Motif | ISX.H12CORE.2.SM.B |
Gene (human) | ISX (GeneCards) |
Gene synonyms (human) | RAXLX |
Gene (mouse) | Isx |
Gene synonyms (mouse) | |
LOGO | |
LOGO (reverse complement) | |
Motif subtype | 2 |
Quality | B |
Motif | ISX.H12CORE.2.SM.B |
Gene (human) | ISX (GeneCards) |
Gene synonyms (human) | RAXLX |
Gene (mouse) | Isx |
Gene synonyms (mouse) | |
LOGO | |
LOGO (reverse complement) | |
Motif subtype | 2 |
Quality | B |
Motif length | 17 |
Consensus | ddbYMRYTAATTARbnn |
GC content | 30.01% |
Information content (bits; total / per base) | 15.452 / 0.909 |
Data sources | HT-SELEX + Methyl-HT-SELEX |
Aligned words | 697 |
HT-SELEX benchmarking | auROC10 | auPRC10 | auROC25 | auPRC25 | auROC50 | auPRC50 | |
---|---|---|---|---|---|---|---|
Overall, 8 experiments | median | 0.982 | 0.969 | 0.977 | 0.961 | 0.965 | 0.946 |
best | 0.991 | 0.986 | 0.989 | 0.98 | 0.986 | 0.976 | |
Methyl HT-SELEX, 2 experiments | median | 0.986 | 0.976 | 0.981 | 0.968 | 0.972 | 0.956 |
best | 0.991 | 0.986 | 0.988 | 0.98 | 0.984 | 0.974 | |
Non-Methyl HT-SELEX, 6 experiments | median | 0.98 | 0.966 | 0.968 | 0.95 | 0.893 | 0.887 |
best | 0.991 | 0.984 | 0.989 | 0.98 | 0.986 | 0.976 |
rSNP benchmarking, SNP-SELEX | auROC | auPRC | Pearson r | Kendall tau |
---|---|---|---|---|
batch 1 | 0.905 | 0.606 | 0.865 | 0.515 |
batch 2 | 0.698 | 0.295 | 0.638 | 0.467 |
TF superclass | Helix-turn-helix domains {3} (TFClass) |
TF class | Homeo domain factors {3.1} (TFClass) |
TF family | Paired-related HD {3.1.3} (TFClass) |
TF subfamily | ISX {3.1.3.12} (TFClass) |
TFClass ID | TFClass: 3.1.3.12.1 |
HGNC | HGNC:28084 |
MGI | MGI:1918847 |
EntrezGene (human) | GeneID:91464 (SSTAR profile) |
EntrezGene (mouse) | GeneID:71597 (SSTAR profile) |
UniProt ID (human) | ISX_HUMAN |
UniProt ID (mouse) | ISX_MOUSE |
UniProt AC (human) | Q2M1V0 (TFClass) |
UniProt AC (mouse) | A1A546 (TFClass) |
GRECO-DB-TF | yes |
ChIP-Seq | 0 human, 0 mouse |
HT-SELEX | 6 |
Methyl-HT-SELEX | 2 |
PCM | ISX.H12CORE.2.SM.B.pcm |
PWM | ISX.H12CORE.2.SM.B.pwm |
PFM | ISX.H12CORE.2.SM.B.pfm |
Alignment | ISX.H12CORE.2.SM.B.words.tsv |
Threshold to P-value map | ISX.H12CORE.2.SM.B.thr |
Motif in other formats | |
JASPAR format | ISX.H12CORE.2.SM.B_jaspar_format.txt |
MEME format | ISX.H12CORE.2.SM.B_meme_format.meme |
Transfac format | ISX.H12CORE.2.SM.B_transfac_format.txt |
Homer format |
A | C | G | T | |
---|---|---|---|---|
01 | 295.25 | 98.25 | 135.25 | 168.25 |
02 | 341.25 | 96.25 | 136.25 | 123.25 |
03 | 102.0 | 103.0 | 165.0 | 327.0 |
04 | 22.0 | 145.0 | 108.0 | 422.0 |
05 | 425.0 | 141.0 | 104.0 | 27.0 |
06 | 450.0 | 60.0 | 184.0 | 3.0 |
07 | 6.0 | 203.0 | 17.0 | 471.0 |
08 | 0.0 | 22.0 | 0.0 | 675.0 |
09 | 697.0 | 0.0 | 0.0 | 0.0 |
10 | 697.0 | 0.0 | 0.0 | 0.0 |
11 | 0.0 | 0.0 | 0.0 | 697.0 |
12 | 0.0 | 0.0 | 0.0 | 697.0 |
13 | 579.0 | 0.0 | 118.0 | 0.0 |
14 | 128.0 | 76.0 | 493.0 | 0.0 |
15 | 102.0 | 324.0 | 133.0 | 138.0 |
16 | 162.5 | 205.5 | 229.5 | 99.5 |
17 | 205.0 | 144.0 | 115.0 | 233.0 |
A | C | G | T | |
---|---|---|---|---|
01 | 0.424 | 0.141 | 0.194 | 0.241 |
02 | 0.49 | 0.138 | 0.195 | 0.177 |
03 | 0.146 | 0.148 | 0.237 | 0.469 |
04 | 0.032 | 0.208 | 0.155 | 0.605 |
05 | 0.61 | 0.202 | 0.149 | 0.039 |
06 | 0.646 | 0.086 | 0.264 | 0.004 |
07 | 0.009 | 0.291 | 0.024 | 0.676 |
08 | 0.0 | 0.032 | 0.0 | 0.968 |
09 | 1.0 | 0.0 | 0.0 | 0.0 |
10 | 1.0 | 0.0 | 0.0 | 0.0 |
11 | 0.0 | 0.0 | 0.0 | 1.0 |
12 | 0.0 | 0.0 | 0.0 | 1.0 |
13 | 0.831 | 0.0 | 0.169 | 0.0 |
14 | 0.184 | 0.109 | 0.707 | 0.0 |
15 | 0.146 | 0.465 | 0.191 | 0.198 |
16 | 0.233 | 0.295 | 0.329 | 0.143 |
17 | 0.294 | 0.207 | 0.165 | 0.334 |
A | C | G | T | |
---|---|---|---|---|
01 | 0.524 | -0.566 | -0.251 | -0.035 |
02 | 0.668 | -0.586 | -0.243 | -0.342 |
03 | -0.529 | -0.519 | -0.054 | 0.625 |
04 | -2.007 | -0.182 | -0.473 | 0.879 |
05 | 0.886 | -0.21 | -0.51 | -1.815 |
06 | 0.943 | -1.049 | 0.054 | -3.636 |
07 | -3.137 | 0.151 | -2.245 | 0.988 |
08 | -4.677 | -2.007 | -4.677 | 1.347 |
09 | 1.379 | -4.677 | -4.677 | -4.677 |
10 | 1.379 | -4.677 | -4.677 | -4.677 |
11 | -4.677 | -4.677 | -4.677 | 1.379 |
12 | -4.677 | -4.677 | -4.677 | 1.379 |
13 | 1.194 | -4.677 | -0.385 | -4.677 |
14 | -0.305 | -0.818 | 1.034 | -4.677 |
15 | -0.529 | 0.616 | -0.267 | -0.231 |
16 | -0.069 | 0.164 | 0.273 | -0.553 |
17 | 0.161 | -0.189 | -0.411 | 0.288 |
P-value | Threshold |
---|---|
0.001 | 1.96511 |
0.0005 | 3.35791 |
0.0001 | 6.35841 |