KLF10.H12INVITRO.1.PSM.A motif - HOmo sapiens COmprehensive MOdel COllection

Motif	KLF10.H12INVITRO.1.PSM.A
Gene (human)	KLF10 (GeneCards)
Gene synonyms (human)	TIEG, TIEG1
Gene (mouse)	Klf10
Gene synonyms (mouse)	Gdnfif, Tieg, Tieg1
LOGO
LOGO (reverse complement)
Motif subtype	1
Quality	A

Motif length	24
Consensus	ddRKGGGYGTGdvRKGGGYGTGdb
GC content	69.78%
Information content (bits; total / per base)	24.956 / 1.04
Data sources	ChIP-Seq + HT-SELEX + Methyl-HT-SELEX
Aligned words	7817

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Human	1 (7)	0.732	0.796	0.613	0.716	0.782	0.857	3.348	4.31	25.357	30.538

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 2 experiments	median	0.999	0.999	0.992	0.99	0.847	0.876
Overall, 2 experiments	best	0.999	0.999	0.998	0.997	0.926	0.932
Methyl HT-SELEX, 1 experiments	median	0.999	0.999	0.998	0.997	0.926	0.932
Methyl HT-SELEX, 1 experiments	best	0.999	0.999	0.998	0.997	0.926	0.932
Non-Methyl HT-SELEX, 1 experiments	median	0.999	0.998	0.986	0.984	0.768	0.82
Non-Methyl HT-SELEX, 1 experiments	best	0.999	0.998	0.986	0.984	0.768	0.82

rSNP benchmarking, SNP-SELEX	auROC	auPRC	Pearson r	Kendall tau
batch 1	0.824	0.267	0.821	0.643
batch 2	0.622	0.267	0.641	0.353

TF superclass	Zinc-coordinating DNA-binding domains {2} (TFClass)
TF class	C2H2 zinc finger factors {2.3} (TFClass)
TF family	Three-zinc finger Kruppel-related {2.3.1} (TFClass)
TF subfamily	Kr-like {2.3.1.2} (TFClass)
TFClass ID	TFClass: 2.3.1.2.10
HGNC	HGNC:11810
MGI	MGI:1101353
EntrezGene (human)	GeneID:7071 (SSTAR profile)
EntrezGene (mouse)	GeneID:21847 (SSTAR profile)
UniProt ID (human)	KLF10_HUMAN
UniProt ID (mouse)	KLF10_MOUSE
UniProt AC (human)	Q13118 (TFClass)
UniProt AC (mouse)	O89091 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	1 human, 0 mouse
HT-SELEX	1
Methyl-HT-SELEX	1

PCM	KLF10.H12INVITRO.1.PSM.A.pcm
PWM	KLF10.H12INVITRO.1.PSM.A.pwm
PFM	KLF10.H12INVITRO.1.PSM.A.pfm
Alignment	KLF10.H12INVITRO.1.PSM.A.words.tsv
Threshold to P-value map	KLF10.H12INVITRO.1.PSM.A.thr
Motif in other formats
JASPAR format	KLF10.H12INVITRO.1.PSM.A_jaspar_format.txt
MEME format	KLF10.H12INVITRO.1.PSM.A_meme_format.meme
Transfac format	KLF10.H12INVITRO.1.PSM.A_transfac_format.txt
Homer format	KLF10.H12INVITRO.1.PSM.A_homer_format_0.001.txt KLF10.H12INVITRO.1.PSM.A_homer_format_0.0005.txt KLF10.H12INVITRO.1.PSM.A_homer_format_0.0001.txt

PCM

	A	C	G	T
01	2262.75	1004.75	2979.75	1569.75
02	2448.25	1062.25	2706.25	1600.25
03	1913.0	188.0	5364.0	352.0
04	1120.0	49.0	4687.0	1961.0
05	708.0	4.0	7095.0	10.0
06	2.0	3.0	7795.0	17.0
07	0.0	0.0	7816.0	1.0
08	92.0	5227.0	16.0	2482.0
09	47.0	1.0	7699.0	70.0
10	13.0	202.0	449.0	7153.0
11	391.0	220.0	6547.0	659.0
12	1715.0	355.0	3247.0	2500.0
13	1447.0	3209.0	2295.0	866.0
14	2467.0	317.0	4557.0	476.0
15	1067.0	73.0	4388.0	2289.0
16	695.0	4.0	7111.0	7.0
17	2.0	1.0	7809.0	5.0
18	5.0	7.0	7801.0	4.0
19	104.0	4405.0	233.0	3075.0
20	74.0	60.0	7494.0	189.0
21	27.0	260.0	847.0	6683.0
22	463.0	154.0	6425.0	775.0
23	801.0	539.0	3110.0	3367.0
24	826.5	3072.5	2027.5	1890.5

PFM

	A	C	G	T
01	0.289	0.129	0.381	0.201
02	0.313	0.136	0.346	0.205
03	0.245	0.024	0.686	0.045
04	0.143	0.006	0.6	0.251
05	0.091	0.001	0.908	0.001
06	0.0	0.0	0.997	0.002
07	0.0	0.0	1.0	0.0
08	0.012	0.669	0.002	0.318
09	0.006	0.0	0.985	0.009
10	0.002	0.026	0.057	0.915
11	0.05	0.028	0.838	0.084
12	0.219	0.045	0.415	0.32
13	0.185	0.411	0.294	0.111
14	0.316	0.041	0.583	0.061
15	0.136	0.009	0.561	0.293
16	0.089	0.001	0.91	0.001
17	0.0	0.0	0.999	0.001
18	0.001	0.001	0.998	0.001
19	0.013	0.564	0.03	0.393
20	0.009	0.008	0.959	0.024
21	0.003	0.033	0.108	0.855
22	0.059	0.02	0.822	0.099
23	0.102	0.069	0.398	0.431
24	0.106	0.393	0.259	0.242

PWM

	A	C	G	T
01	0.146	-0.664	0.421	-0.219
02	0.225	-0.609	0.325	-0.2
03	-0.021	-2.331	1.009	-1.709
04	-0.556	-3.642	0.874	0.003
05	-1.013	-5.748	1.289	-5.074
06	-6.134	-5.922	1.383	-4.622
07	-6.772	-6.772	1.385	-6.403
08	-3.033	0.983	-4.675	0.239
09	-3.682	-6.403	1.37	-3.299
10	-4.855	-2.26	-1.467	1.297
11	-1.604	-2.175	1.208	-1.085
12	-0.13	-1.7	0.507	0.246
13	-0.3	0.496	0.161	-0.812
14	0.233	-1.813	0.846	-1.409
15	-0.604	-3.258	0.808	0.158
16	-1.032	-5.748	1.291	-5.355
17	-6.134	-6.403	1.384	-5.599
18	-5.599	-5.355	1.383	-5.748
19	-2.913	0.812	-2.118	0.453
20	-3.245	-3.448	1.343	-2.325
21	-4.203	-2.01	-0.835	1.229
22	-1.436	-2.528	1.189	-0.923
23	-0.89	-1.285	0.464	0.544
24	-0.859	0.452	0.037	-0.033

Standard thresholds

P-value	Threshold
0.001	-5.87014
0.0005	-3.83569
0.0001	0.45811