IRF8.H12CORE.2.SM.B motif - HOmo sapiens COmprehensive MOdel COllection

Motif	IRF8.H12CORE.2.SM.B
Gene (human)	IRF8 (GeneCards)
Gene synonyms (human)	ICSBP1
Gene (mouse)	Irf8
Gene synonyms (mouse)	Icsbp, Icsbp1
LOGO
LOGO (reverse complement)
Motif subtype	2
Quality	B

Motif length	14
Consensus	vvWAbCGAAACYvn
GC content	42.6%
Information content (bits; total / per base)	13.383 / 0.956
Data sources	HT-SELEX + Methyl-HT-SELEX
Aligned words	9920

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Mouse	27 (157)	0.845	0.958	0.75	0.915	0.833	0.948	2.805	4.081	245.252	899.699

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 7 experiments	median	0.994	0.992	0.953	0.937	0.854	0.845
Overall, 7 experiments	best	1.0	0.999	0.999	0.998	0.994	0.992
Methyl HT-SELEX, 2 experiments	median	0.95	0.936	0.882	0.874	0.804	0.807
Methyl HT-SELEX, 2 experiments	best	0.999	0.999	0.994	0.993	0.957	0.953
Non-Methyl HT-SELEX, 5 experiments	median	0.994	0.992	0.953	0.937	0.854	0.845
Non-Methyl HT-SELEX, 5 experiments	best	1.0	0.999	0.999	0.998	0.994	0.992

rSNP benchmarking, SNP-SELEX	auROC	auPRC	Pearson r	Kendall tau
batch 1	0.926	0.725	0.883	0.549
batch 2	0.864	0.709	0.841	0.634

TF superclass	Helix-turn-helix domains {3} (TFClass)
TF class	Tryptophan cluster factors {3.5} (TFClass)
TF family	IRF {3.5.3} (TFClass)
TF subfamily	{3.5.3.0} (TFClass)
TFClass ID	TFClass: 3.5.3.0.8
HGNC	HGNC:5358
MGI	MGI:96395
EntrezGene (human)	GeneID:3394 (SSTAR profile)
EntrezGene (mouse)	GeneID:15900 (SSTAR profile)
UniProt ID (human)	IRF8_HUMAN
UniProt ID (mouse)	IRF8_MOUSE
UniProt AC (human)	Q02556 (TFClass)
UniProt AC (mouse)	P23611 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	0 human, 27 mouse
HT-SELEX	5
Methyl-HT-SELEX	2

PCM	IRF8.H12CORE.2.SM.B.pcm
PWM	IRF8.H12CORE.2.SM.B.pwm
PFM	IRF8.H12CORE.2.SM.B.pfm
Alignment	IRF8.H12CORE.2.SM.B.words.tsv
Threshold to P-value map	IRF8.H12CORE.2.SM.B.thr
Motif in other formats
JASPAR format	IRF8.H12CORE.2.SM.B_jaspar_format.txt
MEME format	IRF8.H12CORE.2.SM.B_meme_format.meme
Transfac format	IRF8.H12CORE.2.SM.B_transfac_format.txt
Homer format	IRF8.H12CORE.2.SM.B_homer_format_0.001.txt IRF8.H12CORE.2.SM.B_homer_format_0.0005.txt IRF8.H12CORE.2.SM.B_homer_format_0.0001.txt

PCM

	A	C	G	T
01	1968.5	1522.5	5380.5	1048.5
02	5762.0	1143.0	2137.0	878.0
03	6678.0	785.0	1075.0	1382.0
04	8443.0	419.0	216.0	842.0
05	1454.0	4509.0	1910.0	2047.0
06	141.0	7877.0	69.0	1833.0
07	82.0	32.0	9774.0	32.0
08	9779.0	55.0	34.0	52.0
09	9621.0	31.0	35.0	233.0
10	9768.0	41.0	30.0	81.0
11	109.0	8347.0	1370.0	94.0
12	550.0	3150.0	171.0	6049.0
13	4219.0	1219.0	3267.0	1215.0
14	3716.0	2417.0	2145.0	1642.0

PFM

	A	C	G	T
01	0.198	0.153	0.542	0.106
02	0.581	0.115	0.215	0.089
03	0.673	0.079	0.108	0.139
04	0.851	0.042	0.022	0.085
05	0.147	0.455	0.193	0.206
06	0.014	0.794	0.007	0.185
07	0.008	0.003	0.985	0.003
08	0.986	0.006	0.003	0.005
09	0.97	0.003	0.004	0.023
10	0.985	0.004	0.003	0.008
11	0.011	0.841	0.138	0.009
12	0.055	0.318	0.017	0.61
13	0.425	0.123	0.329	0.122
14	0.375	0.244	0.216	0.166

PWM

	A	C	G	T
01	-0.231	-0.487	0.774	-0.86
02	0.842	-0.774	-0.149	-1.037
03	0.99	-1.148	-0.835	-0.584
04	1.224	-1.774	-2.431	-1.078
05	-0.533	0.597	-0.261	-0.192
06	-2.852	1.155	-3.55	-0.302
07	-3.383	-4.282	1.371	-4.282
08	1.371	-3.769	-4.225	-3.822
09	1.355	-4.311	-4.198	-2.356
10	1.37	-4.049	-4.342	-3.394
11	-3.105	1.213	-0.593	-3.249
12	-1.503	0.239	-2.662	0.891
13	0.531	-0.709	0.275	-0.713
14	0.404	-0.026	-0.145	-0.412

Standard thresholds

P-value	Threshold
0.001	3.37256
0.0005	4.54771
0.0001	6.97611