IRF8.H12INVITRO.1.SM.B motif - HOmo sapiens COmprehensive MOdel COllection

Motif	IRF8.H12INVITRO.1.SM.B
Gene (human)	IRF8 (GeneCards)
Gene synonyms (human)	ICSBP1
Gene (mouse)	Irf8
Gene synonyms (mouse)	Icsbp, Icsbp1
LOGO
LOGO (reverse complement)
Motif subtype	1
Quality	B

Motif length	15
Consensus	bRRWASCGAAACYdn
GC content	46.24%
Information content (bits; total / per base)	16.986 / 1.132
Data sources	HT-SELEX + Methyl-HT-SELEX
Aligned words	1346

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Mouse	27 (157)	0.835	0.956	0.747	0.915	0.828	0.942	2.787	3.882	238.745	844.796

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 7 experiments	median	0.991	0.989	0.943	0.927	0.843	0.833
Overall, 7 experiments	best	1.0	1.0	0.999	0.999	0.992	0.99
Methyl HT-SELEX, 2 experiments	median	0.945	0.932	0.88	0.871	0.802	0.803
Methyl HT-SELEX, 2 experiments	best	0.999	0.999	0.995	0.994	0.951	0.947
Non-Methyl HT-SELEX, 5 experiments	median	0.991	0.989	0.943	0.927	0.843	0.833
Non-Methyl HT-SELEX, 5 experiments	best	1.0	1.0	0.999	0.999	0.992	0.99

rSNP benchmarking, SNP-SELEX	auROC	auPRC	Pearson r	Kendall tau
batch 1	0.933	0.735	0.905	0.556
batch 2	0.859	0.691	0.841	0.632

TF superclass	Helix-turn-helix domains {3} (TFClass)
TF class	Tryptophan cluster factors {3.5} (TFClass)
TF family	IRF {3.5.3} (TFClass)
TF subfamily	{3.5.3.0} (TFClass)
TFClass ID	TFClass: 3.5.3.0.8
HGNC	HGNC:5358
MGI	MGI:96395
EntrezGene (human)	GeneID:3394 (SSTAR profile)
EntrezGene (mouse)	GeneID:15900 (SSTAR profile)
UniProt ID (human)	IRF8_HUMAN
UniProt ID (mouse)	IRF8_MOUSE
UniProt AC (human)	Q02556 (TFClass)
UniProt AC (mouse)	P23611 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	0 human, 27 mouse
HT-SELEX	5
Methyl-HT-SELEX	2

PCM	IRF8.H12INVITRO.1.SM.B.pcm
PWM	IRF8.H12INVITRO.1.SM.B.pwm
PFM	IRF8.H12INVITRO.1.SM.B.pfm
Alignment	IRF8.H12INVITRO.1.SM.B.words.tsv
Threshold to P-value map	IRF8.H12INVITRO.1.SM.B.thr
Motif in other formats
JASPAR format	IRF8.H12INVITRO.1.SM.B_jaspar_format.txt
MEME format	IRF8.H12INVITRO.1.SM.B_meme_format.meme
Transfac format	IRF8.H12INVITRO.1.SM.B_transfac_format.txt
Homer format	IRF8.H12INVITRO.1.SM.B_homer_format_0.001.txt IRF8.H12INVITRO.1.SM.B_homer_format_0.0005.txt IRF8.H12INVITRO.1.SM.B_homer_format_0.0001.txt

PCM

	A	C	G	T
01	138.25	789.25	148.25	270.25
02	131.5	97.5	1067.5	49.5
03	1055.0	93.0	144.0	54.0
04	1001.0	47.0	42.0	256.0
05	1322.0	5.0	3.0	16.0
06	32.0	963.0	207.0	144.0
07	1.0	1177.0	1.0	167.0
08	2.0	0.0	1344.0	0.0
09	1345.0	0.0	0.0	1.0
10	1303.0	0.0	0.0	43.0
11	1345.0	1.0	0.0	0.0
12	8.0	1135.0	200.0	3.0
13	83.0	520.0	62.0	681.0
14	474.5	181.5	476.5	213.5
15	409.25	358.25	273.25	305.25

PFM

	A	C	G	T
01	0.103	0.586	0.11	0.201
02	0.098	0.072	0.793	0.037
03	0.784	0.069	0.107	0.04
04	0.744	0.035	0.031	0.19
05	0.982	0.004	0.002	0.012
06	0.024	0.715	0.154	0.107
07	0.001	0.874	0.001	0.124
08	0.001	0.0	0.999	0.0
09	0.999	0.0	0.0	0.001
10	0.968	0.0	0.0	0.032
11	0.999	0.001	0.0	0.0
12	0.006	0.843	0.149	0.002
13	0.062	0.386	0.046	0.506
14	0.353	0.135	0.354	0.159
15	0.304	0.266	0.203	0.227

PWM

	A	C	G	T
01	-0.882	0.849	-0.813	-0.218
02	-0.931	-1.226	1.151	-1.886
03	1.139	-1.272	-0.842	-1.802
04	1.087	-1.936	-2.044	-0.272
05	1.364	-3.907	-4.255	-2.945
06	-2.303	1.048	-0.483	-0.842
07	-4.794	1.248	-4.794	-0.695
08	-4.489	-5.235	1.381	-5.235
09	1.382	-5.235	-5.235	-4.794
10	1.35	-5.235	-5.235	-2.022
11	1.382	-4.794	-5.235	-5.235
12	-3.541	1.212	-0.517	-4.255
13	-1.384	0.433	-1.668	0.702
14	0.342	-0.613	0.346	-0.452
15	0.195	0.062	-0.207	-0.097

Standard thresholds

P-value	Threshold
0.001	1.09581
0.0005	2.58906
0.0001	5.70366