Motif | ISX.H12CORE.1.S.B |
Gene (human) | ISX (GeneCards) |
Gene synonyms (human) | RAXLX |
Gene (mouse) | Isx |
Gene synonyms (mouse) | |
LOGO | |
LOGO (reverse complement) | |
Motif subtype | 1 |
Quality | B |
Motif | ISX.H12CORE.1.S.B |
Gene (human) | ISX (GeneCards) |
Gene synonyms (human) | RAXLX |
Gene (mouse) | Isx |
Gene synonyms (mouse) | |
LOGO | |
LOGO (reverse complement) | |
Motif subtype | 1 |
Quality | B |
Motif length | 17 |
Consensus | nvbTAATTARhYWAdhd |
GC content | 25.4% |
Information content (bits; total / per base) | 16.507 / 0.971 |
Data sources | HT-SELEX |
Aligned words | 4776 |
HT-SELEX benchmarking | auROC10 | auPRC10 | auROC25 | auPRC25 | auROC50 | auPRC50 | |
---|---|---|---|---|---|---|---|
Overall, 8 experiments | median | 0.992 | 0.988 | 0.983 | 0.974 | 0.97 | 0.957 |
best | 0.999 | 0.998 | 0.996 | 0.995 | 0.99 | 0.986 | |
Methyl HT-SELEX, 2 experiments | median | 0.995 | 0.992 | 0.989 | 0.984 | 0.978 | 0.968 |
best | 0.999 | 0.998 | 0.996 | 0.995 | 0.99 | 0.986 | |
Non-Methyl HT-SELEX, 6 experiments | median | 0.992 | 0.988 | 0.975 | 0.965 | 0.891 | 0.894 |
best | 0.998 | 0.997 | 0.994 | 0.991 | 0.987 | 0.981 |
rSNP benchmarking, SNP-SELEX | auROC | auPRC | Pearson r | Kendall tau |
---|---|---|---|---|
batch 1 | 0.914 | 0.654 | 0.88 | 0.53 |
batch 2 | 0.731 | 0.321 | 0.761 | 0.572 |
TF superclass | Helix-turn-helix domains {3} (TFClass) |
TF class | Homeo domain factors {3.1} (TFClass) |
TF family | Paired-related HD {3.1.3} (TFClass) |
TF subfamily | ISX {3.1.3.12} (TFClass) |
TFClass ID | TFClass: 3.1.3.12.1 |
HGNC | HGNC:28084 |
MGI | MGI:1918847 |
EntrezGene (human) | GeneID:91464 (SSTAR profile) |
EntrezGene (mouse) | GeneID:71597 (SSTAR profile) |
UniProt ID (human) | ISX_HUMAN |
UniProt ID (mouse) | ISX_MOUSE |
UniProt AC (human) | Q2M1V0 (TFClass) |
UniProt AC (mouse) | A1A546 (TFClass) |
GRECO-DB-TF | yes |
ChIP-Seq | 0 human, 0 mouse |
HT-SELEX | 6 |
Methyl-HT-SELEX | 2 |
PCM | ISX.H12CORE.1.S.B.pcm |
PWM | ISX.H12CORE.1.S.B.pwm |
PFM | ISX.H12CORE.1.S.B.pfm |
Alignment | ISX.H12CORE.1.S.B.words.tsv |
Threshold to P-value map | ISX.H12CORE.1.S.B.thr |
Motif in other formats | |
JASPAR format | ISX.H12CORE.1.S.B_jaspar_format.txt |
MEME format | ISX.H12CORE.1.S.B_meme_format.meme |
Transfac format | ISX.H12CORE.1.S.B_transfac_format.txt |
Homer format |
A | C | G | T | |
---|---|---|---|---|
01 | 1454.75 | 1166.75 | 1150.75 | 1003.75 |
02 | 1221.5 | 632.5 | 2606.5 | 315.5 |
03 | 358.0 | 2228.0 | 693.0 | 1497.0 |
04 | 0.0 | 114.0 | 1.0 | 4661.0 |
05 | 4776.0 | 0.0 | 0.0 | 0.0 |
06 | 4776.0 | 0.0 | 0.0 | 0.0 |
07 | 0.0 | 0.0 | 0.0 | 4776.0 |
08 | 0.0 | 0.0 | 0.0 | 4776.0 |
09 | 3861.0 | 0.0 | 915.0 | 0.0 |
10 | 1118.0 | 178.0 | 3474.0 | 6.0 |
11 | 2825.0 | 934.0 | 408.0 | 609.0 |
12 | 301.0 | 640.0 | 330.0 | 3505.0 |
13 | 1054.0 | 322.0 | 141.0 | 3259.0 |
14 | 4139.0 | 184.0 | 82.0 | 371.0 |
15 | 2200.0 | 564.0 | 705.0 | 1307.0 |
16 | 783.25 | 1237.25 | 471.25 | 2284.25 |
17 | 1345.5 | 671.5 | 773.5 | 1985.5 |
A | C | G | T | |
---|---|---|---|---|
01 | 0.305 | 0.244 | 0.241 | 0.21 |
02 | 0.256 | 0.132 | 0.546 | 0.066 |
03 | 0.075 | 0.466 | 0.145 | 0.313 |
04 | 0.0 | 0.024 | 0.0 | 0.976 |
05 | 1.0 | 0.0 | 0.0 | 0.0 |
06 | 1.0 | 0.0 | 0.0 | 0.0 |
07 | 0.0 | 0.0 | 0.0 | 1.0 |
08 | 0.0 | 0.0 | 0.0 | 1.0 |
09 | 0.808 | 0.0 | 0.192 | 0.0 |
10 | 0.234 | 0.037 | 0.727 | 0.001 |
11 | 0.591 | 0.196 | 0.085 | 0.128 |
12 | 0.063 | 0.134 | 0.069 | 0.734 |
13 | 0.221 | 0.067 | 0.03 | 0.682 |
14 | 0.867 | 0.039 | 0.017 | 0.078 |
15 | 0.461 | 0.118 | 0.148 | 0.274 |
16 | 0.164 | 0.259 | 0.099 | 0.478 |
17 | 0.282 | 0.141 | 0.162 | 0.416 |
A | C | G | T | |
---|---|---|---|---|
01 | 0.197 | -0.023 | -0.037 | -0.173 |
02 | 0.023 | -0.634 | 0.78 | -1.326 |
03 | -1.2 | 0.623 | -0.543 | 0.226 |
04 | -6.336 | -2.332 | -5.95 | 1.361 |
05 | 1.385 | -6.336 | -6.336 | -6.336 |
06 | 1.385 | -6.336 | -6.336 | -6.336 |
07 | -6.336 | -6.336 | -6.336 | 1.385 |
08 | -6.336 | -6.336 | -6.336 | 1.385 |
09 | 1.172 | -6.336 | -0.266 | -6.336 |
10 | -0.066 | -1.893 | 1.067 | -4.993 |
11 | 0.86 | -0.245 | -1.07 | -0.672 |
12 | -1.373 | -0.622 | -1.281 | 1.076 |
13 | -0.124 | -1.306 | -2.123 | 1.003 |
14 | 1.242 | -1.86 | -2.655 | -1.165 |
15 | 0.61 | -0.748 | -0.526 | 0.09 |
16 | -0.421 | 0.036 | -0.927 | 0.648 |
17 | 0.119 | -0.574 | -0.433 | 0.508 |
P-value | Threshold |
---|---|
0.001 | 0.18686 |
0.0005 | 1.93311 |
0.0001 | 5.71296 |