KLF5.H12INVITRO.0.PM.A motif - HOmo sapiens COmprehensive MOdel COllection

Motif	KLF5.H12INVITRO.0.PM.A
Gene (human)	KLF5 (GeneCards)
Gene synonyms (human)	BTEB2, CKLF, IKLF
Gene (mouse)	Klf5
Gene synonyms (mouse)	Bteb2, Iklf
LOGO
LOGO (reverse complement)
Motif subtype	0
Quality	A

Motif length	11
Consensus	ndRGGCGKGdn
GC content	67.43%
Information content (bits; total / per base)	9.776 / 0.889
Data sources	ChIP-Seq + Methyl-HT-SELEX
Aligned words	8383

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Human	14 (86)	0.788	0.85	0.623	0.728	0.801	0.871	2.299	2.848	65.003	197.959
Mouse	7 (47)	0.804	0.847	0.623	0.709	0.758	0.802	2.017	2.29	56.237	133.143

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Methyl HT-SELEX, 1 experiments	median	0.859	0.812	0.763	0.727	0.674	0.658
Methyl HT-SELEX, 1 experiments	best	0.859	0.812	0.763	0.727	0.674	0.658

rSNP benchmarking, ADASTRA	odds-ratio	-log-Fisher's P	Pearson r	Kendall tau
#	2.697	2.278	0.141	0.056

TF superclass	Zinc-coordinating DNA-binding domains {2} (TFClass)
TF class	C2H2 zinc finger factors {2.3} (TFClass)
TF family	Three-zinc finger Kruppel-related {2.3.1} (TFClass)
TF subfamily	Kr-like {2.3.1.2} (TFClass)
TFClass ID	TFClass: 2.3.1.2.5
HGNC	HGNC:6349
MGI	MGI:1338056
EntrezGene (human)	GeneID:688 (SSTAR profile)
EntrezGene (mouse)	GeneID:12224 (SSTAR profile)
UniProt ID (human)	KLF5_HUMAN
UniProt ID (mouse)	KLF5_MOUSE
UniProt AC (human)	Q13887 (TFClass)
UniProt AC (mouse)	Q9Z0Z7 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	14 human, 7 mouse
HT-SELEX	0
Methyl-HT-SELEX	1

PCM	KLF5.H12INVITRO.0.PM.A.pcm
PWM	KLF5.H12INVITRO.0.PM.A.pwm
PFM	KLF5.H12INVITRO.0.PM.A.pfm
Alignment	KLF5.H12INVITRO.0.PM.A.words.tsv
Threshold to P-value map	KLF5.H12INVITRO.0.PM.A.thr
Motif in other formats
JASPAR format	KLF5.H12INVITRO.0.PM.A_jaspar_format.txt
MEME format	KLF5.H12INVITRO.0.PM.A_meme_format.meme
Transfac format	KLF5.H12INVITRO.0.PM.A_transfac_format.txt
Homer format	KLF5.H12INVITRO.0.PM.A_homer_format_0.001.txt KLF5.H12INVITRO.0.PM.A_homer_format_0.0005.txt KLF5.H12INVITRO.0.PM.A_homer_format_0.0001.txt

PCM

	A	C	G	T
01	2181.75	1577.75	2569.75	2053.75
02	3550.5	980.5	1712.5	2139.5
03	2565.0	9.0	5471.0	338.0
04	0.0	965.0	7409.0	9.0
05	0.0	0.0	8383.0	0.0
06	293.0	7025.0	0.0	1065.0
07	198.0	1.0	8173.0	11.0
08	465.0	637.0	657.0	6624.0
09	808.0	124.0	6765.0	686.0
10	1474.0	876.0	3871.0	2162.0
11	1478.5	2630.5	2341.5	1932.5

PFM

	A	C	G	T
01	0.26	0.188	0.307	0.245
02	0.424	0.117	0.204	0.255
03	0.306	0.001	0.653	0.04
04	0.0	0.115	0.884	0.001
05	0.0	0.0	1.0	0.0
06	0.035	0.838	0.0	0.127
07	0.024	0.0	0.975	0.001
08	0.055	0.076	0.078	0.79
09	0.096	0.015	0.807	0.082
10	0.176	0.104	0.462	0.258
11	0.176	0.314	0.279	0.231

PWM

	A	C	G	T
01	0.04	-0.284	0.204	-0.02
02	0.527	-0.758	-0.202	0.021
03	0.202	-5.228	0.959	-1.819
04	-6.834	-0.774	1.262	-5.228
05	-6.834	-6.834	1.385	-6.834
06	-1.961	1.209	-6.834	-0.676
07	-2.349	-6.467	1.36	-5.064
08	-1.502	-1.188	-1.158	1.15
09	-0.951	-2.81	1.171	-1.115
10	-0.351	-0.871	0.613	0.031
11	-0.348	0.227	0.111	-0.081

Standard thresholds

P-value	Threshold
0.001	4.948525
0.0005	5.8314
0.0001	7.403035