KLF4.H12INVIVO.0.PSM.A motif - HOmo sapiens COmprehensive MOdel COllection

Motif	KLF4.H12INVIVO.0.PSM.A
Gene (human)	KLF4 (GeneCards)
Gene synonyms (human)	EZF, GKLF
Gene (mouse)	Klf4
Gene synonyms (mouse)	Ezf, Gklf, Zie
LOGO
LOGO (reverse complement)
Motif subtype	0
Quality	A

Motif length	14
Consensus	vndGGGYGKGKYbb
GC content	71.24%
Information content (bits; total / per base)	12.637 / 0.903
Data sources	ChIP-Seq + HT-SELEX + Methyl-HT-SELEX
Aligned words	991

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Human	17 (101)	0.804	0.888	0.693	0.78	0.826	0.938	3.005	3.746	71.481	260.092
Mouse	58 (353)	0.877	0.949	0.781	0.905	0.89	0.954	3.513	4.581	129.638	359.268

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 2 experiments	median	0.91	0.86	0.858	0.809	0.772	0.739
Overall, 2 experiments	best	0.921	0.877	0.863	0.819	0.784	0.741
Methyl HT-SELEX, 1 experiments	median	0.899	0.844	0.853	0.799	0.784	0.741
Methyl HT-SELEX, 1 experiments	best	0.899	0.844	0.853	0.799	0.784	0.741
Non-Methyl HT-SELEX, 1 experiments	median	0.921	0.877	0.863	0.819	0.761	0.738
Non-Methyl HT-SELEX, 1 experiments	best	0.921	0.877	0.863	0.819	0.761	0.738

TF superclass	Zinc-coordinating DNA-binding domains {2} (TFClass)
TF class	C2H2 zinc finger factors {2.3} (TFClass)
TF family	Three-zinc finger Kruppel-related {2.3.1} (TFClass)
TF subfamily	Kr-like {2.3.1.2} (TFClass)
TFClass ID	TFClass: 2.3.1.2.4
HGNC	HGNC:6348
MGI	MGI:1342287
EntrezGene (human)	GeneID:9314 (SSTAR profile)
EntrezGene (mouse)	GeneID:16600 (SSTAR profile)
UniProt ID (human)	KLF4_HUMAN
UniProt ID (mouse)	KLF4_MOUSE
UniProt AC (human)	O43474 (TFClass)
UniProt AC (mouse)	Q60793 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	17 human, 58 mouse
HT-SELEX	1
Methyl-HT-SELEX	1

PCM	KLF4.H12INVIVO.0.PSM.A.pcm
PWM	KLF4.H12INVIVO.0.PSM.A.pwm
PFM	KLF4.H12INVIVO.0.PSM.A.pfm
Alignment	KLF4.H12INVIVO.0.PSM.A.words.tsv
Threshold to P-value map	KLF4.H12INVIVO.0.PSM.A.thr
Motif in other formats
JASPAR format	KLF4.H12INVIVO.0.PSM.A_jaspar_format.txt
MEME format	KLF4.H12INVIVO.0.PSM.A_meme_format.meme
Transfac format	KLF4.H12INVIVO.0.PSM.A_transfac_format.txt
Homer format	KLF4.H12INVIVO.0.PSM.A_homer_format_0.001.txt KLF4.H12INVIVO.0.PSM.A_homer_format_0.0005.txt KLF4.H12INVIVO.0.PSM.A_homer_format_0.0001.txt

PCM

	A	C	G	T
01	241.0	217.0	389.0	144.0
02	275.0	323.0	235.0	158.0
03	401.0	28.0	147.0	415.0
04	33.0	1.0	955.0	2.0
05	4.0	5.0	975.0	7.0
06	9.0	8.0	973.0	1.0
07	12.0	459.0	3.0	517.0
08	3.0	2.0	983.0	3.0
09	6.0	41.0	401.0	543.0
10	59.0	29.0	824.0	79.0
11	41.0	62.0	771.0	117.0
12	31.0	628.0	70.0	262.0
13	97.0	473.0	149.0	272.0
14	112.0	379.0	354.0	146.0

PFM

	A	C	G	T
01	0.243	0.219	0.393	0.145
02	0.277	0.326	0.237	0.159
03	0.405	0.028	0.148	0.419
04	0.033	0.001	0.964	0.002
05	0.004	0.005	0.984	0.007
06	0.009	0.008	0.982	0.001
07	0.012	0.463	0.003	0.522
08	0.003	0.002	0.992	0.003
09	0.006	0.041	0.405	0.548
10	0.06	0.029	0.831	0.08
11	0.041	0.063	0.778	0.118
12	0.031	0.634	0.071	0.264
13	0.098	0.477	0.15	0.274
14	0.113	0.382	0.357	0.147

PWM

	A	C	G	T
01	-0.027	-0.132	0.449	-0.538
02	0.104	0.264	-0.052	-0.446
03	0.479	-2.127	-0.517	0.513
04	-1.972	-4.517	1.344	-4.204
05	-3.775	-3.614	1.365	-3.353
06	-3.147	-3.245	1.363	-4.517
07	-2.9	0.613	-3.967	0.732
08	-3.967	-4.204	1.373	-3.967
09	-3.475	-1.765	0.479	0.781
10	-1.413	-2.094	1.197	-1.128
11	-1.765	-1.365	1.131	-0.743
12	-2.031	0.926	-1.247	0.056
13	-0.927	0.643	-0.504	0.093
14	-0.786	0.423	0.355	-0.524

Standard thresholds

P-value	Threshold
0.001	3.78111
0.0005	4.91211
0.0001	7.20961