KLF11.H12INVIVO.1.SM.B motif - HOmo sapiens COmprehensive MOdel COllection

Motif	KLF11.H12INVIVO.1.SM.B
Gene (human)	KLF11 (GeneCards)
Gene synonyms (human)	FKLF, TIEG2
Gene (mouse)	Klf11
Gene synonyms (mouse)	Tieg2b, Tieg3
LOGO
LOGO (reverse complement)
Motif subtype	1
Quality	B

Motif length	26
Consensus	dddnRKGGGCGTGKbddRRGbSKbdb
GC content	69.14%
Information content (bits; total / per base)	18.987 / 0.73
Data sources	HT-SELEX + Methyl-HT-SELEX
Aligned words	2495

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Human	2 (14)	0.672	0.698	0.458	0.508	0.782	0.791	2.587	2.806	6.135	10.131

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 2 experiments	median	0.991	0.985	0.981	0.971	0.94	0.927
Overall, 2 experiments	best	0.992	0.986	0.981	0.972	0.946	0.931
Methyl HT-SELEX, 1 experiments	median	0.99	0.983	0.981	0.97	0.946	0.931
Methyl HT-SELEX, 1 experiments	best	0.99	0.983	0.981	0.97	0.946	0.931
Non-Methyl HT-SELEX, 1 experiments	median	0.992	0.986	0.981	0.972	0.934	0.922
Non-Methyl HT-SELEX, 1 experiments	best	0.992	0.986	0.981	0.972	0.934	0.922

rSNP benchmarking, SNP-SELEX	auROC	auPRC	Pearson r	Kendall tau
batch 2	0.846	0.59	0.81	0.563

TF superclass	Zinc-coordinating DNA-binding domains {2} (TFClass)
TF class	C2H2 zinc finger factors {2.3} (TFClass)
TF family	Three-zinc finger Kruppel-related {2.3.1} (TFClass)
TF subfamily	Kr-like {2.3.1.2} (TFClass)
TFClass ID	TFClass: 2.3.1.2.11
HGNC	HGNC:11811
MGI	MGI:2653368
EntrezGene (human)	GeneID:8462 (SSTAR profile)
EntrezGene (mouse)	GeneID:194655 (SSTAR profile)
UniProt ID (human)	KLF11_HUMAN
UniProt ID (mouse)	KLF11_MOUSE
UniProt AC (human)	O14901 (TFClass)
UniProt AC (mouse)	Q8K1S5 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	2 human, 0 mouse
HT-SELEX	1
Methyl-HT-SELEX	1

PCM	KLF11.H12INVIVO.1.SM.B.pcm
PWM	KLF11.H12INVIVO.1.SM.B.pwm
PFM	KLF11.H12INVIVO.1.SM.B.pfm
Alignment	KLF11.H12INVIVO.1.SM.B.words.tsv
Threshold to P-value map	KLF11.H12INVIVO.1.SM.B.thr
Motif in other formats
JASPAR format	KLF11.H12INVIVO.1.SM.B_jaspar_format.txt
MEME format	KLF11.H12INVIVO.1.SM.B_meme_format.meme
Transfac format	KLF11.H12INVIVO.1.SM.B_transfac_format.txt
Homer format	KLF11.H12INVIVO.1.SM.B_homer_format_0.001.txt KLF11.H12INVIVO.1.SM.B_homer_format_0.0005.txt KLF11.H12INVIVO.1.SM.B_homer_format_0.0001.txt

PCM

	A	C	G	T
01	456.75	363.75	980.75	693.75
02	484.75	366.75	1059.75	583.75
03	547.0	294.0	1017.0	637.0
04	591.0	454.0	904.0	546.0
05	546.0	114.0	1603.0	232.0
06	447.0	37.0	1118.0	893.0
07	354.0	4.0	2115.0	22.0
08	8.0	4.0	2478.0	5.0
09	10.0	0.0	2483.0	2.0
10	45.0	2388.0	3.0	59.0
11	17.0	3.0	2466.0	9.0
12	18.0	16.0	140.0	2321.0
13	94.0	42.0	2297.0	62.0
14	359.0	83.0	1284.0	769.0
15	387.0	995.0	704.0	409.0
16	606.0	317.0	1199.0	373.0
17	457.0	164.0	1068.0	806.0
18	416.0	132.0	1611.0	336.0
19	234.0	105.0	1967.0	189.0
20	179.0	103.0	2047.0	166.0
21	195.0	1164.0	902.0	234.0
22	164.0	553.0	1607.0	171.0
23	152.0	142.0	1012.0	1189.0
24	206.0	263.0	1434.0	592.0
25	319.75	274.75	1359.75	540.75
26	369.5	628.5	983.5	513.5

PFM

	A	C	G	T
01	0.183	0.146	0.393	0.278
02	0.194	0.147	0.425	0.234
03	0.219	0.118	0.408	0.255
04	0.237	0.182	0.362	0.219
05	0.219	0.046	0.642	0.093
06	0.179	0.015	0.448	0.358
07	0.142	0.002	0.848	0.009
08	0.003	0.002	0.993	0.002
09	0.004	0.0	0.995	0.001
10	0.018	0.957	0.001	0.024
11	0.007	0.001	0.988	0.004
12	0.007	0.006	0.056	0.93
13	0.038	0.017	0.921	0.025
14	0.144	0.033	0.515	0.308
15	0.155	0.399	0.282	0.164
16	0.243	0.127	0.481	0.149
17	0.183	0.066	0.428	0.323
18	0.167	0.053	0.646	0.135
19	0.094	0.042	0.788	0.076
20	0.072	0.041	0.82	0.067
21	0.078	0.467	0.362	0.094
22	0.066	0.222	0.644	0.069
23	0.061	0.057	0.406	0.477
24	0.083	0.105	0.575	0.237
25	0.128	0.11	0.545	0.217
26	0.148	0.252	0.394	0.206

PWM

	A	C	G	T
01	-0.31	-0.537	0.451	0.106
02	-0.251	-0.529	0.529	-0.066
03	-0.131	-0.749	0.488	0.021
04	-0.054	-0.316	0.37	-0.133
05	-0.133	-1.686	0.942	-0.984
06	-0.332	-2.776	0.582	0.358
07	-0.564	-4.655	1.219	-3.263
08	-4.141	-4.655	1.377	-4.499
09	-3.958	-5.768	1.379	-5.064
10	-2.59	1.34	-4.838	-2.329
11	-3.497	-4.838	1.372	-4.045
12	-3.445	-3.551	-1.483	1.312
13	-1.875	-2.656	1.301	-2.281
14	-0.55	-1.997	0.72	0.209
15	-0.475	0.466	0.121	-0.42
16	-0.029	-0.674	0.652	-0.512
17	-0.31	-1.327	0.536	0.256
18	-0.404	-1.541	0.947	-0.616
19	-0.975	-1.766	1.146	-1.187
20	-1.241	-1.785	1.186	-1.315
21	-1.156	0.622	0.368	-0.975
22	-1.327	-0.12	0.944	-1.286
23	-1.402	-1.469	0.483	0.644
24	-1.102	-0.859	0.831	-0.052
25	-0.665	-0.816	0.778	-0.142
26	-0.521	0.008	0.454	-0.194

Standard thresholds

P-value	Threshold
0.001	0.81486
0.0005	2.22911
0.0001	5.19246