KLF3.H12RSNP.1.M.D motif - HOmo sapiens COmprehensive MOdel COllection

Motif	KLF3.H12RSNP.1.M.D
Gene (human)	KLF3 (GeneCards)
Gene synonyms (human)	BKLF
Gene (mouse)	Klf3
Gene synonyms (mouse)	Bklf
LOGO
LOGO (reverse complement)
Motif subtype	1
Quality	D

Motif length	13
Consensus	ddGGGCKKSGbbn
GC content	71.04%
Information content (bits; total / per base)	11.884 / 0.914
Data sources	Methyl-HT-SELEX
Aligned words	6205

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Human	1 (6)	0.627	0.641	0.436	0.446	0.661	0.718	1.759	1.928	0.889	1.796
Mouse	3 (21)	0.721	0.818	0.57	0.66	0.741	0.884	2.244	2.975	54.585	105.638

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 2 experiments	median	0.867	0.83	0.755	0.738	0.634	0.649
Overall, 2 experiments	best	0.946	0.921	0.853	0.83	0.701	0.714
Methyl HT-SELEX, 1 experiments	median	0.946	0.921	0.853	0.83	0.701	0.714
Methyl HT-SELEX, 1 experiments	best	0.946	0.921	0.853	0.83	0.701	0.714
Non-Methyl HT-SELEX, 1 experiments	median	0.788	0.739	0.656	0.646	0.566	0.583
Non-Methyl HT-SELEX, 1 experiments	best	0.788	0.739	0.656	0.646	0.566	0.583

TF superclass	Zinc-coordinating DNA-binding domains {2} (TFClass)
TF class	C2H2 zinc finger factors {2.3} (TFClass)
TF family	Three-zinc finger Kruppel-related {2.3.1} (TFClass)
TF subfamily	Kr-like {2.3.1.2} (TFClass)
TFClass ID	TFClass: 2.3.1.2.3
HGNC	HGNC:16516
MGI	MGI:1342773
EntrezGene (human)	GeneID:51274 (SSTAR profile)
EntrezGene (mouse)	GeneID:16599 (SSTAR profile)
UniProt ID (human)	KLF3_HUMAN
UniProt ID (mouse)	KLF3_MOUSE
UniProt AC (human)	P57682 (TFClass)
UniProt AC (mouse)	Q60980 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	1 human, 3 mouse
HT-SELEX	1
Methyl-HT-SELEX	1

PCM	KLF3.H12RSNP.1.M.D.pcm
PWM	KLF3.H12RSNP.1.M.D.pwm
PFM	KLF3.H12RSNP.1.M.D.pfm
Alignment	KLF3.H12RSNP.1.M.D.words.tsv
Threshold to P-value map	KLF3.H12RSNP.1.M.D.thr
Motif in other formats
JASPAR format	KLF3.H12RSNP.1.M.D_jaspar_format.txt
MEME format	KLF3.H12RSNP.1.M.D_meme_format.meme
Transfac format	KLF3.H12RSNP.1.M.D_transfac_format.txt
Homer format	KLF3.H12RSNP.1.M.D_homer_format_0.001.txt KLF3.H12RSNP.1.M.D_homer_format_0.0005.txt KLF3.H12RSNP.1.M.D_homer_format_0.0001.txt

PCM

	A	C	G	T
01	2054.0	620.0	1662.0	1869.0
02	2415.0	507.0	870.0	2413.0
03	22.0	0.0	6179.0	4.0
04	0.0	1.0	6204.0	0.0
05	0.0	2.0	6203.0	0.0
06	56.0	5328.0	0.0	821.0
07	32.0	0.0	2781.0	3392.0
08	112.0	725.0	2776.0	2592.0
09	198.0	2474.0	3279.0	254.0
10	177.0	156.0	5635.0	237.0
11	140.0	2396.0	2044.0	1625.0
12	571.25	3235.25	641.25	1757.25
13	1133.25	2277.25	1306.25	1488.25

PFM

	A	C	G	T
01	0.331	0.1	0.268	0.301
02	0.389	0.082	0.14	0.389
03	0.004	0.0	0.996	0.001
04	0.0	0.0	1.0	0.0
05	0.0	0.0	1.0	0.0
06	0.009	0.859	0.0	0.132
07	0.005	0.0	0.448	0.547
08	0.018	0.117	0.447	0.418
09	0.032	0.399	0.528	0.041
10	0.029	0.025	0.908	0.038
11	0.023	0.386	0.329	0.262
12	0.092	0.521	0.103	0.283
13	0.183	0.367	0.211	0.24

PWM

	A	C	G	T
01	0.28	-0.915	0.069	0.186
02	0.442	-1.115	-0.577	0.441
03	-4.163	-6.567	1.381	-5.526
04	-6.567	-6.19	1.385	-6.567
05	-6.567	-5.917	1.385	-6.567
06	-3.285	1.233	-6.567	-0.635
07	-3.816	-6.567	0.583	0.782
08	-2.61	-0.759	0.581	0.513
09	-2.049	0.466	0.748	-1.802
10	-2.16	-2.284	1.289	-1.871
11	-2.391	0.434	0.276	0.046
12	-0.997	0.734	-0.881	0.125
13	-0.313	0.383	-0.172	-0.041

Standard thresholds

P-value	Threshold
0.001	3.85581
0.0005	5.15511
0.0001	7.502725