| Motif | ISL2.H12CORE.0.SM.B |
| Gene (human) | ISL2 (GeneCards) |
| Gene synonyms (human) | |
| Gene (mouse) | Isl2 |
| Gene synonyms (mouse) | |
| LOGO |  |
| LOGO (reverse complement) |  |
| Motif subtype | 0 |
| Quality | B |
| Motif | ISL2.H12CORE.0.SM.B |
| Gene (human) | ISL2 (GeneCards) |
| Gene synonyms (human) | |
| Gene (mouse) | Isl2 |
| Gene synonyms (mouse) | |
| LOGO | |
| LOGO (reverse complement) | |
| Motif subtype | 0 |
| Quality | B |
| Motif length | 11 |
| Consensus | nvbTAATTRvn |
| GC content | 40.6% |
| Information content (bits; total / per base) | 9.542 / 0.867 |
| Data sources | HT-SELEX + Methyl-HT-SELEX |
| Aligned words | 9713 |
| HT-SELEX benchmarking | auROC10 | auPRC10 | auROC25 | auPRC25 | auROC50 | auPRC50 | |
|---|---|---|---|---|---|---|---|
| Overall, 4 experiments | median | 0.953 | 0.924 | 0.919 | 0.886 | 0.831 | 0.808 |
| best | 0.96 | 0.939 | 0.933 | 0.9 | 0.887 | 0.852 | |
| Methyl HT-SELEX, 1 experiments | median | 0.957 | 0.931 | 0.933 | 0.9 | 0.887 | 0.852 |
| best | 0.957 | 0.931 | 0.933 | 0.9 | 0.887 | 0.852 | |
| Non-Methyl HT-SELEX, 3 experiments | median | 0.949 | 0.917 | 0.914 | 0.885 | 0.798 | 0.787 |
| best | 0.96 | 0.939 | 0.924 | 0.886 | 0.864 | 0.829 | |
| TF superclass | Helix-turn-helix domains {3} (TFClass) |
| TF class | Homeo domain factors {3.1} (TFClass) |
| TF family | HD-LIM {3.1.5} (TFClass) |
| TF subfamily | ISL {3.1.5.1} (TFClass) |
| TFClass ID | TFClass: 3.1.5.1.2 |
| HGNC | HGNC:18524 |
| MGI | MGI:109156 |
| EntrezGene (human) | GeneID:64843 (SSTAR profile) |
| EntrezGene (mouse) | GeneID:104360 (SSTAR profile) |
| UniProt ID (human) | ISL2_HUMAN |
| UniProt ID (mouse) | ISL2_MOUSE |
| UniProt AC (human) | Q96A47 (TFClass) |
| UniProt AC (mouse) | Q9CXV0 (TFClass) |
| GRECO-DB-TF | yes |
| ChIP-Seq | 0 human, 0 mouse |
| HT-SELEX | 3 |
| Methyl-HT-SELEX | 1 |
| PCM | ISL2.H12CORE.0.SM.B.pcm |
| PWM | ISL2.H12CORE.0.SM.B.pwm |
| PFM | ISL2.H12CORE.0.SM.B.pfm |
| Alignment | ISL2.H12CORE.0.SM.B.words.tsv |
| Threshold to P-value map | ISL2.H12CORE.0.SM.B.thr |
| Motif in other formats | |
| JASPAR format | ISL2.H12CORE.0.SM.B_jaspar_format.txt |
| MEME format | ISL2.H12CORE.0.SM.B_meme_format.meme |
| Transfac format | ISL2.H12CORE.0.SM.B_transfac_format.txt |
| Homer format | |
| A | C | G | T | |
|---|---|---|---|---|
| 01 | 1954.75 | 3607.75 | 2310.75 | 1839.75 |
| 02 | 2862.5 | 2298.5 | 3618.5 | 933.5 |
| 03 | 556.0 | 3429.0 | 1468.0 | 4260.0 |
| 04 | 109.0 | 4.0 | 35.0 | 9565.0 |
| 05 | 9713.0 | 0.0 | 0.0 | 0.0 |
| 06 | 9712.0 | 1.0 | 0.0 | 0.0 |
| 07 | 0.0 | 0.0 | 4277.0 | 5436.0 |
| 08 | 17.0 | 3.0 | 3270.0 | 6423.0 |
| 09 | 1600.0 | 669.0 | 7333.0 | 111.0 |
| 10 | 2393.75 | 4243.75 | 2209.75 | 865.75 |
| 11 | 2439.5 | 2520.5 | 2078.5 | 2674.5 |
| A | C | G | T | |
|---|---|---|---|---|
| 01 | 0.201 | 0.371 | 0.238 | 0.189 |
| 02 | 0.295 | 0.237 | 0.373 | 0.096 |
| 03 | 0.057 | 0.353 | 0.151 | 0.439 |
| 04 | 0.011 | 0.0 | 0.004 | 0.985 |
| 05 | 1.0 | 0.0 | 0.0 | 0.0 |
| 06 | 1.0 | 0.0 | 0.0 | 0.0 |
| 07 | 0.0 | 0.0 | 0.44 | 0.56 |
| 08 | 0.002 | 0.0 | 0.337 | 0.661 |
| 09 | 0.165 | 0.069 | 0.755 | 0.011 |
| 10 | 0.246 | 0.437 | 0.228 | 0.089 |
| 11 | 0.251 | 0.259 | 0.214 | 0.275 |
| A | C | G | T | |
|---|---|---|---|---|
| 01 | -0.217 | 0.396 | -0.05 | -0.277 |
| 02 | 0.164 | -0.055 | 0.399 | -0.954 |
| 03 | -1.471 | 0.345 | -0.503 | 0.562 |
| 04 | -3.084 | -5.956 | -4.177 | 1.37 |
| 05 | 1.386 | -6.965 | -6.965 | -6.965 |
| 06 | 1.385 | -6.603 | -6.965 | -6.965 |
| 07 | -6.965 | -6.965 | 0.566 | 0.805 |
| 08 | -4.836 | -6.129 | 0.297 | 0.972 |
| 09 | -0.417 | -1.287 | 1.105 | -3.066 |
| 10 | -0.014 | 0.558 | -0.094 | -1.03 |
| 11 | 0.005 | 0.037 | -0.155 | 0.097 |
| P-value | Threshold |
|---|---|
| 0.001 | 5.363725 |
| 0.0005 | 6.233605 |
| 0.0001 | 7.503755 |