KLF13.H12INVIVO.0.PSM.A motif - HOmo sapiens COmprehensive MOdel COllection

Motif	KLF13.H12INVIVO.0.PSM.A
Gene (human)	KLF13 (GeneCards)
Gene synonyms (human)	BTEB3, NSLP1
Gene (mouse)	Klf13
Gene synonyms (mouse)	Bteb3, Fklf2
LOGO
LOGO (reverse complement)
Motif subtype	0
Quality	A

Motif length	16
Consensus	vvRGKGGGMGKKKYbb
GC content	71.92%
Information content (bits; total / per base)	13.549 / 0.847
Data sources	ChIP-Seq + HT-SELEX + Methyl-HT-SELEX
Aligned words	383

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Human	2 (13)	0.769	0.88	0.635	0.78	0.796	0.894	2.944	3.888	39.569	169.229

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 6 experiments	median	0.982	0.971	0.966	0.949	0.932	0.909
Overall, 6 experiments	best	0.991	0.986	0.986	0.977	0.973	0.961
Methyl HT-SELEX, 2 experiments	median	0.982	0.971	0.967	0.95	0.936	0.913
Methyl HT-SELEX, 2 experiments	best	0.984	0.973	0.971	0.955	0.943	0.921
Non-Methyl HT-SELEX, 4 experiments	median	0.96	0.937	0.91	0.888	0.806	0.806
Non-Methyl HT-SELEX, 4 experiments	best	0.991	0.986	0.986	0.977	0.973	0.961

rSNP benchmarking, SNP-SELEX	auROC	auPRC	Pearson r	Kendall tau
batch 1	0.978	0.503	0.917	0.507
batch 2	0.889	0.53	0.832	0.621

TF superclass	Zinc-coordinating DNA-binding domains {2} (TFClass)
TF class	C2H2 zinc finger factors {2.3} (TFClass)
TF family	Three-zinc finger Kruppel-related {2.3.1} (TFClass)
TF subfamily	Kr-like {2.3.1.2} (TFClass)
TFClass ID	TFClass: 2.3.1.2.13
HGNC	HGNC:13672
MGI	MGI:1354948
EntrezGene (human)	GeneID:51621 (SSTAR profile)
EntrezGene (mouse)	GeneID:50794 (SSTAR profile)
UniProt ID (human)	KLF13_HUMAN
UniProt ID (mouse)	KLF13_MOUSE
UniProt AC (human)	Q9Y2Y9 (TFClass)
UniProt AC (mouse)	Q9JJZ6 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	2 human, 0 mouse
HT-SELEX	4
Methyl-HT-SELEX	2

PCM	KLF13.H12INVIVO.0.PSM.A.pcm
PWM	KLF13.H12INVIVO.0.PSM.A.pwm
PFM	KLF13.H12INVIVO.0.PSM.A.pfm
Alignment	KLF13.H12INVIVO.0.PSM.A.words.tsv
Threshold to P-value map	KLF13.H12INVIVO.0.PSM.A.thr
Motif in other formats
JASPAR format	KLF13.H12INVIVO.0.PSM.A_jaspar_format.txt
MEME format	KLF13.H12INVIVO.0.PSM.A_meme_format.meme
Transfac format	KLF13.H12INVIVO.0.PSM.A_transfac_format.txt
Homer format	KLF13.H12INVIVO.0.PSM.A_homer_format_0.001.txt KLF13.H12INVIVO.0.PSM.A_homer_format_0.0005.txt KLF13.H12INVIVO.0.PSM.A_homer_format_0.0001.txt

PCM

	A	C	G	T
01	50.0	122.0	176.0	35.0
02	187.0	57.0	116.0	23.0
03	231.0	32.0	100.0	20.0
04	65.0	6.0	301.0	11.0
05	82.0	2.0	199.0	100.0
06	19.0	0.0	303.0	61.0
07	6.0	3.0	374.0	0.0
08	3.0	0.0	380.0	0.0
09	76.0	267.0	0.0	40.0
10	5.0	3.0	374.0	1.0
11	3.0	5.0	162.0	213.0
12	29.0	36.0	263.0	55.0
13	46.0	26.0	245.0	66.0
14	10.0	294.0	32.0	47.0
15	42.0	136.0	73.0	132.0
16	24.0	170.0	150.0	39.0

PFM

	A	C	G	T
01	0.131	0.319	0.46	0.091
02	0.488	0.149	0.303	0.06
03	0.603	0.084	0.261	0.052
04	0.17	0.016	0.786	0.029
05	0.214	0.005	0.52	0.261
06	0.05	0.0	0.791	0.159
07	0.016	0.008	0.977	0.0
08	0.008	0.0	0.992	0.0
09	0.198	0.697	0.0	0.104
10	0.013	0.008	0.977	0.003
11	0.008	0.013	0.423	0.556
12	0.076	0.094	0.687	0.144
13	0.12	0.068	0.64	0.172
14	0.026	0.768	0.084	0.123
15	0.11	0.355	0.191	0.345
16	0.063	0.444	0.392	0.102

PWM

	A	C	G	T
01	-0.636	0.239	0.602	-0.98
02	0.662	-0.508	0.189	-1.379
03	0.872	-1.066	0.043	-1.51
04	-0.38	-2.564	1.135	-2.052
05	-0.152	-3.328	0.724	0.043
06	-1.557	-4.18	1.141	-0.442
07	-2.564	-3.076	1.351	-4.18
08	-3.076	-4.18	1.367	-4.18
09	-0.227	1.016	-4.18	-0.852
10	-2.707	-3.076	1.351	-3.666
11	-3.076	-2.707	0.52	0.791
12	-1.16	-0.953	1.001	-0.543
13	-0.717	-1.263	0.93	-0.365
14	-2.136	1.111	-1.066	-0.696
15	-0.805	0.346	-0.267	0.317
16	-1.339	0.567	0.443	-0.876

Standard thresholds

P-value	Threshold
0.001	3.75546
0.0005	4.82546
0.0001	7.01841