IRF8.H12INVIVO.0.P.B motif - HOmo sapiens COmprehensive MOdel COllection

Motif	IRF8.H12INVIVO.0.P.B
Gene (human)	IRF8 (GeneCards)
Gene synonyms (human)	ICSBP1
Gene (mouse)	Irf8
Gene synonyms (mouse)	Icsbp, Icsbp1
LOGO
LOGO (reverse complement)
Motif subtype	0
Quality	B

Motif length	19
Consensus	vdWWRRGGAASTGARMvhn
GC content	45.21%
Information content (bits; total / per base)	15.905 / 0.837
Data sources	ChIP-Seq
Aligned words	1010

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Mouse	27 (157)	0.945	0.983	0.898	0.97	0.962	0.988	5.048	6.671	353.638	919.292

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 7 experiments	median	0.87	0.833	0.738	0.721	0.638	0.641
Overall, 7 experiments	best	0.983	0.971	0.953	0.935	0.9	0.873
Methyl HT-SELEX, 2 experiments	median	0.801	0.776	0.757	0.738	0.686	0.679
Methyl HT-SELEX, 2 experiments	best	0.973	0.953	0.939	0.915	0.833	0.821
Non-Methyl HT-SELEX, 5 experiments	median	0.87	0.833	0.738	0.721	0.638	0.641
Non-Methyl HT-SELEX, 5 experiments	best	0.983	0.971	0.953	0.935	0.9	0.873

rSNP benchmarking, SNP-SELEX	auROC	auPRC	Pearson r	Kendall tau
batch 1	0.792	0.231	0.475	0.297
batch 2	0.656	0.328	0.45	0.337

TF superclass	Helix-turn-helix domains {3} (TFClass)
TF class	Tryptophan cluster factors {3.5} (TFClass)
TF family	IRF {3.5.3} (TFClass)
TF subfamily	{3.5.3.0} (TFClass)
TFClass ID	TFClass: 3.5.3.0.8
HGNC	HGNC:5358
MGI	MGI:96395
EntrezGene (human)	GeneID:3394 (SSTAR profile)
EntrezGene (mouse)	GeneID:15900 (SSTAR profile)
UniProt ID (human)	IRF8_HUMAN
UniProt ID (mouse)	IRF8_MOUSE
UniProt AC (human)	Q02556 (TFClass)
UniProt AC (mouse)	P23611 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	0 human, 27 mouse
HT-SELEX	5
Methyl-HT-SELEX	2

PCM	IRF8.H12INVIVO.0.P.B.pcm
PWM	IRF8.H12INVIVO.0.P.B.pwm
PFM	IRF8.H12INVIVO.0.P.B.pfm
Alignment	IRF8.H12INVIVO.0.P.B.words.tsv
Threshold to P-value map	IRF8.H12INVIVO.0.P.B.thr
Motif in other formats
JASPAR format	IRF8.H12INVIVO.0.P.B_jaspar_format.txt
MEME format	IRF8.H12INVIVO.0.P.B_meme_format.meme
Transfac format	IRF8.H12INVIVO.0.P.B_transfac_format.txt
Homer format	IRF8.H12INVIVO.0.P.B_homer_format_0.001.txt IRF8.H12INVIVO.0.P.B_homer_format_0.0005.txt IRF8.H12INVIVO.0.P.B_homer_format_0.0001.txt

PCM

	A	C	G	T
01	373.0	171.0	338.0	128.0
02	547.0	94.0	206.0	163.0
03	647.0	76.0	130.0	157.0
04	593.0	25.0	156.0	236.0
05	228.0	124.0	625.0	33.0
06	539.0	111.0	333.0	27.0
07	170.0	0.0	838.0	2.0
08	50.0	1.0	959.0	0.0
09	1003.0	3.0	2.0	2.0
10	993.0	2.0	5.0	10.0
11	77.0	289.0	638.0	6.0
12	69.0	64.0	14.0	863.0
13	14.0	1.0	993.0	2.0
14	782.0	8.0	186.0	34.0
15	546.0	53.0	352.0	59.0
16	738.0	135.0	84.0	53.0
17	171.0	412.0	366.0	61.0
18	170.0	329.0	123.0	388.0
19	327.0	165.0	265.0	253.0

PFM

	A	C	G	T
01	0.369	0.169	0.335	0.127
02	0.542	0.093	0.204	0.161
03	0.641	0.075	0.129	0.155
04	0.587	0.025	0.154	0.234
05	0.226	0.123	0.619	0.033
06	0.534	0.11	0.33	0.027
07	0.168	0.0	0.83	0.002
08	0.05	0.001	0.95	0.0
09	0.993	0.003	0.002	0.002
10	0.983	0.002	0.005	0.01
11	0.076	0.286	0.632	0.006
12	0.068	0.063	0.014	0.854
13	0.014	0.001	0.983	0.002
14	0.774	0.008	0.184	0.034
15	0.541	0.052	0.349	0.058
16	0.731	0.134	0.083	0.052
17	0.169	0.408	0.362	0.06
18	0.168	0.326	0.122	0.384
19	0.324	0.163	0.262	0.25

PWM

	A	C	G	T
01	0.388	-0.387	0.29	-0.673
02	0.769	-0.977	-0.202	-0.434
03	0.937	-1.185	-0.657	-0.471
04	0.85	-2.252	-0.477	-0.067
05	-0.101	-0.704	0.902	-1.991
06	0.755	-0.813	0.275	-2.18
07	-0.392	-4.99	1.195	-4.222
08	-1.592	-4.534	1.329	-4.99
09	1.374	-3.984	-4.222	-4.222
10	1.364	-4.222	-3.632	-3.076
11	-1.172	0.134	0.923	-3.493
12	-1.279	-1.353	-2.783	1.224
13	-2.783	-4.534	1.364	-4.222
14	1.126	-3.263	-0.303	-1.962
15	0.768	-1.536	0.33	-1.432
16	1.068	-0.62	-1.087	-1.536
17	-0.387	0.487	0.369	-1.399
18	-0.392	0.263	-0.712	0.427
19	0.257	-0.422	0.048	0.002

Standard thresholds

P-value	Threshold
0.001	2.43016
0.0005	3.70361
0.0001	6.34261