MotifIRX5.H12INVITRO.0.M.C
Gene (human)IRX5
(GeneCards)
Gene synonyms (human)IRX2A, IRXB2
Gene (mouse)Irx5
Gene synonyms (mouse)Irxb2
LOGO
LOGO (reverse complement)
Motif subtype0
Quality
C
Motif length11
ConsensusnRCGCGTWAvn
GC content51.47%
Information content (bits; total / per base)10.69 / 0.972
Data sourcesMethyl-HT-SELEX
Aligned words1393

HT-SELEX benchmarking auROC10 auPRC10 auROC25 auPRC25 auROC50 auPRC50
Overall, 6 experiments median 0.879 0.807 0.868 0.798 0.84 0.775
best 0.928 0.886 0.902 0.854 0.87 0.82
Methyl HT-SELEX, 2 experiments median 0.925 0.884 0.897 0.848 0.859 0.809
best 0.928 0.886 0.902 0.854 0.87 0.82
Non-Methyl HT-SELEX, 4 experiments median 0.829 0.75 0.803 0.732 0.757 0.701
best 0.888 0.82 0.88 0.812 0.851 0.787
TF superclassHelix-turn-helix domains {3} (TFClass)
TF classHomeo domain factors {3.1} (TFClass)
TF familyTALE-type HD {3.1.4} (TFClass)
TF subfamilyIRX {3.1.4.1} (TFClass)
TFClass IDTFClass: 3.1.4.1.5
HGNCHGNC:14361
MGIMGI:1859086
EntrezGene (human)GeneID:10265
(SSTAR profile)
EntrezGene (mouse)GeneID:54352
(SSTAR profile)
UniProt ID (human)IRX5_HUMAN
UniProt ID (mouse)IRX5_MOUSE
UniProt AC (human)P78411
(TFClass)
UniProt AC (mouse)Q9JKQ4
(TFClass)
GRECO-DB-TF
yes
ChIP-Seq 0 human, 0 mouse
HT-SELEX 4
Methyl-HT-SELEX 2
PCM
ACGT
01393.5359.5254.5385.5
02844.2566.25250.25232.25
030.01332.00.061.0
04433.00.0942.018.0
050.01107.00.0286.0
060.00.01393.00.0
070.00.00.01393.0
08725.040.00.0628.0
09999.0363.031.00.0
10327.75691.75265.75107.75
11359.5339.5451.5242.5
PFM
ACGT
010.2820.2580.1830.277
020.6060.0480.180.167
030.00.9560.00.044
040.3110.00.6760.013
050.00.7950.00.205
060.00.01.00.0
070.00.00.01.0
080.520.0290.00.451
090.7170.2610.0220.0
100.2350.4970.1910.077
110.2580.2440.3240.174
PWM
ACGT
010.1220.032-0.3120.101
020.882-1.638-0.328-0.403
03-5.2651.338-5.265-1.718
040.217-5.2650.992-2.872
05-5.2651.153-5.265-0.196
06-5.265-5.2651.382-5.265
07-5.265-5.265-5.2651.382
080.731-2.125-5.2650.587
091.050.041-2.367-5.265
10-0.060.684-0.269-1.162
110.032-0.0250.258-0.36
Standard thresholds
P-value Threshold
0.001 4.638945
0.0005 5.859315
0.0001 7.671225