KLF4.H12CORE.0.PSM.A motif - HOmo sapiens COmprehensive MOdel COllection

Motif	KLF4.H12CORE.0.PSM.A
Gene (human)	KLF4 (GeneCards)
Gene synonyms (human)	EZF, GKLF
Gene (mouse)	Klf4
Gene synonyms (mouse)	Ezf, Gklf, Zie
LOGO
LOGO (reverse complement)
Motif subtype	0
Quality	A

Motif length	11
Consensus	WGGGYGKKKYb
GC content	71.17%
Information content (bits; total / per base)	11.855 / 1.078
Data sources	ChIP-Seq + HT-SELEX + Methyl-HT-SELEX
Aligned words	1000

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Human	17 (101)	0.81	0.89	0.699	0.783	0.829	0.92	2.885	3.421	65.119	257.097
Mouse	58 (353)	0.874	0.948	0.779	0.907	0.884	0.944	3.354	4.097	123.553	372.114

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 2 experiments	median	0.922	0.88	0.865	0.821	0.78	0.749
Overall, 2 experiments	best	0.929	0.891	0.87	0.829	0.792	0.752
Methyl HT-SELEX, 1 experiments	median	0.915	0.869	0.86	0.813	0.792	0.752
Methyl HT-SELEX, 1 experiments	best	0.915	0.869	0.86	0.813	0.792	0.752
Non-Methyl HT-SELEX, 1 experiments	median	0.929	0.891	0.87	0.829	0.768	0.746
Non-Methyl HT-SELEX, 1 experiments	best	0.929	0.891	0.87	0.829	0.768	0.746

TF superclass	Zinc-coordinating DNA-binding domains {2} (TFClass)
TF class	C2H2 zinc finger factors {2.3} (TFClass)
TF family	Three-zinc finger Kruppel-related {2.3.1} (TFClass)
TF subfamily	Kr-like {2.3.1.2} (TFClass)
TFClass ID	TFClass: 2.3.1.2.4
HGNC	HGNC:6348
MGI	MGI:1342287
EntrezGene (human)	GeneID:9314 (SSTAR profile)
EntrezGene (mouse)	GeneID:16600 (SSTAR profile)
UniProt ID (human)	KLF4_HUMAN
UniProt ID (mouse)	KLF4_MOUSE
UniProt AC (human)	O43474 (TFClass)
UniProt AC (mouse)	Q60793 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	17 human, 58 mouse
HT-SELEX	1
Methyl-HT-SELEX	1

PCM	KLF4.H12CORE.0.PSM.A.pcm
PWM	KLF4.H12CORE.0.PSM.A.pwm
PFM	KLF4.H12CORE.0.PSM.A.pfm
Alignment	KLF4.H12CORE.0.PSM.A.words.tsv
Threshold to P-value map	KLF4.H12CORE.0.PSM.A.thr
Motif in other formats
JASPAR format	KLF4.H12CORE.0.PSM.A_jaspar_format.txt
MEME format	KLF4.H12CORE.0.PSM.A_meme_format.meme
Transfac format	KLF4.H12CORE.0.PSM.A_transfac_format.txt
Homer format	KLF4.H12CORE.0.PSM.A_homer_format_0.001.txt KLF4.H12CORE.0.PSM.A_homer_format_0.0005.txt KLF4.H12CORE.0.PSM.A_homer_format_0.0001.txt

PCM

	A	C	G	T
01	380.0	27.0	107.0	486.0
02	12.25	1.25	983.25	3.25
03	5.25	2.25	990.25	2.25
04	8.25	5.25	983.25	3.25
05	41.25	384.25	3.25	571.25
06	12.25	9.25	966.25	12.25
07	8.25	30.25	405.25	556.25
08	82.25	15.25	791.25	111.25
09	42.25	81.25	752.25	124.25
10	51.25	582.25	104.25	262.25
11	135.25	429.25	175.25	260.25

PFM

	A	C	G	T
01	0.38	0.027	0.107	0.486
02	0.012	0.001	0.983	0.003
03	0.005	0.002	0.99	0.002
04	0.008	0.005	0.983	0.003
05	0.041	0.384	0.003	0.571
06	0.012	0.009	0.966	0.012
07	0.008	0.03	0.405	0.556
08	0.082	0.015	0.791	0.111
09	0.042	0.081	0.752	0.124
10	0.051	0.582	0.104	0.262
11	0.135	0.429	0.175	0.26

PWM

	A	C	G	T
01	0.416	-2.171	-0.84	0.661
02	-2.891	-4.437	1.364	-3.924
03	-3.586	-4.148	1.371	-4.148
04	-3.228	-3.586	1.364	-3.924
05	-1.768	0.427	-3.924	0.823
06	-2.891	-3.133	1.347	-2.891
07	-3.228	-2.063	0.48	0.796
08	-1.098	-2.696	1.147	-0.801
09	-1.745	-1.11	1.097	-0.692
10	-1.558	0.842	-0.865	0.048
11	-0.609	0.538	-0.352	0.04

Standard thresholds

P-value	Threshold
0.001	4.07092
0.0005	5.18228
0.0001	7.37314