.txt KLF5.H12INVIVO.0.PM.A_homer_format_0.0001.txt

PCM

	A	C	G	T
01	260.0	337.0	204.0	197.0
02	410.0	34.0	182.0	372.0
03	72.0	3.0	903.0	20.0
04	2.0	3.0	989.0	4.0
05	10.0	11.0	974.0	3.0
06	152.0	302.0	3.0	541.0
07	18.0	7.0	957.0	16.0
08	24.0	28.0	314.0	632.0
09	36.0	13.0	916.0	33.0
10	214.0	57.0	597.0	130.0
11	93.0	671.0	85.0	149.0
12	252.0	344.0	104.0	298.0
13	172.0	256.0	395.0	175.0

PFM

	A	C	G	T
01	0.261	0.338	0.204	0.197
02	0.411	0.034	0.182	0.373
03	0.072	0.003	0.905	0.02
04	0.002	0.003	0.991	0.004
05	0.01	0.011	0.976	0.003
06	0.152	0.303	0.003	0.542
07	0.018	0.007	0.959	0.016
08	0.024	0.028	0.315	0.633
09	0.036	0.013	0.918	0.033
10	0.214	0.057	0.598	0.13
11	0.093	0.672	0.085	0.149
12	0.253	0.345	0.104	0.299
13	0.172	0.257	0.396	0.175

PWM

	A	C	G	T
01	0.041	0.299	-0.2	-0.234
02	0.494	-1.95	-0.313	0.397
03	-1.226	-3.973	1.281	-2.448
04	-4.211	-3.973	1.372	-3.781
05	-3.065	-2.983	1.357	-3.973
06	-0.491	0.19	-3.973	0.77
07	-2.544	-3.36	1.339	-2.651
08	-2.279	-2.134	0.229	0.925
09	-1.896	-2.837	1.296	-1.979
10	-0.152	-1.453	0.868	-0.646
11	-0.975	0.985	-1.064	-0.511
12	0.01	0.319	-0.865	0.177
13	-0.369	0.026	0.457	-0.352

Standard thresholds

P-value	Threshold
0.001	4.34366
0.0005	5.32271
0.0001	7.37912