Motif | ISL1.H12CORE.0.PSM.A |
Gene (human) | ISL1 (GeneCards) |
Gene synonyms (human) | |
Gene (mouse) | Isl1 |
Gene synonyms (mouse) | |
LOGO | |
LOGO (reverse complement) | |
Motif subtype | 0 |
Quality | A |
Motif | ISL1.H12CORE.0.PSM.A |
Gene (human) | ISL1 (GeneCards) |
Gene synonyms (human) | |
Gene (mouse) | Isl1 |
Gene synonyms (mouse) | |
LOGO | |
LOGO (reverse complement) | |
Motif subtype | 0 |
Quality | A |
Motif length | 12 |
Consensus | nbvbTAATKRvn |
GC content | 41.28% |
Information content (bits; total / per base) | 9.668 / 0.806 |
Data sources | ChIP-Seq + HT-SELEX + Methyl-HT-SELEX |
Aligned words | 9875 |
ChIP-Seq benchmarking | Num. of experiments (peaksets) | auROC, median | auROC, best | auPRC, median | auPRC, best | pseudo-auROC, median | pseudo-auROC, best | pseudo-log-auROC, median | pseudo-log-auROC, best | Centrality, median | Centrality, best |
---|---|---|---|---|---|---|---|---|---|---|---|
Human | 2 (14) | 0.705 | 0.808 | 0.6 | 0.663 | 0.615 | 0.735 | 1.497 | 1.88 | 47.531 | 85.678 |
Mouse | 4 (16) | 0.833 | 0.854 | 0.726 | 0.763 | 0.745 | 0.767 | 1.994 | 2.122 | 101.968 | 131.509 |
HT-SELEX benchmarking | auROC10 | auPRC10 | auROC25 | auPRC25 | auROC50 | auPRC50 | |
---|---|---|---|---|---|---|---|
Overall, 4 experiments | median | 0.96 | 0.935 | 0.936 | 0.904 | 0.883 | 0.849 |
best | 0.976 | 0.961 | 0.959 | 0.937 | 0.917 | 0.892 | |
Methyl HT-SELEX, 2 experiments | median | 0.967 | 0.947 | 0.944 | 0.917 | 0.89 | 0.862 |
best | 0.976 | 0.961 | 0.959 | 0.937 | 0.917 | 0.892 | |
Non-Methyl HT-SELEX, 2 experiments | median | 0.958 | 0.932 | 0.934 | 0.901 | 0.883 | 0.849 |
best | 0.962 | 0.938 | 0.942 | 0.911 | 0.899 | 0.866 |
rSNP benchmarking, SNP-SELEX | auROC | auPRC | Pearson r | Kendall tau |
---|---|---|---|---|
batch 2 | 0.64 | 0.185 | 0.351 | 0.187 |
TF superclass | Helix-turn-helix domains {3} (TFClass) |
TF class | Homeo domain factors {3.1} (TFClass) |
TF family | HD-LIM {3.1.5} (TFClass) |
TF subfamily | ISL {3.1.5.1} (TFClass) |
TFClass ID | TFClass: 3.1.5.1.1 |
HGNC | HGNC:6132 |
MGI | MGI:101791 |
EntrezGene (human) | GeneID:3670 (SSTAR profile) |
EntrezGene (mouse) | GeneID:16392 (SSTAR profile) |
UniProt ID (human) | ISL1_HUMAN |
UniProt ID (mouse) | ISL1_MOUSE |
UniProt AC (human) | P61371 (TFClass) |
UniProt AC (mouse) | P61372 (TFClass) |
GRECO-DB-TF | yes |
ChIP-Seq | 2 human, 4 mouse |
HT-SELEX | 2 |
Methyl-HT-SELEX | 2 |
PCM | ISL1.H12CORE.0.PSM.A.pcm |
PWM | ISL1.H12CORE.0.PSM.A.pwm |
PFM | ISL1.H12CORE.0.PSM.A.pfm |
Alignment | ISL1.H12CORE.0.PSM.A.words.tsv |
Threshold to P-value map | ISL1.H12CORE.0.PSM.A.thr |
Motif in other formats | |
JASPAR format | ISL1.H12CORE.0.PSM.A_jaspar_format.txt |
MEME format | ISL1.H12CORE.0.PSM.A_meme_format.meme |
Transfac format | ISL1.H12CORE.0.PSM.A_transfac_format.txt |
Homer format |
A | C | G | T | |
---|---|---|---|---|
01 | 2348.25 | 1954.25 | 2926.25 | 2646.25 |
02 | 1639.5 | 4210.5 | 1976.5 | 2048.5 |
03 | 2776.0 | 2331.0 | 4136.0 | 632.0 |
04 | 472.0 | 4132.0 | 1256.0 | 4015.0 |
05 | 25.0 | 4.0 | 1.0 | 9845.0 |
06 | 9875.0 | 0.0 | 0.0 | 0.0 |
07 | 9875.0 | 0.0 | 0.0 | 0.0 |
08 | 0.0 | 0.0 | 2968.0 | 6907.0 |
09 | 14.0 | 41.0 | 4674.0 | 5146.0 |
10 | 1662.0 | 966.0 | 7039.0 | 208.0 |
11 | 3269.0 | 3427.0 | 2356.0 | 823.0 |
12 | 2577.75 | 2422.75 | 2091.75 | 2782.75 |
A | C | G | T | |
---|---|---|---|---|
01 | 0.238 | 0.198 | 0.296 | 0.268 |
02 | 0.166 | 0.426 | 0.2 | 0.207 |
03 | 0.281 | 0.236 | 0.419 | 0.064 |
04 | 0.048 | 0.418 | 0.127 | 0.407 |
05 | 0.003 | 0.0 | 0.0 | 0.997 |
06 | 1.0 | 0.0 | 0.0 | 0.0 |
07 | 1.0 | 0.0 | 0.0 | 0.0 |
08 | 0.0 | 0.0 | 0.301 | 0.699 |
09 | 0.001 | 0.004 | 0.473 | 0.521 |
10 | 0.168 | 0.098 | 0.713 | 0.021 |
11 | 0.331 | 0.347 | 0.239 | 0.083 |
12 | 0.261 | 0.245 | 0.212 | 0.282 |
A | C | G | T | |
---|---|---|---|---|
01 | -0.05 | -0.233 | 0.17 | 0.069 |
02 | -0.409 | 0.533 | -0.222 | -0.186 |
03 | 0.117 | -0.057 | 0.516 | -1.36 |
04 | -1.651 | 0.515 | -0.675 | 0.486 |
05 | -4.506 | -5.972 | -6.619 | 1.383 |
06 | 1.386 | -6.98 | -6.98 | -6.98 |
07 | 1.386 | -6.98 | -6.98 | -6.98 |
08 | -6.98 | -6.98 | 0.184 | 1.028 |
09 | -5.021 | -4.044 | 0.638 | 0.734 |
10 | -0.395 | -0.937 | 1.047 | -2.464 |
11 | 0.281 | 0.328 | -0.047 | -1.097 |
12 | 0.043 | -0.019 | -0.166 | 0.12 |
P-value | Threshold |
---|---|
0.001 | 5.33011 |
0.0005 | 6.187575 |
0.0001 | 7.53685 |