MotifITF2.H12INVITRO.0.S.B
Gene (human)TCF4
(GeneCards)
Gene synonyms (human)BHLHB19, ITF2, SEF2
Gene (mouse)Tcf4
Gene synonyms (mouse)Itf2, Sef2
LOGO
LOGO (reverse complement)
Motif subtype0
Quality
B
Motif length16
ConsensusnbdKKYGCAGGTGYdn
GC content58.24%
Information content (bits; total / per base)15.282 / 0.955
Data sourcesHT-SELEX
Aligned words270

ChIP-Seq benchmarking Num. of experiments (peaksets) auROC, median auROC, best auPRC, median auPRC, best pseudo-auROC, median pseudo-auROC, best pseudo-log-auROC, median pseudo-log-auROC, best Centrality, median Centrality, best
Human 8 (55) 0.852 0.899 0.674 0.743 0.773 0.88 2.152 3.196 83.796 171.77

HT-SELEX benchmarking auROC10 auPRC10 auROC25 auPRC25 auROC50 auPRC50
Overall, 6 experiments median 0.975 0.954 0.969 0.947 0.931 0.907
best 0.996 0.993 0.995 0.991 0.99 0.986
Methyl HT-SELEX, 1 experiments median 0.975 0.954 0.97 0.947 0.934 0.91
best 0.975 0.954 0.97 0.947 0.934 0.91
Non-Methyl HT-SELEX, 5 experiments median 0.975 0.955 0.969 0.947 0.927 0.904
best 0.996 0.993 0.995 0.991 0.99 0.986

rSNP benchmarking, ADASTRA odds-ratio -log-Fisher's P Pearson r Kendall tau
# 2.528 10.256 0.144 0.129
TF superclassBasic domains {1} (TFClass)
TF classBasic helix-loop-helix factors (bHLH) {1.2} (TFClass)
TF familyE2A {1.2.1} (TFClass)
TF subfamilyE2A-like {1.2.1.0} (TFClass)
TFClass IDTFClass: 1.2.1.0.2
HGNCHGNC:11634
MGIMGI:98506
EntrezGene (human)GeneID:6925
(SSTAR profile)
EntrezGene (mouse)GeneID:21413
(SSTAR profile)
UniProt ID (human)ITF2_HUMAN
UniProt ID (mouse)ITF2_MOUSE
UniProt AC (human)P15884
(TFClass)
UniProt AC (mouse)Q60722
(TFClass)
GRECO-DB-TF
yes
ChIP-Seq 8 human, 0 mouse
HT-SELEX 5
Methyl-HT-SELEX 1
PCM
ACGT
0180.7560.7579.7548.75
0223.75143.7557.7544.75
03146.015.066.043.0
0423.019.0142.086.0
0518.010.0177.065.0
0618.088.01.0163.0
0717.02.0251.00.0
080.0270.00.00.0
09270.00.00.00.0
100.0114.0156.00.0
110.0114.0156.00.0
120.00.00.0270.0
130.00.0270.00.0
140.086.011.0173.0
1537.032.072.0129.0
1660.062.060.088.0
PFM
ACGT
010.2990.2250.2950.181
020.0880.5320.2140.166
030.5410.0560.2440.159
040.0850.070.5260.319
050.0670.0370.6560.241
060.0670.3260.0040.604
070.0630.0070.930.0
080.01.00.00.0
091.00.00.00.0
100.00.4220.5780.0
110.00.4220.5780.0
120.00.00.01.0
130.00.01.00.0
140.00.3190.0410.641
150.1370.1190.2670.478
160.2220.230.2220.326
PWM
ACGT
010.176-0.1030.164-0.318
02-1.0080.745-0.153-0.401
030.76-1.435-0.022-0.439
04-1.038-1.2170.7330.238
05-1.267-1.7990.951-0.037
06-1.2670.26-3.3570.87
07-1.32-3.0091.298-3.896
08-3.8961.371-3.896-3.896
091.371-3.896-3.896-3.896
10-3.8960.5160.826-3.896
11-3.8960.5160.826-3.896
12-3.896-3.896-3.8961.371
13-3.896-3.8961.371-3.896
14-3.8960.238-1.7150.929
15-0.585-0.7240.0630.638
16-0.115-0.083-0.1150.26
Standard thresholds
P-value Threshold
0.001 2.66586
0.0005 3.96466
0.0001 6.59191