MotifISX.H12CORE.0.SM.B
Gene (human)ISX
(GeneCards)
Gene synonyms (human)RAXLX
Gene (mouse)Isx
Gene synonyms (mouse)
LOGO
LOGO (reverse complement)
Motif subtype0
Quality
B
Motif length12
ConsensusnvbTAATTGRnn
GC content34.0%
Information content (bits; total / per base)12.194 / 1.016
Data sourcesHT-SELEX + Methyl-HT-SELEX
Aligned words7723

HT-SELEX benchmarking auROC10 auPRC10 auROC25 auPRC25 auROC50 auPRC50
Overall, 8 experiments median 0.988 0.978 0.984 0.972 0.974 0.959
best 0.995 0.992 0.994 0.99 0.991 0.985
Methyl HT-SELEX, 2 experiments median 0.991 0.983 0.987 0.978 0.979 0.968
best 0.995 0.991 0.994 0.989 0.99 0.984
Non-Methyl HT-SELEX, 6 experiments median 0.987 0.976 0.977 0.963 0.902 0.901
best 0.995 0.992 0.994 0.99 0.991 0.985

rSNP benchmarking, SNP-SELEX auROC auPRC Pearson r Kendall tau
batch 1 0.964 0.75 0.932 0.549
batch 2 0.742 0.333 0.748 0.561
TF superclassHelix-turn-helix domains {3} (TFClass)
TF classHomeo domain factors {3.1} (TFClass)
TF familyPaired-related HD {3.1.3} (TFClass)
TF subfamilyISX {3.1.3.12} (TFClass)
TFClass IDTFClass: 3.1.3.12.1
HGNCHGNC:28084
MGIMGI:1918847
EntrezGene (human)GeneID:91464
(SSTAR profile)
EntrezGene (mouse)GeneID:71597
(SSTAR profile)
UniProt ID (human)ISX_HUMAN
UniProt ID (mouse)ISX_MOUSE
UniProt AC (human)Q2M1V0
(TFClass)
UniProt AC (mouse)A1A546
(TFClass)
GRECO-DB-TF
yes
ChIP-Seq 0 human, 0 mouse
HT-SELEX 6
Methyl-HT-SELEX 2
PCM
ACGT
011944.01799.02353.01627.0
021707.01316.03623.01077.0
03245.02801.01979.02698.0
040.02.00.07721.0
057723.00.00.00.0
067723.00.00.00.0
070.00.00.07723.0
080.00.00.07723.0
092816.00.04907.00.0
101403.0861.05030.0429.0
111498.01643.01939.02643.0
121410.251616.251637.253059.25
PFM
ACGT
010.2520.2330.3050.211
020.2210.170.4690.139
030.0320.3630.2560.349
040.00.00.01.0
051.00.00.00.0
061.00.00.00.0
070.00.00.01.0
080.00.00.01.0
090.3650.00.6350.0
100.1820.1110.6510.056
110.1940.2130.2510.342
120.1830.2090.2120.396
PWM
ACGT
010.007-0.0710.198-0.171
02-0.123-0.3830.629-0.583
03-2.0560.3720.0250.334
04-6.761-6.123-6.7611.385
051.385-6.761-6.761-6.761
061.385-6.761-6.761-6.761
07-6.761-6.761-6.7611.385
08-6.761-6.761-6.7611.385
090.377-6.7610.932-6.761
10-0.319-0.8060.957-1.5
11-0.253-0.1610.0040.314
12-0.314-0.178-0.1650.46
Standard thresholds
P-value Threshold
0.001 0.824115
0.0005 2.334675
0.0001 7.926275