KLF12.H12CORE.0.P.C motif - HOmo sapiens COmprehensive MOdel COllection

Motif	KLF12.H12CORE.0.P.C
Gene (human)	KLF12 (GeneCards)
Gene synonyms (human)	AP2REP
Gene (mouse)	Klf12
Gene synonyms (mouse)	Ap2rep
LOGO
LOGO (reverse complement)
Motif subtype	0
Quality	C

Motif length	18
Consensus	dGGGCGGGGCbdRRvvbv
GC content	81.07%
Information content (bits; total / per base)	16.48 / 0.916
Data sources	ChIP-Seq
Aligned words	934

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Human	1 (5)	0.829	0.844	0.703	0.723	0.853	0.873	3.818	3.901	114.721	140.721

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 4 experiments	median	0.663	0.624	0.618	0.593	0.569	0.562
Overall, 4 experiments	best	0.917	0.865	0.89	0.837	0.816	0.777
Methyl HT-SELEX, 1 experiments	median	0.917	0.865	0.89	0.837	0.816	0.777
Methyl HT-SELEX, 1 experiments	best	0.917	0.865	0.89	0.837	0.816	0.777
Non-Methyl HT-SELEX, 3 experiments	median	0.542	0.54	0.515	0.519	0.503	0.51
Non-Methyl HT-SELEX, 3 experiments	best	0.783	0.709	0.722	0.667	0.634	0.615

rSNP benchmarking, SNP-SELEX	auROC	auPRC	Pearson r	Kendall tau
batch 1	0.739	0.136	0.824	0.525
batch 2	0.675	0.104	0.349	0.231

TF superclass	Zinc-coordinating DNA-binding domains {2} (TFClass)
TF class	C2H2 zinc finger factors {2.3} (TFClass)
TF family	Three-zinc finger Kruppel-related {2.3.1} (TFClass)
TF subfamily	Kr-like {2.3.1.2} (TFClass)
TFClass ID	TFClass: 2.3.1.2.12
HGNC	HGNC:6346
MGI	MGI:1333796
EntrezGene (human)	GeneID:11278 (SSTAR profile)
EntrezGene (mouse)	GeneID:16597 (SSTAR profile)
UniProt ID (human)	KLF12_HUMAN
UniProt ID (mouse)	KLF12_MOUSE
UniProt AC (human)	Q9Y4X4 (TFClass)
UniProt AC (mouse)	O35738 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	1 human, 0 mouse
HT-SELEX	3
Methyl-HT-SELEX	1

PCM	KLF12.H12CORE.0.P.C.pcm
PWM	KLF12.H12CORE.0.P.C.pwm
PFM	KLF12.H12CORE.0.P.C.pfm
Alignment	KLF12.H12CORE.0.P.C.words.tsv
Threshold to P-value map	KLF12.H12CORE.0.P.C.thr
Motif in other formats
JASPAR format	KLF12.H12CORE.0.P.C_jaspar_format.txt
MEME format	KLF12.H12CORE.0.P.C_meme_format.meme
Transfac format	KLF12.H12CORE.0.P.C_transfac_format.txt
Homer format	KLF12.H12CORE.0.P.C_homer_format_0.001.txt KLF12.H12CORE.0.P.C_homer_format_0.0005.txt KLF12.H12CORE.0.P.C_homer_format_0.0001.txt

PCM

	A	C	G	T
01	209.0	42.0	491.0	192.0
02	95.0	2.0	829.0	8.0
03	4.0	2.0	927.0	1.0
04	4.0	2.0	926.0	2.0
05	133.0	745.0	1.0	55.0
06	19.0	2.0	900.0	13.0
07	15.0	25.0	723.0	171.0
08	117.0	6.0	782.0	29.0
09	26.0	26.0	867.0	15.0
10	82.0	760.0	26.0	66.0
11	143.0	443.0	199.0	149.0
12	167.0	94.0	443.0	230.0
13	123.0	68.0	687.0	56.0
14	118.0	105.0	684.0	27.0
15	174.0	223.0	462.0	75.0
16	123.0	223.0	509.0	79.0
17	97.0	216.0	490.0	131.0
18	121.0	140.0	559.0	114.0

PFM

	A	C	G	T
01	0.224	0.045	0.526	0.206
02	0.102	0.002	0.888	0.009
03	0.004	0.002	0.993	0.001
04	0.004	0.002	0.991	0.002
05	0.142	0.798	0.001	0.059
06	0.02	0.002	0.964	0.014
07	0.016	0.027	0.774	0.183
08	0.125	0.006	0.837	0.031
09	0.028	0.028	0.928	0.016
10	0.088	0.814	0.028	0.071
11	0.153	0.474	0.213	0.16
12	0.179	0.101	0.474	0.246
13	0.132	0.073	0.736	0.06
14	0.126	0.112	0.732	0.029
15	0.186	0.239	0.495	0.08
16	0.132	0.239	0.545	0.085
17	0.104	0.231	0.525	0.14
18	0.13	0.15	0.599	0.122

PWM

	A	C	G	T
01	-0.11	-1.683	0.739	-0.194
02	-0.889	-4.149	1.262	-3.187
03	-3.718	-4.149	1.373	-4.464
04	-3.718	-4.149	1.372	-4.149
05	-0.557	1.155	-4.464	-1.423
06	-2.43	-4.149	1.344	-2.772
07	-2.644	-2.175	1.125	-0.309
08	-0.684	-3.418	1.204	-2.036
09	-2.139	-2.139	1.307	-2.644
10	-1.033	1.175	-2.139	-1.245
11	-0.486	0.637	-0.159	-0.445
12	-0.332	-0.899	0.637	-0.015
13	-0.634	-1.216	1.074	-1.405
14	-0.675	-0.79	1.07	-2.103
15	-0.292	-0.046	0.679	-1.12
16	-0.634	-0.046	0.775	-1.07
17	-0.868	-0.077	0.737	-0.572
18	-0.651	-0.507	0.869	-0.709

Standard thresholds

P-value	Threshold
0.001	2.41301
0.0005	3.64181
0.0001	6.20841