KLF10.H12RSNP.1.PSM.A motif - HOmo sapiens COmprehensive MOdel COllection

Motif	KLF10.H12RSNP.1.PSM.A
Gene (human)	KLF10 (GeneCards)
Gene synonyms (human)	TIEG, TIEG1
Gene (mouse)	Klf10
Gene synonyms (mouse)	Gdnfif, Tieg, Tieg1
LOGO
LOGO (reverse complement)
Motif subtype	1
Quality	A

Motif length	26
Consensus	ddddRKGGGCGTGdvRKGGGYGTGdb
GC content	71.26%
Information content (bits; total / per base)	26.049 / 1.002
Data sources	ChIP-Seq + HT-SELEX + Methyl-HT-SELEX
Aligned words	6221

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Human	1 (7)	0.743	0.782	0.619	0.695	0.795	0.864	3.489	4.404	25.237	30.229

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 2 experiments	median	0.998	0.997	0.986	0.984	0.837	0.866
Overall, 2 experiments	best	0.999	0.999	0.997	0.996	0.922	0.927
Methyl HT-SELEX, 1 experiments	median	0.999	0.999	0.997	0.996	0.922	0.927
Methyl HT-SELEX, 1 experiments	best	0.999	0.999	0.997	0.996	0.922	0.927
Non-Methyl HT-SELEX, 1 experiments	median	0.997	0.996	0.976	0.972	0.753	0.805
Non-Methyl HT-SELEX, 1 experiments	best	0.997	0.996	0.976	0.972	0.753	0.805

rSNP benchmarking, SNP-SELEX	auROC	auPRC	Pearson r	Kendall tau
batch 1	0.857	0.275	0.837	0.571
batch 2	0.627	0.234	0.621	0.355

TF superclass	Zinc-coordinating DNA-binding domains {2} (TFClass)
TF class	C2H2 zinc finger factors {2.3} (TFClass)
TF family	Three-zinc finger Kruppel-related {2.3.1} (TFClass)
TF subfamily	Kr-like {2.3.1.2} (TFClass)
TFClass ID	TFClass: 2.3.1.2.10
HGNC	HGNC:11810
MGI	MGI:1101353
EntrezGene (human)	GeneID:7071 (SSTAR profile)
EntrezGene (mouse)	GeneID:21847 (SSTAR profile)
UniProt ID (human)	KLF10_HUMAN
UniProt ID (mouse)	KLF10_MOUSE
UniProt AC (human)	Q13118 (TFClass)
UniProt AC (mouse)	O89091 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	1 human, 0 mouse
HT-SELEX	1
Methyl-HT-SELEX	1

PCM	KLF10.H12RSNP.1.PSM.A.pcm
PWM	KLF10.H12RSNP.1.PSM.A.pwm
PFM	KLF10.H12RSNP.1.PSM.A.pfm
Alignment	KLF10.H12RSNP.1.PSM.A.words.tsv
Threshold to P-value map	KLF10.H12RSNP.1.PSM.A.thr
Motif in other formats
JASPAR format	KLF10.H12RSNP.1.PSM.A_jaspar_format.txt
MEME format	KLF10.H12RSNP.1.PSM.A_meme_format.meme
Transfac format	KLF10.H12RSNP.1.PSM.A_transfac_format.txt
Homer format	KLF10.H12RSNP.1.PSM.A_homer_format_0.001.txt KLF10.H12RSNP.1.PSM.A_homer_format_0.0005.txt KLF10.H12RSNP.1.PSM.A_homer_format_0.0001.txt

PCM

	A	C	G	T
01	1141.5	909.5	2433.5	1736.5
02	1107.75	926.75	2545.75	1640.75
03	1226.0	781.0	2512.0	1702.0
04	1399.0	950.0	2492.0	1380.0
05	1390.0	251.0	4146.0	434.0
06	1108.0	77.0	3708.0	1328.0
07	999.0	13.0	5163.0	46.0
08	2.0	2.0	6205.0	12.0
09	1.0	0.0	6216.0	4.0
10	39.0	5331.0	4.0	847.0
11	11.0	0.0	6198.0	12.0
12	25.0	49.0	205.0	5942.0
13	117.0	39.0	5997.0	68.0
14	886.0	166.0	2675.0	2494.0
15	782.0	2995.0	1701.0	743.0
16	1661.0	341.0	3677.0	542.0
17	936.0	152.0	3520.0	1613.0
18	966.0	11.0	5200.0	44.0
19	12.0	4.0	6201.0	4.0
20	10.0	6.0	6202.0	3.0
21	84.0	4655.0	431.0	1051.0
22	38.0	306.0	5786.0	91.0
23	35.0	163.0	743.0	5280.0
24	106.0	168.0	5454.0	493.0
25	642.0	329.0	3000.0	2250.0
26	727.75	2466.75	1757.75	1268.75

PFM

	A	C	G	T
01	0.183	0.146	0.391	0.279
02	0.178	0.149	0.409	0.264
03	0.197	0.126	0.404	0.274
04	0.225	0.153	0.401	0.222
05	0.223	0.04	0.666	0.07
06	0.178	0.012	0.596	0.213
07	0.161	0.002	0.83	0.007
08	0.0	0.0	0.997	0.002
09	0.0	0.0	0.999	0.001
10	0.006	0.857	0.001	0.136
11	0.002	0.0	0.996	0.002
12	0.004	0.008	0.033	0.955
13	0.019	0.006	0.964	0.011
14	0.142	0.027	0.43	0.401
15	0.126	0.481	0.273	0.119
16	0.267	0.055	0.591	0.087
17	0.15	0.024	0.566	0.259
18	0.155	0.002	0.836	0.007
19	0.002	0.001	0.997	0.001
20	0.002	0.001	0.997	0.0
21	0.014	0.748	0.069	0.169
22	0.006	0.049	0.93	0.015
23	0.006	0.026	0.119	0.849
24	0.017	0.027	0.877	0.079
25	0.103	0.053	0.482	0.362
26	0.117	0.397	0.283	0.204

PWM

	A	C	G	T
01	-0.309	-0.536	0.447	0.11
02	-0.339	-0.517	0.492	0.053
03	-0.238	-0.687	0.479	0.09
04	-0.106	-0.492	0.471	-0.119
05	-0.112	-1.817	0.98	-1.273
06	-0.339	-2.979	0.868	-0.158
07	-0.442	-4.631	1.199	-3.476
08	-5.92	-5.92	1.383	-4.699
09	-6.193	-6.57	1.384	-5.529
10	-3.633	1.231	-5.529	-0.607
11	-4.772	-6.57	1.382	-4.699
12	-4.048	-3.415	-2.017	1.339
13	-2.57	-3.633	1.349	-3.1
14	-0.562	-2.226	0.542	0.472
15	-0.686	0.655	0.089	-0.737
16	0.066	-1.513	0.86	-1.052
17	-0.507	-2.313	0.816	0.036
18	-0.475	-4.772	1.206	-3.518
19	-4.699	-5.529	1.382	-5.529
20	-4.851	-5.249	1.382	-5.705
21	-2.894	1.095	-1.28	-0.391
22	-3.657	-1.62	1.313	-2.816
23	-3.735	-2.244	-0.737	1.221
24	-2.667	-2.214	1.254	-1.146
25	-0.883	-1.548	0.656	0.369
26	-0.758	0.461	0.122	-0.203

Standard thresholds

P-value	Threshold
0.001	-6.16289
0.0005	-4.16929
0.0001	0.05801