KLF10.H12INVIVO.1.PSM.A motif - HOmo sapiens COmprehensive MOdel COllection

Motif	KLF10.H12INVIVO.1.PSM.A
Gene (human)	KLF10 (GeneCards)
Gene synonyms (human)	TIEG, TIEG1
Gene (mouse)	Klf10
Gene synonyms (mouse)	Gdnfif, Tieg, Tieg1
LOGO
LOGO (reverse complement)
Motif subtype	1
Quality	A

Motif length	26
Consensus	dddnRKGGGCGTGKbddRGGSSKKdb
GC content	70.07%
Information content (bits; total / per base)	22.463 / 0.864
Data sources	ChIP-Seq + HT-SELEX + Methyl-HT-SELEX
Aligned words	9783

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Human	1 (7)	0.769	0.806	0.64	0.699	0.824	0.877	3.568	4.305	28.276	31.959

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 2 experiments	median	0.996	0.994	0.981	0.976	0.849	0.871
Overall, 2 experiments	best	0.998	0.997	0.994	0.992	0.937	0.936
Methyl HT-SELEX, 1 experiments	median	0.998	0.997	0.994	0.992	0.937	0.936
Methyl HT-SELEX, 1 experiments	best	0.998	0.997	0.994	0.992	0.937	0.936
Non-Methyl HT-SELEX, 1 experiments	median	0.994	0.99	0.969	0.961	0.762	0.806
Non-Methyl HT-SELEX, 1 experiments	best	0.994	0.99	0.969	0.961	0.762	0.806

rSNP benchmarking, SNP-SELEX	auROC	auPRC	Pearson r	Kendall tau
batch 1	0.853	0.038	0.861	0.643
batch 2	0.6	0.186	0.603	0.372

TF superclass	Zinc-coordinating DNA-binding domains {2} (TFClass)
TF class	C2H2 zinc finger factors {2.3} (TFClass)
TF family	Three-zinc finger Kruppel-related {2.3.1} (TFClass)
TF subfamily	Kr-like {2.3.1.2} (TFClass)
TFClass ID	TFClass: 2.3.1.2.10
HGNC	HGNC:11810
MGI	MGI:1101353
EntrezGene (human)	GeneID:7071 (SSTAR profile)
EntrezGene (mouse)	GeneID:21847 (SSTAR profile)
UniProt ID (human)	KLF10_HUMAN
UniProt ID (mouse)	KLF10_MOUSE
UniProt AC (human)	Q13118 (TFClass)
UniProt AC (mouse)	O89091 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	1 human, 0 mouse
HT-SELEX	1
Methyl-HT-SELEX	1

PCM	KLF10.H12INVIVO.1.PSM.A.pcm
PWM	KLF10.H12INVIVO.1.PSM.A.pwm
PFM	KLF10.H12INVIVO.1.PSM.A.pfm
Alignment	KLF10.H12INVIVO.1.PSM.A.words.tsv
Threshold to P-value map	KLF10.H12INVIVO.1.PSM.A.thr
Motif in other formats
JASPAR format	KLF10.H12INVIVO.1.PSM.A_jaspar_format.txt
MEME format	KLF10.H12INVIVO.1.PSM.A_meme_format.meme
Transfac format	KLF10.H12INVIVO.1.PSM.A_transfac_format.txt
Homer format	KLF10.H12INVIVO.1.PSM.A_homer_format_0.001.txt KLF10.H12INVIVO.1.PSM.A_homer_format_0.0005.txt KLF10.H12INVIVO.1.PSM.A_homer_format_0.0001.txt

PCM

	A	C	G	T
01	1734.75	1343.75	3694.75	3009.75
02	1767.5	1300.5	4226.5	2488.5
03	2109.0	1179.0	3876.0	2619.0
04	2315.0	1692.0	3771.0	2005.0
05	2325.0	386.0	6332.0	740.0
06	1776.0	130.0	5990.0	1887.0
07	1805.0	18.0	7896.0	64.0
08	0.0	14.0	9758.0	11.0
09	3.0	4.0	9774.0	2.0
10	68.0	8713.0	7.0	995.0
11	29.0	1.0	9741.0	12.0
12	32.0	55.0	283.0	9413.0
13	95.0	54.0	9562.0	72.0
14	1322.0	220.0	4035.0	4206.0
15	1058.0	5467.0	2198.0	1060.0
16	2915.0	809.0	4868.0	1191.0
17	1730.0	451.0	5194.0	2408.0
18	1716.0	208.0	7224.0	635.0
19	507.0	224.0	8648.0	404.0
20	322.0	233.0	8865.0	363.0
21	407.0	5851.0	2184.0	1341.0
22	355.0	1188.0	7704.0	536.0
23	328.0	477.0	2360.0	6618.0
24	353.0	414.0	7443.0	1573.0
25	984.5	583.5	4958.5	3256.5
26	1113.75	3530.75	3079.75	2058.75

PFM

	A	C	G	T
01	0.177	0.137	0.378	0.308
02	0.181	0.133	0.432	0.254
03	0.216	0.121	0.396	0.268
04	0.237	0.173	0.385	0.205
05	0.238	0.039	0.647	0.076
06	0.182	0.013	0.612	0.193
07	0.185	0.002	0.807	0.007
08	0.0	0.001	0.997	0.001
09	0.0	0.0	0.999	0.0
10	0.007	0.891	0.001	0.102
11	0.003	0.0	0.996	0.001
12	0.003	0.006	0.029	0.962
13	0.01	0.006	0.977	0.007
14	0.135	0.022	0.412	0.43
15	0.108	0.559	0.225	0.108
16	0.298	0.083	0.498	0.122
17	0.177	0.046	0.531	0.246
18	0.175	0.021	0.738	0.065
19	0.052	0.023	0.884	0.041
20	0.033	0.024	0.906	0.037
21	0.042	0.598	0.223	0.137
22	0.036	0.121	0.787	0.055
23	0.034	0.049	0.241	0.676
24	0.036	0.042	0.761	0.161
25	0.101	0.06	0.507	0.333
26	0.114	0.361	0.315	0.21

PWM

	A	C	G	T
01	-0.343	-0.598	0.412	0.207
02	-0.324	-0.631	0.547	0.017
03	-0.148	-0.729	0.46	0.068
04	-0.055	-0.368	0.433	-0.199
05	-0.051	-1.841	0.951	-1.193
06	-0.32	-2.918	0.895	-0.259
07	-0.303	-4.793	1.171	-3.609
08	-6.971	-5.012	1.383	-5.215
09	-6.136	-5.963	1.385	-6.345
10	-3.55	1.27	-5.573	-0.898
11	-4.36	-6.61	1.381	-5.143
12	-4.268	-3.755	-2.15	1.347
13	-3.225	-3.772	1.363	-3.495
14	-0.614	-2.399	0.5	0.542
15	-0.837	0.804	-0.107	-0.835
16	0.175	-1.104	0.688	-0.719
17	-0.346	-1.686	0.753	-0.016
18	-0.354	-2.455	1.082	-1.346
19	-1.57	-2.381	1.262	-1.796
20	-2.021	-2.342	1.287	-1.902
21	-1.789	0.872	-0.113	-0.6
22	-1.924	-0.721	1.147	-1.515
23	-2.003	-1.631	-0.036	0.995
24	-1.93	-1.772	1.112	-0.441
25	-0.909	-1.43	0.706	0.286
26	-0.785	0.367	0.23	-0.172

Standard thresholds

P-value	Threshold
0.001	-2.06139
0.0005	-0.35949
0.0001	3.20911