MotifISL1.H12CORE.0.PSM.A
Gene (human)ISL1
(GeneCards)
Gene synonyms (human)
Gene (mouse)Isl1
Gene synonyms (mouse)
LOGO
LOGO (reverse complement)
Motif subtype0
Quality
A
Motif length12
ConsensusnbvbTAATKRvn
GC content41.28%
Information content (bits; total / per base)9.668 / 0.806
Data sourcesChIP-Seq + HT-SELEX + Methyl-HT-SELEX
Aligned words9875

ChIP-Seq benchmarking Num. of experiments (peaksets) auROC, median auROC, best auPRC, median auPRC, best pseudo-auROC, median pseudo-auROC, best pseudo-log-auROC, median pseudo-log-auROC, best Centrality, median Centrality, best
Human 2 (14) 0.705 0.808 0.6 0.663 0.615 0.735 1.497 1.88 47.531 85.678
Mouse 4 (16) 0.833 0.854 0.726 0.763 0.745 0.767 1.994 2.122 101.968 131.509

HT-SELEX benchmarking auROC10 auPRC10 auROC25 auPRC25 auROC50 auPRC50
Overall, 4 experiments median 0.96 0.935 0.936 0.904 0.883 0.849
best 0.976 0.961 0.959 0.937 0.917 0.892
Methyl HT-SELEX, 2 experiments median 0.967 0.947 0.944 0.917 0.89 0.862
best 0.976 0.961 0.959 0.937 0.917 0.892
Non-Methyl HT-SELEX, 2 experiments median 0.958 0.932 0.934 0.901 0.883 0.849
best 0.962 0.938 0.942 0.911 0.899 0.866

rSNP benchmarking, SNP-SELEX auROC auPRC Pearson r Kendall tau
batch 2 0.64 0.185 0.351 0.187
TF superclassHelix-turn-helix domains {3} (TFClass)
TF classHomeo domain factors {3.1} (TFClass)
TF familyHD-LIM {3.1.5} (TFClass)
TF subfamilyISL {3.1.5.1} (TFClass)
TFClass IDTFClass: 3.1.5.1.1
HGNCHGNC:6132
MGIMGI:101791
EntrezGene (human)GeneID:3670
(SSTAR profile)
EntrezGene (mouse)GeneID:16392
(SSTAR profile)
UniProt ID (human)ISL1_HUMAN
UniProt ID (mouse)ISL1_MOUSE
UniProt AC (human)P61371
(TFClass)
UniProt AC (mouse)P61372
(TFClass)
GRECO-DB-TF
yes
ChIP-Seq 2 human, 4 mouse
HT-SELEX 2
Methyl-HT-SELEX 2
PCM
ACGT
012348.251954.252926.252646.25
021639.54210.51976.52048.5
032776.02331.04136.0632.0
04472.04132.01256.04015.0
0525.04.01.09845.0
069875.00.00.00.0
079875.00.00.00.0
080.00.02968.06907.0
0914.041.04674.05146.0
101662.0966.07039.0208.0
113269.03427.02356.0823.0
122577.752422.752091.752782.75
PFM
ACGT
010.2380.1980.2960.268
020.1660.4260.20.207
030.2810.2360.4190.064
040.0480.4180.1270.407
050.0030.00.00.997
061.00.00.00.0
071.00.00.00.0
080.00.00.3010.699
090.0010.0040.4730.521
100.1680.0980.7130.021
110.3310.3470.2390.083
120.2610.2450.2120.282
PWM
ACGT
01-0.05-0.2330.170.069
02-0.4090.533-0.222-0.186
030.117-0.0570.516-1.36
04-1.6510.515-0.6750.486
05-4.506-5.972-6.6191.383
061.386-6.98-6.98-6.98
071.386-6.98-6.98-6.98
08-6.98-6.980.1841.028
09-5.021-4.0440.6380.734
10-0.395-0.9371.047-2.464
110.2810.328-0.047-1.097
120.043-0.019-0.1660.12
Standard thresholds
P-value Threshold
0.001 5.33011
0.0005 6.187575
0.0001 7.53685