KLF14.H12INVIVO.0.PSM.A motif - HOmo sapiens COmprehensive MOdel COllection

Motif	KLF14.H12INVIVO.0.PSM.A
Gene (human)	KLF14 (GeneCards)
Gene synonyms (human)	BTEB5
Gene (mouse)	Klf14
Gene synonyms (mouse)
LOGO
LOGO (reverse complement)
Motif subtype	0
Quality	A

Motif length	14
Consensus	nddRKGGGCGTKdb
GC content	66.78%
Information content (bits; total / per base)	13.522 / 0.966
Data sources	ChIP-Seq + HT-SELEX + Methyl-HT-SELEX
Aligned words	8298

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Human	1 (6)	0.738	0.768	0.587	0.632	0.754	0.756	2.511	2.548	8.921	17.538

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 4 experiments	median	0.864	0.846	0.786	0.778	0.737	0.73
Overall, 4 experiments	best	0.987	0.977	0.979	0.966	0.957	0.939
Methyl HT-SELEX, 1 experiments	median	0.965	0.939	0.949	0.92	0.914	0.881
Methyl HT-SELEX, 1 experiments	best	0.965	0.939	0.949	0.92	0.914	0.881
Non-Methyl HT-SELEX, 3 experiments	median	0.763	0.753	0.623	0.636	0.559	0.578
Non-Methyl HT-SELEX, 3 experiments	best	0.987	0.977	0.979	0.966	0.957	0.939

rSNP benchmarking, SNP-SELEX	auROC	auPRC	Pearson r	Kendall tau
batch 2	0.62	0.057	0.243	0.167

TF superclass	Zinc-coordinating DNA-binding domains {2} (TFClass)
TF class	C2H2 zinc finger factors {2.3} (TFClass)
TF family	Three-zinc finger Kruppel-related {2.3.1} (TFClass)
TF subfamily	Kr-like {2.3.1.2} (TFClass)
TFClass ID	TFClass: 2.3.1.2.14
HGNC	HGNC:23025
MGI	MGI:3577024
EntrezGene (human)	GeneID:136259 (SSTAR profile)
EntrezGene (mouse)	GeneID:619665 (SSTAR profile)
UniProt ID (human)	KLF14_HUMAN
UniProt ID (mouse)	KLF14_MOUSE
UniProt AC (human)	Q8TD94 (TFClass)
UniProt AC (mouse)	Q19A41 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	1 human, 0 mouse
HT-SELEX	3
Methyl-HT-SELEX	1

PCM	KLF14.H12INVIVO.0.PSM.A.pcm
PWM	KLF14.H12INVIVO.0.PSM.A.pwm
PFM	KLF14.H12INVIVO.0.PSM.A.pfm
Alignment	KLF14.H12INVIVO.0.PSM.A.words.tsv
Threshold to P-value map	KLF14.H12INVIVO.0.PSM.A.thr
Motif in other formats
JASPAR format	KLF14.H12INVIVO.0.PSM.A_jaspar_format.txt
MEME format	KLF14.H12INVIVO.0.PSM.A_meme_format.meme
Transfac format	KLF14.H12INVIVO.0.PSM.A_transfac_format.txt
Homer format	KLF14.H12INVIVO.0.PSM.A_homer_format_0.001.txt KLF14.H12INVIVO.0.PSM.A_homer_format_0.0005.txt KLF14.H12INVIVO.0.PSM.A_homer_format_0.0001.txt

PCM

	A	C	G	T
01	2181.75	1310.75	2745.75	2059.75
02	2733.5	988.5	2665.5	1910.5
03	3051.0	692.0	3059.0	1496.0
04	1605.0	237.0	5839.0	617.0
05	624.0	106.0	4462.0	3106.0
06	590.0	40.0	7559.0	109.0
07	21.0	26.0	8234.0	17.0
08	0.0	1.0	8295.0	2.0
09	33.0	8185.0	4.0	76.0
10	1.0	0.0	8295.0	2.0
11	75.0	76.0	730.0	7417.0
12	859.0	129.0	5663.0	1647.0
13	1090.5	640.5	3354.5	3212.5
14	1165.25	2740.25	1497.25	2895.25

PFM

	A	C	G	T
01	0.263	0.158	0.331	0.248
02	0.329	0.119	0.321	0.23
03	0.368	0.083	0.369	0.18
04	0.193	0.029	0.704	0.074
05	0.075	0.013	0.538	0.374
06	0.071	0.005	0.911	0.013
07	0.003	0.003	0.992	0.002
08	0.0	0.0	1.0	0.0
09	0.004	0.986	0.0	0.009
10	0.0	0.0	1.0	0.0
11	0.009	0.009	0.088	0.894
12	0.104	0.016	0.682	0.198
13	0.131	0.077	0.404	0.387
14	0.14	0.33	0.18	0.349

PWM

	A	C	G	T
01	0.05	-0.458	0.28	-0.007
02	0.276	-0.74	0.25	-0.082
03	0.385	-1.096	0.388	-0.327
04	-0.256	-2.161	1.034	-1.21
05	-1.199	-2.954	0.765	0.403
06	-1.255	-3.895	1.292	-2.927
07	-4.492	-4.297	1.378	-4.681
08	-6.825	-6.458	1.385	-6.19
09	-4.076	1.372	-5.805	-3.279
10	-6.458	-6.825	1.385	-6.19
11	-3.291	-3.279	-1.042	1.273
12	-0.88	-2.761	1.004	-0.23
13	-0.642	-1.173	0.48	0.437
14	-0.576	0.278	-0.326	0.333

Standard thresholds

P-value	Threshold
0.001	2.83816
0.0005	4.22986
0.0001	7.02266