Motif | ISX.H12CORE.0.SM.B |
Gene (human) | ISX (GeneCards) |
Gene synonyms (human) | RAXLX |
Gene (mouse) | Isx |
Gene synonyms (mouse) | |
LOGO | |
LOGO (reverse complement) | |
Motif subtype | 0 |
Quality | B |
Motif | ISX.H12CORE.0.SM.B |
Gene (human) | ISX (GeneCards) |
Gene synonyms (human) | RAXLX |
Gene (mouse) | Isx |
Gene synonyms (mouse) | |
LOGO | |
LOGO (reverse complement) | |
Motif subtype | 0 |
Quality | B |
Motif length | 12 |
Consensus | nvbTAATTGRnn |
GC content | 34.0% |
Information content (bits; total / per base) | 12.194 / 1.016 |
Data sources | HT-SELEX + Methyl-HT-SELEX |
Aligned words | 7723 |
HT-SELEX benchmarking | auROC10 | auPRC10 | auROC25 | auPRC25 | auROC50 | auPRC50 | |
---|---|---|---|---|---|---|---|
Overall, 8 experiments | median | 0.988 | 0.978 | 0.984 | 0.972 | 0.974 | 0.959 |
best | 0.995 | 0.992 | 0.994 | 0.99 | 0.991 | 0.985 | |
Methyl HT-SELEX, 2 experiments | median | 0.991 | 0.983 | 0.987 | 0.978 | 0.979 | 0.968 |
best | 0.995 | 0.991 | 0.994 | 0.989 | 0.99 | 0.984 | |
Non-Methyl HT-SELEX, 6 experiments | median | 0.987 | 0.976 | 0.977 | 0.963 | 0.902 | 0.901 |
best | 0.995 | 0.992 | 0.994 | 0.99 | 0.991 | 0.985 |
rSNP benchmarking, SNP-SELEX | auROC | auPRC | Pearson r | Kendall tau |
---|---|---|---|---|
batch 1 | 0.964 | 0.75 | 0.932 | 0.549 |
batch 2 | 0.742 | 0.333 | 0.748 | 0.561 |
TF superclass | Helix-turn-helix domains {3} (TFClass) |
TF class | Homeo domain factors {3.1} (TFClass) |
TF family | Paired-related HD {3.1.3} (TFClass) |
TF subfamily | ISX {3.1.3.12} (TFClass) |
TFClass ID | TFClass: 3.1.3.12.1 |
HGNC | HGNC:28084 |
MGI | MGI:1918847 |
EntrezGene (human) | GeneID:91464 (SSTAR profile) |
EntrezGene (mouse) | GeneID:71597 (SSTAR profile) |
UniProt ID (human) | ISX_HUMAN |
UniProt ID (mouse) | ISX_MOUSE |
UniProt AC (human) | Q2M1V0 (TFClass) |
UniProt AC (mouse) | A1A546 (TFClass) |
GRECO-DB-TF | yes |
ChIP-Seq | 0 human, 0 mouse |
HT-SELEX | 6 |
Methyl-HT-SELEX | 2 |
PCM | ISX.H12CORE.0.SM.B.pcm |
PWM | ISX.H12CORE.0.SM.B.pwm |
PFM | ISX.H12CORE.0.SM.B.pfm |
Alignment | ISX.H12CORE.0.SM.B.words.tsv |
Threshold to P-value map | ISX.H12CORE.0.SM.B.thr |
Motif in other formats | |
JASPAR format | ISX.H12CORE.0.SM.B_jaspar_format.txt |
MEME format | ISX.H12CORE.0.SM.B_meme_format.meme |
Transfac format | ISX.H12CORE.0.SM.B_transfac_format.txt |
Homer format |
A | C | G | T | |
---|---|---|---|---|
01 | 1944.0 | 1799.0 | 2353.0 | 1627.0 |
02 | 1707.0 | 1316.0 | 3623.0 | 1077.0 |
03 | 245.0 | 2801.0 | 1979.0 | 2698.0 |
04 | 0.0 | 2.0 | 0.0 | 7721.0 |
05 | 7723.0 | 0.0 | 0.0 | 0.0 |
06 | 7723.0 | 0.0 | 0.0 | 0.0 |
07 | 0.0 | 0.0 | 0.0 | 7723.0 |
08 | 0.0 | 0.0 | 0.0 | 7723.0 |
09 | 2816.0 | 0.0 | 4907.0 | 0.0 |
10 | 1403.0 | 861.0 | 5030.0 | 429.0 |
11 | 1498.0 | 1643.0 | 1939.0 | 2643.0 |
12 | 1410.25 | 1616.25 | 1637.25 | 3059.25 |
A | C | G | T | |
---|---|---|---|---|
01 | 0.252 | 0.233 | 0.305 | 0.211 |
02 | 0.221 | 0.17 | 0.469 | 0.139 |
03 | 0.032 | 0.363 | 0.256 | 0.349 |
04 | 0.0 | 0.0 | 0.0 | 1.0 |
05 | 1.0 | 0.0 | 0.0 | 0.0 |
06 | 1.0 | 0.0 | 0.0 | 0.0 |
07 | 0.0 | 0.0 | 0.0 | 1.0 |
08 | 0.0 | 0.0 | 0.0 | 1.0 |
09 | 0.365 | 0.0 | 0.635 | 0.0 |
10 | 0.182 | 0.111 | 0.651 | 0.056 |
11 | 0.194 | 0.213 | 0.251 | 0.342 |
12 | 0.183 | 0.209 | 0.212 | 0.396 |
A | C | G | T | |
---|---|---|---|---|
01 | 0.007 | -0.071 | 0.198 | -0.171 |
02 | -0.123 | -0.383 | 0.629 | -0.583 |
03 | -2.056 | 0.372 | 0.025 | 0.334 |
04 | -6.761 | -6.123 | -6.761 | 1.385 |
05 | 1.385 | -6.761 | -6.761 | -6.761 |
06 | 1.385 | -6.761 | -6.761 | -6.761 |
07 | -6.761 | -6.761 | -6.761 | 1.385 |
08 | -6.761 | -6.761 | -6.761 | 1.385 |
09 | 0.377 | -6.761 | 0.932 | -6.761 |
10 | -0.319 | -0.806 | 0.957 | -1.5 |
11 | -0.253 | -0.161 | 0.004 | 0.314 |
12 | -0.314 | -0.178 | -0.165 | 0.46 |
P-value | Threshold |
---|---|
0.001 | 0.824115 |
0.0005 | 2.334675 |
0.0001 | 7.926275 |