MotifISX.H12CORE.2.SM.B
Gene (human)ISX
(GeneCards)
Gene synonyms (human)RAXLX
Gene (mouse)Isx
Gene synonyms (mouse)
LOGO
LOGO (reverse complement)
Motif subtype2
Quality
B
Motif length17
ConsensusddbYMRYTAATTARbnn
GC content30.01%
Information content (bits; total / per base)15.452 / 0.909
Data sourcesHT-SELEX + Methyl-HT-SELEX
Aligned words697

HT-SELEX benchmarking auROC10 auPRC10 auROC25 auPRC25 auROC50 auPRC50
Overall, 8 experiments median 0.982 0.969 0.977 0.961 0.965 0.946
best 0.991 0.986 0.989 0.98 0.986 0.976
Methyl HT-SELEX, 2 experiments median 0.986 0.976 0.981 0.968 0.972 0.956
best 0.991 0.986 0.988 0.98 0.984 0.974
Non-Methyl HT-SELEX, 6 experiments median 0.98 0.966 0.968 0.95 0.893 0.887
best 0.991 0.984 0.989 0.98 0.986 0.976

rSNP benchmarking, SNP-SELEX auROC auPRC Pearson r Kendall tau
batch 1 0.905 0.606 0.865 0.515
batch 2 0.698 0.295 0.638 0.467
TF superclassHelix-turn-helix domains {3} (TFClass)
TF classHomeo domain factors {3.1} (TFClass)
TF familyPaired-related HD {3.1.3} (TFClass)
TF subfamilyISX {3.1.3.12} (TFClass)
TFClass IDTFClass: 3.1.3.12.1
HGNCHGNC:28084
MGIMGI:1918847
EntrezGene (human)GeneID:91464
(SSTAR profile)
EntrezGene (mouse)GeneID:71597
(SSTAR profile)
UniProt ID (human)ISX_HUMAN
UniProt ID (mouse)ISX_MOUSE
UniProt AC (human)Q2M1V0
(TFClass)
UniProt AC (mouse)A1A546
(TFClass)
GRECO-DB-TF
yes
ChIP-Seq 0 human, 0 mouse
HT-SELEX 6
Methyl-HT-SELEX 2
PCM
ACGT
01295.2598.25135.25168.25
02341.2596.25136.25123.25
03102.0103.0165.0327.0
0422.0145.0108.0422.0
05425.0141.0104.027.0
06450.060.0184.03.0
076.0203.017.0471.0
080.022.00.0675.0
09697.00.00.00.0
10697.00.00.00.0
110.00.00.0697.0
120.00.00.0697.0
13579.00.0118.00.0
14128.076.0493.00.0
15102.0324.0133.0138.0
16162.5205.5229.599.5
17205.0144.0115.0233.0
PFM
ACGT
010.4240.1410.1940.241
020.490.1380.1950.177
030.1460.1480.2370.469
040.0320.2080.1550.605
050.610.2020.1490.039
060.6460.0860.2640.004
070.0090.2910.0240.676
080.00.0320.00.968
091.00.00.00.0
101.00.00.00.0
110.00.00.01.0
120.00.00.01.0
130.8310.00.1690.0
140.1840.1090.7070.0
150.1460.4650.1910.198
160.2330.2950.3290.143
170.2940.2070.1650.334
PWM
ACGT
010.524-0.566-0.251-0.035
020.668-0.586-0.243-0.342
03-0.529-0.519-0.0540.625
04-2.007-0.182-0.4730.879
050.886-0.21-0.51-1.815
060.943-1.0490.054-3.636
07-3.1370.151-2.2450.988
08-4.677-2.007-4.6771.347
091.379-4.677-4.677-4.677
101.379-4.677-4.677-4.677
11-4.677-4.677-4.6771.379
12-4.677-4.677-4.6771.379
131.194-4.677-0.385-4.677
14-0.305-0.8181.034-4.677
15-0.5290.616-0.267-0.231
16-0.0690.1640.273-0.553
170.161-0.189-0.4110.288
Standard thresholds
P-value Threshold
0.001 1.96511
0.0005 3.35791
0.0001 6.35841